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Our reagents for cancer stem cell research are organized below by workflow: Isolate and Culture, Verification, Differentiation, and Investigation. Click on the navigation arrows to quickly jump to the different steps of the workflow.
MagCellect™ CD24-CD44+ Breast Cancer Stem Cell Isolation Kit
Isolates CD24-CD44+ breast cancer stem cells via negative and positive selection.
Cultrex 3D Spheroid Cell Invasion Assay
To assess tumor cell invasion in response to user-defined chemoattractants or invasion-modulating compounds.
StemXVivo™ Serum-Free Tumorsphere Media
Specialized semi-solid media optimized for tumorsphere formation.
CryoDefend™-Stem Cells Media
Media for defined, protein-free cryopreservation of stem cells.
Growth Factors
Premium quality proteins that support cancer stem cell proliferation in culture.
Antibodies to Detect Cancer Stem Cell Markers
Analyzes the expression of identified cancer stem cell markers in specific malignancies.
Small Molecules to Investigate CSCs
View a listing of Tocris brand pharmacological reagents for cancer stem cell research.
Cancer Stem Cell Transcription Factors
To study the expression of genes that control abnormal self-renewal, proliferation, and differentiation of neoplastic cells.
Epithelial to Mesenchymal Transition Products
Tools to induce and evaluate epithelial to mesenchymal transition, the biological process implicated in cancer stem cell generation and metastasis.
Cultrex 3D Spheroid Cell Invasion Assay
To assess tumor cell invasion in response to user-defined chemoattractants or invasion-modulating compounds.
What are Cancer Stem Cells?
The cancer stem cell hypothesis states that a subset of self-renewing cells drive tumorigenesis. If this is the case, it suggests that targeted elimination of the stem cell-like population of cancer cells is a viable therapeutic strategy for several malignancies. However, an overriding experimental limitation for cancer stem cell researchers is the ability to identify and isolate cancer stem cells from other tumor cells. To address this need, R&D Systems offers a broad selection of tools to facilitate the identification and isolation of specific cancer stem cell populations. Classical developmental signaling pathways, which are implicated in oncogenesis, are also associated with regulation of stem cell self-renewal and provide additional areas of focus for understanding cancer stem cell biology.