Fendiline Hydrochloride
Chemical Name: N-(3,3-Diphenylpropyl)-α-methylbenzylamine hydrochloride
Purity: ≥98%
Biological Activity
Fendiline Hydrochloride is a K-Ras inhibitor. Selectively inhibits K-Ras localization to the plasma membrane (IC50 = 9.64 μM). Blocks proliferation of cancer cell lines expressing oncogenic mutant K-Ras. Also inhibits L-type calcium channels (IC50 = 17 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: a whole-cell patch-clamp study.
Tripathi et al.
Br.J.Pharmacol., 1993;108:865 -
Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.
van der Hoeven et al.
Mol.Cell.Biol., 2015;33:237 -
Novel Antrodia cinnamomea Extract Reduced Cancer Stem-Like Phenotype Changes and Resensitized KRAS-Mutant Colorectal Cancer via a MicroRNA-27a Pathway
TJ Lin, KC Lai, AS Lee, CH Chang, CL Liu, CH Chung
Cancers (Basel), 2019;11(11):.
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Citation for Fendiline Hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Fendiline Hydrochloride include:
1 Citation: Showing 1 - 1
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Global feather orientations changed by electric current.
Authors: Ting-Xin Et al.
iScience 2021;24:102671
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