Human CD31/PECAM-1 Antibody Summary
Extracellular domain
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human CD31/PECAM‑1 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human CD31/PECAM-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (HAF016). A specific band was detected for CD31/PECAM-1 at approximately 130 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
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CD31/PECAM‑1 in HUVECs. CD31/PECAM-1 was detected in immersion fixed HUVEC human umbilical vein endothelial cells using 10 µg/mL Sheep Anti-Human CD31/PECAM-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # NL010) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
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Detection of Human CD31/PECAM‑1 by Simple WesternTM. Simple Western lane view shows lysates of Jurkat human acute T cell leukemia cell line and HepG2 human hepatocellular carcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for CD31/PECAM-1 at approximately 173-186 kDa (as indicated) using 10 µg/mL of Sheep Anti-Human CD31/PECAM-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) followed by 1:50 dilution of HRP-conjugated Anti-Sheep IgG Secondary Antibody (HAF016). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
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CD31/PECAM‑1 Specificity is Shown by Immunocytochemistry in Knockout Cell Line. CD31/PECAM‑1 was detected in immersion fixed THP‑1 human acute monocytic leukemia cell line but is not detected in CD31/PECAM‑1 knockout (KO) THP‑1 human cell line using Sheep Anti-Human CD31/PECAM‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) at 5 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; NL010) and counterstained with DAPI (blue). Specific staining was localized to cell membrane. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.
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Detection of CD31/PECAM‑1 in human liver. CD31/PECAM‑1 was detected in immersion fixed paraffin-embedded sections of human liver using Sheep Anti-Human CD31/PECAM‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to endothelial cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
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Detection of CD31/PECAM‑1 in human liver. CD31/PECAM‑1 was detected in immersion fixed paraffin-embedded sections of human liver using Sheep Anti-Human CD31/PECAM‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to endothelial cells and sinusoids. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
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Detection of Human CD31/PECAM-1 by Immunocytochemistry/Immunofluorescence Expression pattern of integrin receptors and type IV collagen in normal pancreatic tissue. A. H&E staining of normal exocrine pancreas with acini structures and a duct in the insert. The area shown is representative for all panels in B. B. Merged immunofluorescence staining of integrin alpha 1, alpha 2, and beta 1 (in red), and type IV collagen (green in upper row), or the endothelial marker CD31 (green in lower row). Type IV collagen is present in the vascular-, ductal-, and acini-BMs. Integrin alpha 1 is only expressed in endothelial cells and integrin alpha 2 only in the ductal epithelium. Integrin beta 1 is found in the ductal-, endothelial-, and at the base of the acini-cells. Arrows indicate examples of colocalization. Magnification x40 in all panels. Cell nuclei are stained by DAPI (in blue). Image collected and cropped by CiteAb from the following publication (https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-13-154), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CD31/PECAM-1
The CD31 adhesion molecule, also known as PECAM-1, is expressed in large amounts on endothelial cells at intercellular junctions and on T cell subsets, and to a lesser extent on platelets and most other leukocytes such as monocytes and neutrophils. CD31 binds to itself homotypically, and also to the leukocyte integrin alpha v beta 3 heterotypically. CD31 is required for the transendothelial migration of leukocytes through intercellular junctions of vascular endothelial cells. CD31 has been found in human plasma, and the presence of this circulating isoform is suggested to modulate the transendothelial migration of leukocytes.
Product Datasheets
Citations for Human CD31/PECAM-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke
Authors: Lyu Z, Park J, Kim KM Et al.
Nature biomedical engineering
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SARS-CoV-2 infection induces beta cell transdifferentiation
Authors: Tang X, Uhl S, Zhang T et al.
