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Human Complement Factor I Antibody

Catalog #: MAB3307
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB3307
MAB3307-SP
Product Details
Citations (3)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Complement Factor I Antibody Summary

Species Reactivity
Human
Specificity
Detects human Complement Factor I in direct ELISAs and Western blots.
Source
Monoclonal Mouse IgG1 Clone # 271203
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Complement Factor I
Lys19-Val583
Accession # P05156
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Complement Factor I
Immunoprecipitation
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human Complement Factor I, see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Complement Factor I

Factor I is a secreted serine protease present in human plasma. It specifically cleaves and inactivates complement subcomponents C3b, iC3b, and C4b.

Entrez Gene IDs
3426 (Human)
Alternate Names
AHUS3; C3b Inactivator; C3B/C4B inactivator; C3BINA; C3b-inactivator; CFI; complement component I; complement control protein factor I; complement factor I heavy chain; Complement Factor I; EC 3.4.21; EC 3.4.21.45; FIC3b-INA; I factor (complement); IF; KAF; Konglutinogen-activating factor; light chain of factor I

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Citations for Human Complement Factor I Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Bruch's Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration
    Authors: SJ Clark, S McHarg, V Tilakaratn, N Brace, PN Bishop
    Front Immunol, 2017-12-19;8(0):1778.
    Species: Human
    Sample Types: Serum
    Applications: Western Blot
  2. A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b.
    Authors: Johnson J, Borisevich V, Rockx B, Parks G
    J Virol, 2014-10-29;89(2):989-98.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. Verapamil‐containing silicone gel reduces scar hypertrophy
    Authors: Jangyoun Choi, Yu Na Han, Eun Young Rha, Hwi Ju Kang, Ki Joo Kim, Il Kyu Park et al.
    International Wound Journal

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