Does this Biosimilar antibody have the same sequence as the therapeutic antibody?

The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody, except for Catalog numbers MAB9677, MAB9575, MAB9577, MAB9589, and their conjugates. These four antibodies have the same variable region as the Biosimilar, but not the same constant region.

What is a Biosimilar antibody?

A Biosimilar antibody is a non-therpeutic, recombinantly-expressed antibody which has the same sequence as the corresponding therapeutic antibody. It is for research use only. The nomenclature of the Biosimilar antibody includes the name of the therapeutic antibody. For example, Catalog # MAB9577 is called Human EGFR (Research Grade CetuxiMab Biosimilar) antibody.

Human IGF-I R/IGF1R (Research Grade Teprotumumab Biosimilar) Antibody

Name: Human IGF-I R/IGF1R (Research Grade Teprotumumab Biosimilar) Antibody
Brand: R&D Systems
SKU: MAB9718

Catalog #: MAB9718
1 Citation Datasheet / COA / SDS

Recombinant Monoclonal Antibody For Research Use Only

Discontinued Product

MAB9718 has been discontinued.

View all IGF-I R/IGF1R products.

Detection of IGF-I R/IGF1R in MCF-7 Human Cell Line by Flow Cytometry.

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All IGF-I R/IGF1R Antibodies

Product Details

Citations (1)

FAQs

Reviews

Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IGF-I R/IGF1R (Research Grade Teprotumumab Biosimilar) Antibody Summary

Species Reactivity

Human

Specificity

Detects human IGF-I R/IGF1R based on Teprotumumab therapeutic antibody. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Teprotumumab. This product is for research use only.

Source

Recombinant Monoclonal Human IgG₁ Clone # Hu14

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Human IGF-I R/IGF1R

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Endotoxin Level

<0.10 EU per 1 μg of the antibody by the LAL method.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25 µg/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of IGF-I R/IGF1R in MCF-7 Human Cell Line by Flow Cytometry. MCF-7 human cell line was stained with Human Anti-Human IGF-I R/IGF1R (Research Grade Teprotumumab Biosimilar) Monoclonal Antibody (Catalog # MAB9718, filled histogram) or irrelevant antibody (open histogram) followed by APC-conjugated Anti-Human IgG Secondary Antibody (Catalog # F0135). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IGF-I R/IGF1R

Teprotumumab is a biosimilar directed against the extracellular domain of IGF-I R/IGF1R. This product constitutes the immunogen used for the anti-Idiotype catalog number MAB9634.

Long Name

Insulin-like Growth Factor I Receptor

Entrez Gene IDs

3480 (Human)

Alternate Names

CD221 antigen; CD221; EC 2.7.10; EC 2.7.10.1; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGF-IR; IGFR; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; JTK13; MGC142170; MGC142172; MGC18216; soluble IGF1R variant 1; soluble IGF1R variant 2

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citation for Human IGF-I R/IGF1R (Research Grade Teprotumumab Biosimilar) Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

Intrathecal injection of scAAV9-hIGF1 prolongs the survival of ALS model mice by inhibiting the NF-kB pathway
Authors: H Hu, H Lin, W Duan, C Cui, Z Li, Y Liu, W Wang, D Wen, Y Wang, C Li
Neuroscience, 2018-02-12;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: IHC

FAQs

Does this Biosimilar antibody have the same sequence as the therapeutic antibody?
- The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody, except for Catalog numbers MAB9677, MAB9575, MAB9577, MAB9589, and their conjugates. These four antibodies have the same variable region as the Biosimilar, but not the same constant region.
What is a Biosimilar antibody?
- A Biosimilar antibody is a non-therpeutic, recombinantly-expressed antibody which has the same sequence as the corresponding therapeutic antibody. It is for research use only. The nomenclature of the Biosimilar antibody includes the name of the therapeutic antibody. For example, Catalog # MAB9577 is called Human EGFR (Research Grade CetuxiMab Biosimilar) antibody.

View all Antibody FAQs