Cell Metabolism
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SOX4 promotes vascular abnormality in glioblastoma and is a novel target to improve drug delivery
Authors: Yao, K;Yang, M;Shu, M;Wang, T;Gao, D;Zhou, L;Wang, G;Zhang, Z;Tang, J;
Translational oncology
Species: Mouse
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic ? cell Pyroptosis upon Viral Infection
Authors: Yang, L;Han, Y;Zhang, T;Dong, X;Ge, J;Roy, A;Zhu, J;Lu, T;Vandana, JJ;de Silva, N;Robertson, CC;Xiang, JZ;Pan, C;Sun, Y;Que, J;Evans, T;Liu, C;Wang, W;Naji, A;Parker, SCJ;Schwartz, RE;Chen, S;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Immunocytochemistry -
Engineered human iPS cell models reveal altered podocytogenesis and glomerular capillary wall in CHD-associated SMAD2 mutations
Authors: Bhattacharya, R;Ward, T;Kalejaiye, TD;Mishra, A;Leeman, S;Arzaghi, H;Seidman, JG;Seidman, CE;Musah, S;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Immunocytochemistry -
Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence
Authors: Li, B;Xiong, W;Zuo, W;Shi, Y;Wang, T;Chang, L;Wu, Y;Ma, H;Bian, Q;Chang, ACY;
Nucleic acids research
Species: Human
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Dietary emulsifier polysorbate 80 exposure accelerates age-related cognitive decline
Authors: Zhang, L;Yin, Z;Liu, X;Jin, G;Wang, Y;He, L;Li, M;Pang, X;Yan, B;Jia, Z;Ma, J;Wei, J;Cheng, F;Li, D;Wang, L;Han, Z;Liu, Q;Chen, F;Cao, H;Lei, P;
Brain, behavior, and immunity
Species: Mouse
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Multisensory gamma stimulation promotes glymphatic clearance of amyloid
Authors: Murdock, MH;Yang, CY;Sun, N;Pao, PC;Blanco-Duque, C;Kahn, MC;Kim, T;Lavoie, NS;Victor, MB;Islam, MR;Galiana, F;Leary, N;Wang, S;Bubnys, A;Ma, E;Akay, LA;Sneve, M;Qian, Y;Lai, C;McCarthy, MM;Kopell, N;Kellis, M;Piatkevich, KD;Boyden, ES;Tsai, LH;
Nature
Species: Human
Sample Types: Organoid
Applications: Immunohistochemistry -
Generation of complex bone marrow organoids from human induced pluripotent stem cells
Authors: Frenz-Wiessner, S;Fairley, SD;Buser, M;Goek, I;Salewskij, K;Jonsson, G;Illig, D;Zu Putlitz, B;Petersheim, D;Li, Y;Chen, PH;Kalauz, M;Conca, R;Sterr, M;Geuder, J;Mizoguchi, Y;Megens, RTA;Linder, MI;Kotlarz, D;Rudelius, M;Penninger, JM;Marr, C;Klein, C;
Nature methods
Species: Human, Xenograft
Sample Types: Organoid, Whole Tissue
Applications: Immunohistochemistry -
Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular Arrhythmias
Authors: Raval, AN;Schmuck, EG;Roy, S;Saito, Y;Zhou, T;Conklin, J;Hacker, TA;Koonce, C;Boyer, M;Stack, K;Hebron, E;Nagle, SK;Hsieh, PCH;Kamp, TJ;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Immunocytochemistry -
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1?/ASK1/JNK signaling pathway in mice with traumatic brain injury
Authors: Shi, G;Liu, L;Cao, Y;Ma, G;Zhu, Y;Xu, J;Zhang, X;Li, T;Mi, L;Jia, H;Zhang, Y;Liu, X;Zhou, Y;Li, S;Yang, G;Liu, X;Chen, F;Wang, B;Deng, Q;Zhang, S;Zhang, J;
Journal of neuroinflammation
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Acute Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy Is Associated with Placental Angiotensin-Converting Enzyme 2 Shedding
Authors: Elizabeth S. Taglauer, Elisha M. Wachman, Lillian Juttukonda, Timothy Klouda, Jiwon Kim, Qiong Wang et al.
