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CZC 24832

Catalog #: 4674 Datasheet / COA / SDS

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4674 has been discontinued.
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CZC 24832 | CAS No. 1159824-67-5 | PI 3-Kinase Inhibitors
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Description: Selective inhibitor of PI 3-kinase γ

Chemical Name: 5-(2-Amino-8-fluoro[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(1,1-dimethylethyl)-3-pyridinesulfonamide

Purity: ≥98%

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Biological Activity

CZC 24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease.

Technical Data

M.Wt:
364.4
Formula:
C15H17FN6O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1159824-67-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.
    Bergamini et al.
    Nat.Chem.Biol., 2012;8:576

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