Capecitabine
Discontinued Product
Chemical Name: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
Purity: ≥98%
Biological Activity
Capecitabine is a prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
Shimma et al.
Bioorg.Med.Chem.Lett., 2000;8:1697 -
Cell cycle phase specificity of antitumor agents.
Bhuyan et al.
Cancer Res., 1972;32:398 -
Metabolism of capecitabine, an oral fluorou. prodrug: 19F NMR studies in animal models and human urine.
Desmoulin et al.
Drug Metab.Dispos., 2002;30:1221
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