The American Journal of Pathology
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Multi-omics profiling visualizes dynamics of cardiac development and functions
Authors: Y Gu, Y Zhou, S Ju, X Liu, Z Zhang, J Guo, J Gao, J Zang, H Sun, Q Chen, J Wang, J Xu, Y Xu, Y Chen, Y Guo, J Dai, H Ma, C Wang, G Jin, C Li, Y Xia, H Shen, Y Yang, X Guo, Z Hu
Cell Reports, 2022-12-27;41(13):111891.
Species: Mouse
Sample Types: Whole Cells
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Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities
Authors: JKE Spetz, MHC Florido, CS Fraser, X Qin, J Choiniere, SJ Yu, R Singh, M Friesen, LL Rubin, JE Salem, JJ Moslehi, KA Sarosiek
Science Advances, 2022-11-09;8(45):eabn6579.
Species: Human, Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC -
Angiogenic stem cell delivery platform to augment post-infarction neovasculature and reverse ventricular remodeling
Authors: Shin HS, Thakore A, Tada Y et al.
Scientific Reports
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Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke
Authors: Qi Zhang, Chang Liu, Rubing Shi, Shiyi Zhou, Huimin Shan, Lidong Deng et al.
Aging and disease
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Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy
Authors: Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucia Carrau, André Figueiredo Rendeiro et al.
iScience
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Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2
Authors: Timothy Klouda, Yuan Hao, Hyunbum Kim, Jiwon Kim, Judith Olejnik, Adam J. Hume et al.
Angiogenesis
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Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance
Authors: Kelvin Yin, Daniel Patten, Sarah Gough, Susana de Barros Gonçalves, Adelyne Chan, Ioana Olan et al.
Genes & Development
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Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy
Authors: Alexandra R. Harris, Savieay Esparza, Mohammad S. Azimi, Robert Cornelison, Francesca N. Azar, Danielle C. Llaneza et al.
Frontiers in Oncology
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Short-Term Supplementation With Fermented Red Clover Extract Reduces Vascular Inflammation in Early Post-menopausal Women
Authors: Kate A. Wickham, Line B. Nørregaard, Mikkel Oxfeldt, Stephen S. Cheung, Lasse Gliemann, Mette Hansen et al.
Frontiers in Cardiovascular Medicine
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Pharmacokinetic Developability and Disposition Profiles of Bispecific Antibodies: A Case Study with Two Molecules
Authors: Amita Datta-Mannan, Robin Brown, Stephanie Key, Paul Cain, Yiqing Feng
Antibodies (Basel)
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Hydrogels Containing Gradients in Vascular Density Reveal Dose‐Dependent Role of Angiocrine Cues on Stem Cell Behavior
Authors: Mai T. Ngo, Victoria R. Barnhouse, Aidan E. Gilchrist, Bhushan P. Mahadik, Christine J. Hunter, Joy N. Hensold et al.
Advanced Functional Materials
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A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium
Authors: Y Roye, R Bhattachar, X Mou, Y Zhou, MA Burt, S Musah
Micromachines, 2021-08-16;12(8):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing
Authors: Y Xie, L He, R Lugano, Y Zhang, H Cao, Q He, M Chao, B Liu, Q Cao, J Wang, Y Jiao, Y Hu, L Han, Y Zhang, H Huang, L Uhrbom, C Betsholtz, L Wang, A Dimberg, L Zhang
JCI Insight, 2021-08-09;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta
Authors: LB Argueta, LA Lacko, Y Bram, T Tada, L Carrau, T Zhang, S Uhl, BC Lubor, V Chandar, C Gil, W Zhang, B Dodson, J Bastiaans, M Prabhu, CM Salvatore, YJ Yang, RN Baergen, BR tenOever, NR Landau, S Chen, RE Schwartz, H Stuhlmann
bioRxiv : the preprint server for biology, 2021-06-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS
Authors: YG Gete, LW Koblan, X Mao, M Trappio, B Mahadik, JP Fisher, DR Liu, K Cao
Aging Cell, 2021-06-04;0(0):e13388.
