R&D Systems supports inflammation research with a full line of recombinant proteins and antibodies as well as Tocris Bioscience peptides and small molecules. Our immunoassay selection includes Quantikine® and DuoSet® ELISA kits, ELISpot kits, Luminex® assays, and Proteome Profiler™ antibody arrays. We also provide stem cell and cell culture products to support your research. Learn More.
 |
 |
 |
 |
Recombinant Proteins
Quantikine® and DuoSet® ELISA Kits
Small Molecule Agonists and Antagonists
Inflammation Literature and Resources
Brochures and Product Guides
Cardiovascular Research Product Guide
CD4+ T Cell Subset Characterization
Products for Chemokine Research
Products for IL-1 Family Research
Signal Transduction Antibody Reference Guide
Posters
Atherosclerosis Disease Progression
References and Troubleshooting Guides
Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
Inflammasome Activation Pathways
Protocols/Troubleshooting Guides From Novus Biologicals®
Protocols/Troubleshooting Guides From R&D Systems®
Background
Inflammation is a protective immune mechanism that is triggered by infection or tissue damage. The early phase of inflammation is characterized by the infiltration and activation of macrophages and dendritic cells. These cells release inflammatory mediators which attract additional leukocytes (e.g. neutrophils, eosinophils, and mast cells) to the site of infection or damage. Inflammatory mediators include chemokines, cytokines, proteases and oxidative enzymes, eicosanoids and leukotrienes, and anti-microbial peptides. Inflammatory reactions are critical for clearing microbial infections and initiating tissue repair. Abnormal resolution of these reactions leads to chronic inflammation which is a prominent feature of many diseases including cancer, diabetes, atherosclerosis, arthritis, and inflammatory bowel disease.