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Human ErbB2/Her2 Herstatin Isoform Antibody

Catalog #: MAB4360
11 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB4360
MAB4360-SP
Product Details
Citations (11)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human ErbB2/Her2 Herstatin Isoform Antibody Summary

Species Reactivity
Human
Specificity
Detects human ErbB2/Her2 Herstatin Isoform in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) EGF R or rhErbB3 is observed.
Source
Monoclonal Mouse IgG2B Clone # 416727
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human ErbB2/Her2 Herstatin Isoform
Thr23-Gly419
Accession # AAD56009
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Herstatin

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ErbB2/Her2

Herstatin is a secreted 68 kDa glycoprotein encoded by an alternate transcript of the Her2/neu (ErbB2) gene containing the N-terminal 304 amino acids (aa) of subdomain I and II, and 79 intron-encoded aa at the C-terminus. It is an endogenous inhibitor of the EGF receptor family that disrupts receptor interactions and inhibits growth of tumor cells that overexpress Her2.

Long Name
Receptor Tyrosine Protein Kinase ErbB2
Entrez Gene IDs
2064 (Human); 13866 (Mouse); 24337 (Rat); 102146608 (Cynomolgus Monkey)
Alternate Names
CD340 antigen; CD340; c-erb B2/neu protein; EC 2.7.10; EGFR2; ErbB2; HER2; HER-2; HER2EC 2.7.10.1; herstatin; Metastatic lymph node gene 19 protein; MLN 19; MLN19; Neu Oncogene; NEUHER-2/neu; neuroblastoma/glioblastoma derived oncogene homolog; NGL; NGLTKR1; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)

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Citations for Human ErbB2/Her2 Herstatin Isoform Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

11 Citations: Showing 1 - 10
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  1. iPSC-derived beta cells model diabetes due to glucokinase deficiency.
    Authors: Hua H, Shang L, Martinez H et al.
    J Clin Invest
  2. Mixed-Lineage Leukemia 1 Inhibition Enhances the Differentiation Potential of Bovine Embryonic Stem Cells by Increasing H3K4 Mono-Methylation at Active Promoters
    Authors: Li, C;Han, X;Wang, J;Liu, F;Zhang, Y;Li, Z;Lu, Z;Yue, Y;Xiang, J;Li, X;
    International journal of molecular sciences
  3. Variation in TAF1 expression in female carrier induced pluripotent stem cells and human brain ontogeny has implications for adult neostriatum vulnerability in X-linked Dystonia Parkinsonism
    Authors: Laura D'Ignazio, Ricardo S. Jacomini, Bareera Qamar, Kynon J. M. Benjamin, Ria Arora, Tomoyo Sawada et al.
    eNeuro
  4. Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease
    Authors: Mi-Young Son, Mi-Ok Lee, Hyejin Jeon, Binna Seol, Jung Hwa Kim, Jae-Suk Chang et al.
    Experimental & Molecular Medicine
  5. An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils
    Authors: Huan-Ting Lin, Hideki Masaki, Tomoyuki Yamaguchi, Taizo Wada, Akihiro Yachie, Ken Nishimura et al.
    Molecular Therapy - Methods & Clinical Development
  6. Derivation of induced pluripotent stem cells from orangutan skin fibroblasts
    Authors: Krishna Ramaswamy, Wing Yan Yik, Xiao-Ming Wang, Erin N. Oliphant, Wange Lu, Darryl Shibata et al.
    BMC Research Notes
  7. Reduced PLP1 expression in induced pluripotent stem cells derived from a Pelizaeus–Merzbacher disease patient with a partial PLP1 duplication
    Authors: Keiko Shimojima, Takahito Inoue, Yuki Imai, Yasuhiro Arai, Yuta Komoike, Midori Sugawara et al.
    Journal of Human Genetics
  8. Comprehensive comparison of Pacific Biosciences and Oxford Nanopore Technologies and their applications to transcriptome analysis
    Authors: JL Weirather, M de Cesare, Y Wang, P Piazza, V Sebastiano, XJ Wang, D Buck, KF Au
    F1000Res, 2017-02-03;6(0):100.
  9. Reconstruction of Alzheimer's Disease Cell Model In Vitro via Extracted Peripheral Blood Molecular Cells from a Sporadic Patient
    Authors: S Liu, Y Zhao, X Su, C Zhou, P Yang, Q Lin, S Li, H Tan, Q Wang, C Wang, Q Wu
    Stem Cells International, 2020-12-18;2020(0):8897494.
  10. Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state
    Authors: H Ozaki, H Suga, M Sakakibara, M Soen, N Miyake, T Miwata, S Taga, T Nagai, M Kano, K Mitsumoto, T Miyata, T Kobayashi, M Sugiyama, T Onoue, H Takagi, D Hagiwara, S Iwama, R Banno, G Iguchi, Y Takahashi, K Muguruma, H Inoue, H Arima
    Scientific Reports, 2022-10-17;12(1):17381.
  11. Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells
    Authors: AR Nickolls, MM Lee, DF Espinoza, M Szczot, RM Lam, Q Wang, J Beers, J Zou, MQ Nguyen, HJ Solinski, AA AlJanahi, KR Johnson, ME Ward, AT Chesler, CG Bönnemann
    Cell Rep, 2020-01-21;30(3):932-946.e7.

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