Human CD25/IL-2R alpha (NP_000408) VersaClone cDNA

Human CD25/IL-2R alpha (NP_000408) VersaClone cDNA Summary

Specifications

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Background: CD25/IL-2R alpha

CD25/IL-2 receptor alpha is a transmembrane protein that associates with IL-2 R beta/CD122 and the Common gamma Chain/CD132 on activated T cells and regulatory T cells (Treg). The Common gamma chain is a shared subunit in the receptors for IL-4, -7, -9, -15, and -21. IL-2 R alpha is required for mediating IL-2 induced effects including T cell proliferation, activation induced cell death (AICD) of autoreactive naive T cells, and the development of CD4+CD25+ Treg which contribute to peripheral T cell homeostasis. A soluble form of IL-2 R alpha can be generated by proteolytic cleavage of the cell surface receptor.

Related Research Areas

• Acute Lymphoblastic Leukemia
• Acute Myeloid Leukemia
• B Cell Activation
• B Cell Markers
• Cancer Biomarkers
• Common gamma Chain Receptor Family
• Cytokines and Receptors in Allergy and Asthma
• Cytokines and Receptors in Tfh Cell Differentiation and Function
• Group 1 ILCs
• Group 2 ILCs
• Isolation, Culture, and Identification of Natural Killer Cells
• LTi Cells
• Lymphoma
• NCR+ILC3
• NCR-ILC3
• Preeclampsia
• Receptors in the Jak/STAT Pathway
• Regulatory T Cells (Tregs)
• T Cell Cytokine Signaling