Species: Human
Sample Types: Cell Lysates, Whole Cells
Applications: IHC, Western Blot -
In Vitro Prevascularization of Self-Assembled Human Bone-Like Tissues and Preclinical Assessment Using a Rat Calvarial Bone Defect Model
Authors: Fabien Kawecki, Todd Galbraith, William P. Clafshenkel, Michel Fortin, François A. Auger, Julie Fradette
Materials (Basel)
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3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration
Authors: KV Manian, CA Galloway, S Dalvi, AA Emanuel, JA Mereness, W Black, L Winschel, C Soto, Y Li, Y Song, W DeMaria, A Kumar, I Slukvin, MP Schwartz, WL Murphy, B Anand-Apte, M Chung, DSW Benoit, R Singh
Cell Stem Cell, 2021-03-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells
Authors: G Campostrin, V Meraviglia, E Giacomelli, RWJ van Helden, L Yiangou, RP Davis, M Bellin, VV Orlova, CL Mummery
Nature Protocols, 2021-03-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry, ICC -
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development
Authors: EI Crosse, S Gordon-Key, S Rybtsov, A Binagui-Ca, H Felchle, NC Nnadi, K Kirschner, T Chandra, S Tamagno, DJ Webb, F Rossi, RA Anderson, A Medvinsky
Cell Stem Cell, 2020-09-17;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu
Authors: Dongdong Zhang, Andrew J. Kinloch, Abhinav Srinath, Robert Shenkar, Romuald Girard, Rhonda Lightle et al.
Journal of Autoimmunity
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Abnormal Microvascular Architecture, Fibrosis, and Pericyte Characteristics in the Calf Muscle of Peripheral Artery Disease Patients with Claudication and Critical Limb Ischemia
Authors: CJ Mietus, TJ Lackner, PS Karvelis, GT Willcockso, CM Shields, NG Lambert, P Koutakis, MA Fuglestad, H Hernandez, GR Haynatzki, JKS Kim, HK DeSpiegela, II Pipinos, GP Casale
J Clin Med, 2020-08-08;9(8):.
Species: Bovine, Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC -
Metabolic response of blood vessels to TNF alpha
Authors: Abidemi Junaid, Johannes Schoeman, Wei Yang, Wendy Stam, Alireza Mashaghi, Anton Jan van Zonneveld et al.
eLife
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A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
Species: Human
Sample Types: Organoids, Whole Cells
Applications: ICC, IHC -
Conditioned medium produced by fibroblasts cultured in low oxygen pressure allows the formation of highly structured capillary-like networks in fibrin gels
Authors: C Caneparo, C Baratange, S Chabaud, S Bolduc
Sci Rep, 2020-06-09;10(1):9291.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes
Authors: JW Blanchard, M Bula, J Davila-Vel, LA Akay, L Zhu, A Frank, MB Victor, JM Bonner, H Mathys, YT Lin, T Ko, DA Bennett, HP Cam, M Kellis, LH Tsai
Nat. Med., 2020-06-08;26(6):952-963.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease
Authors: E Giacomelli, V Meraviglia, G Campostrin, A Cochrane, X Cao, RWJ van Helden, A Krotenberg, M Mircea, S Kostidis, RP Davis, BJ van Meer, CR Jost, AJ Koster, H Mei, DG Míguez, AA Mulder, M Ledesma-Te, G Pompilio, L Sala, DCF Salvatori, RC Slieker, E Sommariva, AAF de Vries, M Giera, S Semrau, LGJ Tertoolen, VV Orlova, M Bellin, CL Mummery
Cell Stem Cell, 2020-05-26;26(6):862-879.e11.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Daily Ethanol Drinking Followed by an Abstinence Period Impairs Bone Marrow Niche and Mitochondrial Function of Hematopoietic Stem/Progenitor Cells in Rhesus Macaques
Authors: Oleg Varlamov, Matthew Bucher, Leslie Myatt, Natali Newman, Kathleen A. Grant
Alcoholism: Clinical and Experimental Research
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Spatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques
Authors: Jacob J. Robino, Nathalie Pamir, Sara Rosario, Lindsey B. Crawford, Benjamin J. Burwitz, Charles T. Roberts et al.
