Human Apolipoprotein A-I Quantikine ELISA Kit Summary
Product Summary
Recovery
The recovery of human ApoA1 spiked to levels throughout the range of the assay in various matrices was evaluated.
| Sample Type | Average % Recovery | Range % |
|---|---|---|
| Cell Culture Media (n=4) | 97 | 90-114 |
| Urine (n=4) | 99 | 83-109 |
Linearity
Scientific Data
Product Datasheets
Preparation and Storage
Background: Apolipoprotein A-I/ApoA1
The apolipoproteins are a structurally-unrelated group of proteins that have some association with the transport of lipids in blood. Apolipoproteins, plus phospholipids, cholesterol and triglycerides, form spherical particles with a lipid/hydrophobic center and a (apolipo)protein coat. The apolipoprotein coat promotes aqueous solubility and serves as a ligand for lipoprotein receptors. HDL may contain apolipoproteins A, C, D, E, J, L and M, while LDL contains apolipoproteins B and E.
ApoAI and ApoA2 are major protein components of serum high-density lipoprotein (HDL) and are produced by the liver and small intestine. They are involved in reverse cholesterol transport from tissues to the liver. Polymorphisms of ApoA2 are associated with disorders of cholesterol and fatty acid metabolism. Human ApoB (Apolipoprotein B-100) is a 550 kDa, secreted, palmitoylated glycoprotein that is part of LDL and VLDL particles. It is made by liver and is 4536 aa in length. It binds LDL to the ApoB/E receptor. ApoC activates lipoprotein lipase and may self-associate to form amyloid-type fibrils.
ApoE is a 34 kDa protein component of serum chylomicrons, VLDL, and HDL particles. It mediates the binding, uptake, and catabolism of these particles through interactions with the ApoE receptor and LDL receptors in the liver and brain. ApoE is important in fatty acid homeostasis and memory formation. Polymorphisms encode three variants (ApoE2, 3, 4) which are differentially related to the development of atherosclerosis and neurogenerative disorders, particularly Alzheimer's disease.
Serum amyloid A proteins (SAAs) are a family of homologous apolipoproteins of high density lipoprotein (HDL). They can be divided into two groups. The first group consists of the acute phase SAA1 and SAA2 that associate with HDL during inflammation and remodel the HDL particle by displacing apolipoprotein A1. The second group consists of constitutively expressed SAA4 and SAA5 that exist as minor apolipoproteins on HDL but make up more than 90% of the total SAA during homeostasis.
Citations for Human Apolipoprotein A-I Quantikine ELISA Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Plasma apolipopotein C-2 elevation is associated with Takayasu arteritis
Authors: N Tamura, Y Maejima, Y Shiheido-W, S Nakagama, M Isobe, T Sasano
Scientific Reports, 2021-09-23;11(1):18958.
Species: Human
Sample Types: Plasma
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MicroRNA-33 regulates the population of peripheral inflammatory Ly6Chigh monocytes through dual pathways
Authors: O Baba, T Horie, T Nakao, D Hakuno, Y Nakashima, H Nishi, Y Kuwabara, M Nishiga, T Nishino, Y Ide, F Nakazeki, S Koyama, M Kimura, R Hanada, M Kawahara, T Kimura, K Ono
Mol. Cell. Biol., 2018-06-28;0(0):.
Species: Mouse
Sample Types: Serum
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