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Interactive Pathways & Processes

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Platelet GP Adhesion Protein Signaling

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Granule
Release

DEP-1/CD148

CLEC-2

Src

GPIb-IX-V

Src

Lyn

FCER1G

Syk

Complex
Formation

LAT

BTK

PLC-gamma

Vav-1

SLP-76

IP₃

DAG

Calcium Release

PKC alpha
PKC beta

CalDAG-GEFI

RIAM

Rap1

Integrin
Activation

Lyn

Fyn

PI 3-Kinase

FCER1G

Syk

GPVI

Lyn

Fyn

DEP-1/CD148

Complex
Formation

Rap1B

Integrin
Activation

MAPK

PLA2G4A

Thromboxane Synthase

Thromboxane A2
Production

Akt

eNOS

Soluble
Guanylyl
Cyclase

cGMP

PKG

MAPK

ERK1/2

Granule
Release

Overview of Platelet Signaling Through GP Adhesion Proteins

The GP family of glycoproteins mediate the initial adhesion of platelets to the endothelium. They interact with several ECM molecules at sites of endothelial damage and also with circulating soluble factors. GP adhesion proteins associate in cis with other platelet surface molecules and initiate intracellular signaling that leads to the activation of Src family kinases, PLC gamma, PKC, PI-3 Kinase, and eNOS. GP signaling induces platelet granule release, integrin activation, and production of thromboxane A2.

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