Bone
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A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
Cell Stem Cell, 2020;27(1):125-136.e7.
Species: Human
Sample Types: Organoids
Applications: IHC -
Platelets, endothelial cells and leukocytes contribute to the exercise-triggered release of extracellular vesicles into the circulation
Authors: Alexandra Brahmer, Elmo Neuberger, Leona Esch-Heisser, Nils Haller, Malene Moeller Jorgensen, Rikke Baek et al.
Journal of Extracellular Vesicles
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Mineral deposition and vascular invasion of hydroxyapatite reinforced collagen scaffolds seeded with human adipose-derived stem cells
Authors: HE Weiss-Bilk, MJ Meagher, JA Gargac, GL Niebur, RK Roeder, DR Wagner
Biomater Res, 2019-10-17;23(0):15.
Species: Human
Sample Types: Whole Cells
Applications: Flourescense Microscopy -
Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition
Authors: JM Elsakr, JC Dunn, K Tennant, SK Zhao, K Kroeten, RC Pasek, DL Takahashi, TA Dean, DR Velez Edwa, CE McCurdy, KM Aagaard, AC Powers, JE Friedman, P Kievit, M Gannon
Mol Metab, 2019-04-12;0(0):.
Species: Primate - Macaca fuscata (Japanese Macaque)
Sample Types: Whole Tissue
Applications: IHC-P -
Expression and localisation of thymosin beta-4 in the developing human early fetal heart
Authors: Vinay Saunders, Jennifer M. Dewing, Tilman Sanchez-Elsner, David I. Wilson
PLOS ONE
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Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development
Authors: J Bourland, J Fradette, FA Auger
Sci Rep, 2018-09-04;8(1):13191.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration
Authors: Angela Rey-Gallardo, Hannah Tomlins, Justin Joachim, Izajur Rahman, Phoebe Kitscha, Karen Frudd et al.
Journal of Cell Science
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Circulating Vascular Basement Membrane Fragments are Associated with the Diameter of the Abdominal Aorta and Their Expression Pattern is Altered in AAA Tissue
Authors: M Holsti, A Wanhainen, C Lundin, M Björck, G Tegler, J Svensson, M Sund
Eur J Vasc Endovasc Surg, 2018-04-12;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Leucine-Rich ?-2-Glycoprotein-1 (LRG-1) Expression in Retinoblastoma
Authors: R Amer, L Tiosano, J Pe'er
Invest. Ophthalmol. Vis. Sci., 2018-02-01;59(2):685-692.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Tissue-engineered 3D human lymphatic microvascular network for in vitro studies of lymphangiogenesis
Authors: L Gibot, T Galbraith, J Bourland, A Rogic, M Skobe, FA Auger
Nat Protoc, 2017-04-27;12(5):1077-1088.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells
Sci Rep, 2016-11-02;6(0):35680.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Adjuvant capecitabine plus bevacizumab versus capecitabine alone in patients with colorectal cancer (QUASAR 2): an open-label, randomised phase 3 trial
Authors: Rachel S Kerr, Sharon Love, Eva Segelov, Elaine Johnstone, Beverly Falcon, Peter Hewett et al.
The Lancet Oncology
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Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys
Authors: A Datta-Mann, JE Croy, L Schirtzing, S Torgerson, M Breyer, VJ Wroblewski
MAbs, 2016-07-01;8(5):969-82.
Species: Primate
Sample Types: Whole Cells
Applications: ICC -
Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression
Authors: Madeleine J. Oudin, Shannon K. Hughes, Nazanin Rohani, Mira N. Moufarrej, Joan G. Jones, John S. Condeelis et al.
Clinical & Experimental Metastasis
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Cell-based approach for 3D reconstruction of lymphatic capillaries in vitro reveals distinct functions of HGF and VEGF-C in lymphangiogenesis
Authors: Laure Gibot, Todd Galbraith, Bryan Kloos, Suvendu Das, Dan A. Lacroix, François A. Auger et al.
