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Human CCR7 Biotinylated Antibody

Catalog #: FAB197B
2 Citations Datasheet / COA / SDS
Clone 150503 was used by HLDA to establish CD designation
Catalog # Availability Size / Price Qty
FAB197B-100UG
Detection of CCR7 in Human PBMCs by Flow Cytomtetry.
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Citations (2)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CCR7 Biotinylated Antibody Summary

Species Reactivity
Human
Specificity
Detects human CCR7.
Source
Monoclonal Mouse IgG2A Clone # 150503
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human CCR7 transfectants
Met1-Pro378
Accession # AAA58615
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Biotin

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25-1 µg/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CCR7 antibody in Human PBMCs by Flow Cytomtetry. View Larger

Detection of CCR7 in Human PBMCs by Flow Cytomtetry. Human peripheral blood mononuclear cells (PBMCs) were stained with PE-conjugated Mouse anti-Human CD4 Monoclonal Antibody (Catalog # FAB3791P) and either (A) Mouse anti-Human CCR7 Biotinylated Monoclonal Antibody (Catalog # FAB197B) or (B) Mouse IgG2A isotype control antibody (Catalog # IC003B) followed by APC-conjugated Streptavidin (Catalog # F0040). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CCR7

CCR7 (Chemokine Receptor 7; also CD197) is a 7 transmembrane (7TM) G protein-coupled chemokine receptor for the homeostatic chemokines CCL19/MIP-3 beta and CCL21/6Ckine. CCL19 and CCL21 are constitutively expressed by high endothelial venule epithelial cells or fibroblastic reticular cells in secondary lymphoid organs. CCR7 is upregulated on dendritic cells, naïve and memory T cells, Treg, NK cells, and B cells following inflammatory stimulation. Its expression enables the function of immune cell trafficking to and retention in regional lymph nodes for expansion of the adaptive immune response. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.

Entrez Gene IDs
1236 (Human); 12775 (Mouse); 287673 (Rat)
Alternate Names
BLR2; BLR2C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR7; CCR-7; CD197 antigen; CD197; CDw197; CDw197CC chemokine receptor 7; chemokine (C-C motif) receptor 7; CMKBR7; CMKBR7chemokine (C-C) receptor 7; EBI1; EBI1EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus induced G-protein coupled receptor; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor

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Citations for Human CCR7 Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
    Authors: F Barrenäs, SG Hansen, L Law, C Driscoll, RR Green, E Smith, J Chang, I Golez, T Urion, X Peng, L Whitmore, D Newhouse, CM Hughes, D Morrow, KT Randall, AN Selseth, JC Ford, RM Gilbride, BE Randall, E Ainslie, K Oswald, R Shoemaker, R Fast, WJ Bosche, MK Axthelm, Y Fukazawa, GN Pavlakis, BK Felber, S Fourati, RP Sekaly, JD Lifson, J Komorowski, E Kosmider, D Shao, W Song, PT Edlefsen, LJ Picker, M Gale
    PloS Pathogens, 2021-07-06;17(7):e1009278.
    Species: Rhesus Macaque
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Early Induction of Polyfunctional Simian Immunodeficiency Virus (SIV)-Specific T Lymphocytes and Rapid Disappearance of SIV from Lymph Nodes of Sooty Mangabeys during Primary Infection.
    Authors: Meythaler M, Wang Z, Martinot A, Pryputniewicz S, Kasheta M, McClure HM, O'Neil SP, Kaur A
    J. Immunol., 2011-03-25;186(9):5151-61.
    Species: Primate - Cercocebus atys (Sooty Mangabey)
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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