Cynomolgus Monkey Siglec-2/CD22 (EHH59463) VersaClone cDNA

Cynomolgus Monkey Siglec-2/CD22 (EHH59463) VersaClone cDNA Summary

Specifications

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Background: Siglec-2/CD22

Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.

Related Research Areas

• Acute Lymphoblastic Leukemia
• B Cell Activation
• B Cell Markers
• Dendritic Cell Activation
• Dendritic Cell Adhesion and Migration
• Dendritic Cell ITIM/ITAM Immunoreceptors
• Ig-type Lectins
• ITIM/ITAM Immunoreceptors and Related Molecules
• Lymphoid Lineage Markers
• Lymphoma
• Microglia Homeostasis