BGC 20-761
Chemical Name: 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
Purity: ≥98%
Biological Activity
BGC 20-761 is a selective, high affinity 5-HT6 antagonist (Ki = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors.
Glennon et al.
J.Med.Chem., 2000;43:1011 -
BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism.
Mitchell et al.
Neuropharmacology, 2006;50:412
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