Human ADAM9 Ectodomain Antibody Summary
Accession # Q13443
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ADAM9
ADAM9, also known as MDC9 or meltrin gamma, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain (1). Like other membrane-anchored ADAMs, ADAM9 consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Met-turn expected for reprolysins, a disintegrin-like domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. ADAM9 is able to cleave peptides corresponding to cleavage sites of tumor necrosis factor-alpha (TNF-alpha ), the p75 TNF receptor, the beta -amyloid protein precursor, and the c-kit ligand-1, implying that it may participate in shedding of these membrane proteins (2). In fact, ADAM9 has been shown to shed membrane-anchored heparin-binding EGF-like growth factor (3). In addition, it also cleaves oxidized insulin beta -chain and fibronectin (2,4). Besides its catalytic activity, ADAM9 functions as an adhesion molecule through binding of its disintegrin domain to integrins such as alpha v beta 5 and alpha 6 beta 1 (5, 6). The cytoplasmic domain of ADAM9 interacts with Src homology 3
(SH3)‑containing proteins and protein kinase C, and may mediate different signaling pathways (3, 7). ADAM9 is widely expressed in tissues (8).
- Moss, et al. (2001) DDT 6:417.
- Roghan, et al. (1999) J. Biol. Chem. 274:3531.
- Izumi, et al. (1998) EMBO J. 17:7260.
- Schwettmann and Tschesche (2001) Prot. Expre. & Purif. 21:65.
- Nath, et al. (2000) J. Cell Sci. 113:2319.
- Zhou, et al. (2001) Biochem. Biophys. Res. Comm. 280:574.
- Howard, et al. (1999) J. Biol. Chem. 274:31693.
- Weskamp, et al. (1996) J. Cell. Biol. 132:717.
Product Datasheets
Citations for Human ADAM9 Ectodomain Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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ADAM9 expression promotes an aggressive lung adenocarcinoma phenotype
Authors: Céline Mongaret Kossmann, Maxime Annereau, Audrey Thomas-Schoemann, Carole Nicco-Overney, Christiane Chéreau, Frédéric Batteux et al.
Tumour Biol
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ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death
Authors: M Ueno, T Shiomi, S Mochizuki, M Chijiiwa, M Shimoda, Y Kanai, F Kataoka, A Hirasawa, N Susumu, D Aoki, Y Okada
Cancer Sci., 2018-02-01;109(2):471-482.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT
Authors: CY Lin, CF Cho, ST Bai, JP Liu, TT Kuo, LJ Wang, YS Lin, CC Lin, LC Lai, TP Lu, CY Hsieh, CN Chu, DC Cheng, YP Sher
Sci Rep, 2017-11-08;7(1):15108.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway.
Authors: Lin C, Chen H, Huang C, Lai L, Lu T, Tseng G, Kuo T, Kuok Q, Hsu J, Sung S, Hung M, Sher Y
Cancer Res, 2014-07-24;74(18):5229-43.
Species: Human, Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Oxidative stress induces ADAM9 protein expression in human prostate cancer cells.
Authors: Sung SY, Kubo H, Shigemura K, Arnold RS, Logani S, Wang R, Konaka H, Nakagawa M, Mousses S, Amin M, Anderson C, Johnstone P, Petros JA, Marshall FF, Zhau HE, Chung LW
Cancer Res., 2006-10-01;66(19):9519-26.
Species: Human
Sample Types: Cell Lysates, Whole Tissue
Applications: IHC-P, Western Blot -
ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin.
Authors: Karadag A, Zhou M, Croucher PI
Blood, 2005-12-22;107(8):3271-8.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis
Authors: Kuo-Liang Chiu, Ting-Ting Kuo, Qian-Yu Kuok, Yu-Sen Lin, Chung-Hung Hua, Chen-Yuan Lin et al.
Scientific Reports
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