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Human CXCR4 PE-conjugated Antibody

Catalog #: FAB170P
40 Citations 10 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB170P-025
FAB170P-100
Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry.
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Product Details
Citations (40)
FAQs
Supplemental Products
Reviews (10)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CXCR4 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human CXCR4.
Source
Monoclonal Mouse IgG2A Clone # 12G5
Purification
Protein A or G purified from ascites
Immunogen
CP-MAC-infected SUP-T1 human T cell lymphoblastic lymphoma line
Accession # P61073
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
see below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CXCR4 antibody in Human Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CXCR4 PE-conjugated Monoclonal Antibody (Catalog # FAB170P) and Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (FAB4867A) for 15 minutes at 37°C followed by 15 minutes at room temperature. View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry View Larger

Detection of CXCR4 in Jurkat vs K562 cells by Flow Cytometry Jurkat (filled histogram) vs K562 (open histogram) cells were stained with Mouse Anti-Human CXCR4 PE‑conjugated Monoclonal Antibody (Catalog # FAB170P). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CXCR4

CXCR4, also known as CD184, is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells.

References
  1. Endres, M.J. et al. (1996) Cell 87:745.
Long Name
C-X-C Motif Chemokine Receptor 4
Entrez Gene IDs
7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)
Alternate Names
CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXCR4; CXC-R4; CXCR-4; D2S201E; D2S201ESDF-1 receptor; FB22; Fusin; HM89; HM89NPYRL; HSY3RR; LAP3; LAP-3; LCR1; LESTR; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3R; NPY3RWHIM; NPYR; NPYRL; NPYY3R; pCXCR4; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor; WHIMS

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Citations for Human CXCR4 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

