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Dooku 1

Catalog #: 6568
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6568/50
6568/10
Dooku 1 | CAS No. 2253744-54-4 | Other Piezo Channel Compounds
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Description: Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity

Chemical Name: 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Dooku 1 reversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ~1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonizes Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.

Technical Data

M.Wt:
326.2
Formula:
C13H9Cl2N3OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2253744-54-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Dooku 1

The citations listed below are publications that use Tocris products. Selected citations for Dooku 1 include:

1 Citation: Showing 1 - 1

  1. Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone.
    Authors: Yan Et al.
    Cell Biosci  2022;12:191

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