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Human LAIR1 PE-conjugated Antibody

Catalog #: FAB2664P
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB2664P
Detection of LAIR1 in Human Lymphocytes by Flow Cytometry.
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Product Details
Citations (4)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human LAIR1 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human LAIR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human LAIR2 or recombinant mouse LAIR1 is observed.
Source
Monoclonal Mouse IgG2B Clone # 342219
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human LAIR1 isoform 1
Gln22-His163
Accession # Q6GTX8
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of LAIR1 antibody in Human Lymphocytes antibody by Flow Cytometry. View Larger

Detection of LAIR1 in Human Lymphocytes by Flow Cytometry. Human lymphocytes were stained with Mouse Anti-Human LAIR1 PE-conjugated Monoclonal Antibody (Catalog # FAB2664P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: LAIR1

Leukocyte-associated Ig-like receptor-1 (LAIR1; also CD305) is a 46 kDa inhibitory receptor belonging to the Ig superfamily. It is a type I transmembrane protein with one extracellular Ig-like domain and two cytoplasmic ITIMs. Four LAIR-1 splice variants exist. LAIR1b has a 17 aa deletion outside the Ig loop in the extracellular domain. It differs from LAIR1c by one aa residue. LAIR1d has a 77 aa truncation in the cytoplasmic domain. LAIR1 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells and most thymocytes. The extracellular domain of human LAIR1 shares 40% aa identity with that of the mouse protein.

Long Name
Leukocyte-associated Ig-like Receptor 1
Entrez Gene IDs
3903 (Human); 52855 (Mouse); 574531 (Rat); 102136964 (Cynomolgus Monkey)
Alternate Names
CD305 antigen; CD305; CD305leukocyte-associated Ig-like receptor 1; HLAIR1; LAIR1; LAIR-1; leukocyte-associated immunoglobulin-like receptor 1

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Citations for Human LAIR1 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.
    Authors: Ramos-Amaya A, Rodriguez-Bayona B, Lopez-Blanco R, Andujar E, Perez-Alegre M, Campos-Caro A, Brieva J
    J Immunol, 2014-12-29;194(3):1031-8.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Flow Cytometry
  2. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors.
    J. Clin. Invest., 2012-03-12;122(4):1487-502.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry.
    Authors: Llinas L, Lazaro A, de Salort J, Matesanz-Isabel J, Sintes J, Engel P
    Immunol. Lett., 2010-10-15;134(2):113-21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Differential expression of SLAMS and other modulatory molecules by human plasma cells during normal maturation.
    Authors: Rodriguez-Bayona B, Ramos-Amaya A, Brieva JA
    Immunol. Lett., 2010-10-13;134(2):122-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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