Home / Retinoic Acid Receptor Agonists / AC 261066

AC 261066

Catalog #: 4046
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4046/10
4046/50
AC 261066 | CAS No. 870773-76-5 | Retinoic Acid Receptor Agonists
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Description: RARβ2 agonist

Chemical Name: 4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AC 261066 is a potent RARβ2 agonist (pEC50 = 8.1). Selective over RARβ1, RARα and RARγ (pEC50 values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649 (Cat. No. 2436).

Technical Data

M.Wt:
353.41
Formula:
C17H20FNO4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
870773-76-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease
    M Melis, XH Tang, SE Trasino, VM Patel, DJ Stummer, J Jessurun, LJ Gudas
    PLoS ONE, 2019;14(1):e0211071.
  2. Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity.
    Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L
    Biochem Biophys Res Commun, 2014;454(4):537-542.
  3. Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist.
    Lund et al.
    J.Med.Chem., 2005;48:7517
  4. Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands.
    Lund et al.
    J.Med.Chem., 2009;52:1540

Product Datasheets

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Reconstitution Calculator

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Citation for AC 261066

The citations listed below are publications that use Tocris products. Selected citations for AC 261066 include:

1 Citation: Showing 1 - 1

  1. A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes.
    Authors: Lorraine J Et al.
    Biofactors  2022;48:469-480

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