40 Citations: Showing 1 - 10
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  1. Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases
    Authors: Luigi Portella, Rosamaria Vitale, Stefania De Luca, Crescenzo D’Alterio, Caterina Ieranò, Maria Napolitano et al.
    PLoS ONE
  2. Generation of Complete Multi−Cell Type Lung Organoids From Human Embryonic and Patient‐Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation
    Authors: Sandra L. Leibel, Rachael N. McVicar, Alicia M. Winquist, Walter D. Niles, Evan Y. Snyder
    Current Protocols in Stem Cell Biology
  3. Bovine Organospecific Microvascular Endothelial Cell Lines as New and Relevant In Vitro Models to Study Viral Infections
    Authors: Anne-Claire Lagrée, Fabienne Fasani, Clotilde Rouxel, Marine Pivet, Marie Pourcelot, Aurore Fablet et al.
    International Journal of Molecular Sciences
  4. Conformational Ensembles Explored Dynamically from Disordered Peptides Targeting Chemokine Receptor CXCR4
    Authors: Marian Vincenzi, Susan Costantini, Stefania Scala, Diego Tesauro, Antonella Accardo, Marilisa Leone et al.
    International Journal of Molecular Sciences
  5. The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell–Attracting Cytokines
    Authors: Patrick M. Perrigue, Michael E. Silva, Charles D. Warden, Nathan L. Feng, Michael A. Reid, Daniel J. Mota et al.
    Molecular Cancer Research
  6. Recapitulating thyroid cancer histotypes through engineering embryonic stem cells
    Authors: V Veschi, A Turdo, C Modica, F Verona, S Di Franco, M Gaggianesi, E Tirrò, S Di Bella, ML Iacono, VD Pantina, G Porcelli, LR Mangiapane, P Bianca, A Rizzo, E Sciacca, I Pillitteri, V Vella, A Belfiore, MR Bongiorno, G Pistone, L Memeo, L Colarossi, D Giuffrida, C Colarossi, P Vigneri, M Todaro, G Stassi
    Nature Communications, 2023-03-11;14(1):1351.
  7. Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain
    Authors: García-Cuesta, EM;Martínez, P;Selvaraju, K;Ulltjärn, G;Gómez Pozo, AM;D'Agostino, G;Gardeta, S;Quijada-Freire, A;Blanco Gabella, P;Roca, C;Hoyo, DD;Jiménez-Saiz, R;García-Rubia, A;Soler Palacios, B;Lucas, P;Ayala-Bueno, R;Santander Acerete, N;Carrasco, Y;Oscar Sorzano, C;Martinez, A;Campillo, NE;Jensen, LD;Rodriguez Frade, JM;Santiago, C;Mellado, M;
    eLife
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. CXCL12-loaded-hydrogel (CLG): A new device for metastatic circulating tumor cells (CTCs) capturing and characterization
    Authors: Portella, L;Bertolini, G;Guardascione, G;Di Febbraro, DG;Ieranò, C;D'Alterio, C;Rea, G;Napolitano, M;Santagata, S;Trotta, AM;Camerlingo, R;Scarpa, E;Cecere, SC;Ottaiano, A;Palumbo, G;Morabito, A;Somma, T;De Rosa, G;Mayol, L;Pacelli, R;Pignata, S;Scala, S;
    Heliyon
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites
    Authors: Trotta, AM;Tomassi, S;Di Maiolo, G;Ieranò, C;Vetrei, C;D'Alterio, C;Merlino, F;Messere, A;D'Aniello, A;Del Bene, A;Mazzarella, V;Roggia, M;Natale, B;Cutolo, R;Campagna, E;Mottola, S;Russo, R;Chambery, A;Benedetti, R;Altucci, L;Cosconati, S;Scala, S;Di Maro, S;
    European journal of medicinal chemistry
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
    Authors: Garrido-Trigo, A;Corraliza, AM;Veny, M;Dotti, I;Melón-Ardanaz, E;Rill, A;Crowell, HL;Corbí, Á;Gudiño, V;Esteller, M;Álvarez-Teubel, I;Aguilar, D;Masamunt, MC;Killingbeck, E;Kim, Y;Leon, M;Visvanathan, S;Marchese, D;Caratù, G;Martin-Cardona, A;Esteve, M;Panés, J;Ricart, E;Mereu, E;Heyn, H;Salas, A;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Computationally designed GPCR quaternary structures bias signaling pathway activation
    Authors: JS Paradis, X Feng, B Murat, RE Jefferson, B Sokrat, M Szpakowska, M Hogue, ND Bergkamp, FM Heydenreic, MJ Smit, A Chevigné, M Bouvier, P Barth
    Nature Communications, 2022-11-11;13(1):6826.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Co-Expression of CD34, CD90, OV-6 and Cell-Surface Vimentin Defines Cancer Stem Cells of Hepatoblastoma, Which Are Affected by Hsp90 Inhibitor 17-AAG
    Authors: M Lee-Theile, JR Hadhoud, G Volante, DD Fadini, J Eichhorn, U Rolle, HC Fiegel
    Cells, 2021-09-29;10(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor
    Authors: S Tan, W Li, Z Li, Y Li, J Luo, L Yu, J Yang, M Qiu, H Cheng, W Xu, S Jiang, L Lu, S Liu, W Ma
    Viruses, 2019-09-18;11(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12
    Authors: I Del Molino, GC Wilkins, A Meeson, S Ali, JA Kirby
    Int J Mol Sci, 2018-11-14;19(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  15. Precardiac organoids form two heart fields via Bmp/Wnt signaling
    Authors: P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon
    Nat Commun, 2018-08-07;9(1):3140.
  16. Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis
    Authors: I Aversa, F Zolea, C Ieranò, S Bulotta, AM Trotta, MC Faniello, C De Marco, D Malanga, F Biamonte, G Viglietto, G Cuda, S Scala, F Costanzo
    J. Exp. Clin. Cancer Res., 2017-08-03;36(1):104.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering
    PLoS ONE, 2016-11-30;11(11):e0167056.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  18. PI3K/mTORC2 regulates TGF-beta/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.
    Authors: Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, Cui W
    Nat Commun, 2015-05-22;6(0):7212.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  19. Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines.
    Authors: Shankar V, Hori H, Kihira K, Lei Q, Toyoda H, Iwamoto S, Komada Y
    PLoS ONE, 2015-03-16;10(3):e0120069.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  20. IL-24 inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis.
    Authors: Panneerselvam J, Jin J, Shanker M, Lauderdale J, Bates J, Wang Q, Zhao Y, Archibald S, Hubin T, Ramesh R
    PLoS ONE, 2015-03-16;10(3):e0122439.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  21. The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cells in patients with multiple myeloma.
    Authors: Peled A, Abraham M, Avivi I, Rowe J, Beider K, Wald H, Tiomkin L, Ribakovsky L, Riback Y, Ramati Y, Aviel S, Galun E, Shaw H, Eizenberg O, Hardan I, Shimoni A, Nagler A
    Clin Cancer Res, 2013-11-18;20(2):469-79.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  22. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.
    Authors: Goldman O, Han S, Sourisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton D, Bissig K, Kalir T, Jacobs A, Evans T, Evans M, Gouon-Evans V
    Cell Stem Cell, 2013-06-06;12(6):748-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  23. Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors.
    Authors: Cerdeira A, Rajakumar A, Royle C, Lo A, Husain Z, Thadhani R, Sukhatme V, Karumanchi S, Kopcow H
    J Immunol, 2013-03-13;190(8):3939-48.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  24. CXCR4 positive and angiogenic monocytes in myocardial infarction.
    Thromb Haemost, 2012-12-06;109(2):255-62.
    Species: Human
    Sample Types: Whole Blood
    Applications: Flow Cytometry
  25. A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.
    Authors: Bone HK, Nelson AS, Goldring CE, Tosh D, Welham MJ
    J. Cell. Sci., 2011-05-24;124(0):1992-2000.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  26. Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology.
    Authors: Shantsila E, Wrigley B, Tapp L, Apostolakis S, Montoro-Garcia S, Drayson MT, Lip GY
    J. Thromb. Haemost., 2011-05-01;9(5):1056-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  27. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
    Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
    J. Immunol., 2010-02-17;184(6):2886-98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  28. Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma.
    Authors: Levings PP, McGarry SV, Currie TP, Nickerson DM, McClellan S, Ghivizzani SC, Steindler DA, Gibbs CP
    Cancer Res., 2009-07-07;69(14):5648-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  29. A Novel Approach for the Derivation of Putative Primordial Germ Cells and Sertoli Cells from Human Embryonic Stem Cells.
    Authors: Bucay N, Yebra M, Cirulli V, Afrikanova I, Kaido T, Hayek A, Montgomery AM
    Stem Cells, 2009-01-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  30. Chemokine-mediated migration of skin-derived stem cells: predominant role for CCL5/RANTES.
    Authors: Kroeze KL, Jurgens WJ, Doulabi BZ, van Milligen FJ, Scheper RJ, Gibbs S
    J. Invest. Dermatol., 2009-01-01;129(6):1569-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  31. Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
    Authors: Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA
    J. Neuroimmunol., 2008-06-09;199(1):35-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  32. Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
    Authors: Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H
    Cardiovasc. Res., 2006-05-09;71(3):455-65.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  33. Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
    Authors: Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK
    Int. J. Cancer, 2006-05-01;118(9):2147-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  34. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion.
    Authors: Singh S, Singh UP, Grizzle WE, Lillard JW
    Lab. Invest., 2004-12-01;84(12):1666-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  35. Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.
    Authors: Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A
    Blood, 2004-09-28;105(3):931-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  36. Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge.
    Authors: Liu LY, Jarjour NN, Busse WW, Kelly EA
    J. Allergy Clin. Immunol., 2003-09-01;112(3):556-62.
    Species: Human
    Sample Types: BALF
    Applications: Flow Cytometry
  37. Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells
    Authors: Justyna Magdalena Kowal, Sören Möller, Dalia Ali, Florence Figeac, Torben Barington, Hagen Schmal et al.
    Stem Cell Research & Therapy
  38. Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4
    Authors: Patricia A Cronin, Jiang H Wang, H Paul Redmond
    BMC Cancer
  39. MARVEL domain containing CMTM4 affects CXCR4 trafficking
    Authors: Alexandra Bona, Michael Seifert, Roland Thünauer, Kyra Zodel, Ian J. Frew, Winfried Römer et al.
    Molecular Biology of the Cell
  40. CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells
    Authors: Tingting Cheng, Kui Zhai, Yan Chang, Guidong Yao, Jiahuan He, Fang Wang et al.
    Oncotarget