Biomaterials
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Oxidative activity of 17 beta -hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17 beta -HSD type 2
Authors: Mohamed Fouad Mansour, Mélissa Pelletier, Marie-Michèle Boulet, Dominique Mayrand, Gaétan Brochu, Stefane Lebel et al.
Molecular and Cellular Endocrinology
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TGF-beta1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.
Authors: Pang M, Georgoudaki A, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander J, Nelson C, Jakobsson L, Betsholtz C, Sund M, Karlsson M, Fuxe J
Oncogene, 2015-05-11;35(6):748-60.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology.
Authors: Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, Ricci-Vitiani L, D'Alessandris Q, Morgante L, Giannetti S, Larocca L, Todaro M, Benfante A, Colorito M, Stassi G, De Maria R, Rowlinson S, Stancato L
PLoS ONE, 2015-04-28;10(4):e0125697.
Species: Human
Sample Types: Whole Cells
Applications: IHC-Fr -
Creating capillary networks within human engineered tissues: Impact of adipocytes and their secretory products
Authors: Kim Aubin, Caroline Vincent, Maryse Proulx, Dominique Mayrand, Julie Fradette
Acta Biomaterialia
Species: Human
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells.
Authors: Crosley, Erin J, Dunk, Caroline, Beristain, Alexande, Christians, Julian K
Reprod Biol Endocrinol, 2014-12-04;12(0):123.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese macaque model.
Authors: Pound L, Comstock S, Grove K
Am J Physiol Endocrinol Metab, 2014-05-20;307(1):E115-23.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Tissue
Applications: IHC-P -
A method to assess target gene involvement in angiogenesis in vitro and in vivo using lentiviral vectors expressing shRNA.
Authors: Blosser, Wayne, Vakana, Eliza, Wyss, Lisa V, Swearingen, Michelle, Stewart, Julie, Stancato, Louis, Tate, Courtney
PLoS ONE, 2014-04-23;9(4):e96036.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
miR-27a regulates endothelial differentiation of breast cancer stem like cells.
Authors: Tang, W, Yu, F, Yao, H, Cui, X, Jiao, Y, Lin, L, Chen, J, Yin, D, Song, E, Liu, Q
Oncogene, 2013-06-10;33(20):2629-38.
Species: Human
Sample Types: Cell Lysates, Whole Cells, Whole Tissue
Applications: ICC, IHC-Fr, Western Blot -
Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop.
Authors: Ohlund D, Franklin O, Lundberg E, Lundin C, Sund M
BMC Cancer, 2013-03-26;13(0):154.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-Fr -
Maternal high-fat diet impacts endothelial function in nonhuman primate offspring.
Authors: Fan, L, Lindsley, S R, Comstock, S M, Takahashi, D L, Evans, A E, He, G-W, Thornburg, K L, Grove, K L
Int J Obes (Lond), 2012-03-27;37(2):254-62.
Species: Primate - Macaca fuscata (Japanese Macaque)
Sample Types: Whole Tissue
Applications: IHC-P -
Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures.
Authors: Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C, Willeit J, Steiner M, Breuss J, Xu Q, Kiechl S, Mayr M
Blood, 2009-04-15;114(3):723-32.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Signaling hierarchy regulating human endothelial cell development.
Authors: Kelly MA, Hirschi KK
Arterioscler. Thromb. Vasc. Biol., 2009-02-12;29(5):718-24.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
Authors: Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, Marx SJ, Spiegel AM, Libutti SK
Cancer Res., 2009-02-10;69(5):1858-66.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
The Endothelial Mechanotransduction Protein Platelet Endothelial Cell Adhesion Molecule-1 Is Influenced by Aging and Exercise Training in Human Skeletal Muscle.
Authors: Gliemann L, Rytter N, Piil P et al.
Front Physiol
-
Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody
Authors: G Jo, J Bae, HJ Hong, AR Han, DK Kim, SP Hong, JA Kim, S Lee, GY Koh, HM Kim
Nature Communications, 2021-11-01;12(1):6287.
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