Human LILRB4/CD85k/ILT3 Biotinylated Antibody Summary
Pro17-His257
Accession # ABM86208
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human ILT3/CD85k/LILRB4 by Flow Cytometry CSF monocytes express high levels of ILT3.(A) Paired blood and CSF samples were analyzed for expression of ILT3 on CD14+ monocytes by flow cytometry. The specific fluorescent index is shown. Patients were categorized according to their diagnosis as having non-inflammatory neurological diseases (NIND, n = 14; marked by dot) or inflammatory neurological disease (IND, n = 8) including 5 MS patients (marked by x) and 3 patients with other inflammatory neurological disease (diamond). A Mann-Whitney U test was performed to assess statistical significance. (B) Histogram of a representative staining in a patient with NIND. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25551576), licensed under a CC-BY license. Not internally tested by R&D Systems.
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Detection of Human ILT3/CD85k/LILRB4 by Flow Cytometry CSF monocytes express high levels of ILT3.(A) Paired blood and CSF samples were analyzed for expression of ILT3 on CD14+ monocytes by flow cytometry. The specific fluorescent index is shown. Patients were categorized according to their diagnosis as having non-inflammatory neurological diseases (NIND, n = 14; marked by dot) or inflammatory neurological disease (IND, n = 8) including 5 MS patients (marked by x) and 3 patients with other inflammatory neurological disease (diamond). A Mann-Whitney U test was performed to assess statistical significance. (B) Histogram of a representative staining in a patient with NIND. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25551576), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: LILRB4/CD85k/ILT3
ILT3, also known as leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) and leukocyte immunoglobulin-like receptor 5 (LIR-5), is a type I membrane protein that functions as a receptor for class I MHC antigens. It contains cytoplasmic ITIM motifs and is involved in the down-regulation of immune responses.
Product Datasheets
Citations for Human LILRB4/CD85k/ILT3 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients.
Authors: Waschbisch A, Sanderson N, Krumbholz M, Vlad G, Theil D, Schwab S, Maurer M, Derfuss T
PLoS ONE, 2014-12-31;9(12):e115488.
Species: Human
Sample Types: Serum
Applications: ELISA Development (Detection) -
Cytokine induced expression of programmed death ligands in human neutrophils.
Authors: Bankey PE, Banerjee S, Zucchiatti A, De M, Sleem RW, Lin CF, Miller-Graziano CL, De AK
Immunol. Lett., 2010-02-01;129(2):100-7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
Authors: Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T
J. Immunol., 2008-10-01;181(7):4742-51.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients.
Authors: Suciu-Foca N, Feirt N, Zhang QY, Vlad G, Liu Z, Lin H, Chang CC, Ho EK, Colovai AI, Kaufman H, D'Agati VD, Thaker HM, Remotti H, Galluzzo S, Cinti P, Rabitti C, Allendorf J, Chabot J, Caricato M, Coppola R, Berloco P, Cortesini R
J. Immunol., 2007-06-01;178(11):7432-41.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
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