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Reviews for Human CXCR4 PE-conjugated Antibody

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Human CXCR4 PE-conjugated Antibody
By Anonymous on 03/30/2018
Application: Flow Sample Tested: Jurkat human acute T cell leukemia cell line Species: Human
Human CXCR4 PE-conjugated Antibody
By Anonymous on 03/15/2018
Application: Flow Sample Tested: Jurkat human acute T cell leukemia cell line Species: Human
Human CXCR4 PE-conjugated Antibody
By Anonymous on 03/12/2018
Application: Flow Sample Tested: MDA-MB-231 human breast cancer cell line Species: Human
Human CXCR4 PE-conjugated Antibody
By Anonymous on 11/27/2017
Application: Flow Sample Tested: MDA-MB-231 human breast cancer cell line Species: Human
Flow Cytometry Human CXCR4 PE-conjugated Antibody FAB170P
Human CXCR4 PE-conjugated Antibody
By Anonymous on 11/20/2017
Application: Flow Sample Tested: MCF7 Species: Human
Flow Cytometry Human CXCR4 PE-conjugated Antibody FAB170P
Human CXCR4 PE-conjugated Antibody
By Anonymous on 11/10/2017
Application: Flow Sample Tested: Jurkat human acute T cell leukemia cell line Species: Human
Human CXCR4 PE-conjugated Antibody
By Anonymous on 11/06/2017
Application: Flow Sample Tested: CHO Chinese hamster ovary cell line Species: Human
Flow Cytometry Human CXCR4 PE-conjugated Antibody FAB170P
Human CXCR4 PE-conjugated Antibody
By Anonymous on 08/15/2017
Application: Flow Sample Tested: U87 CXCR4 transfected cells Species: Human
Flow Cytometry Human CXCR4 PE-conjugated Antibody FAB170P
Human CXCR4 PE-conjugated Antibody
By Anonymous on 08/15/2017
Application: Flow Sample Tested: Jurkat human acute T cell leukemia cell line Species: Human

Cell surface receptor level quantification for further animal experiment

Flow Cytometry Human CXCR4 PE-conjugated Antibody FAB170P
Human CXCR4 PE-conjugated Antibody
By Anonymous on 06/13/2017
Application: Flow Sample Tested: Granta-519,HL-60 human acute promyelocytic leukemia cell line,KG-1 human acute myelogenous leukemia cell line,Molm13,Ramos human Burkitt's lymphoma cell line,RS4;11 Species: Human
Flow Cytometry Human CXCR4 PE-conjugated Antibody FAB170P