Human LRRN1/NLRR-1 Biotinylated Antibody

Catalog #: BAF4990 Datasheet / COA / SDS

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BAF4990

All LRRN1/NLRR-1 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human LRRN1/NLRR-1 Biotinylated Antibody Summary

Species Reactivity

Human

Specificity

Detects human LRRN1/NLRR‑1 in Western blots. In Western blots, approximately 5% cross-reactivity with recombinant human NLRR-3 is observed.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human LRRN1/NLRR‑1
Ser26-Ala631
Accession # AAH34947

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human LRRN1/NLRR‑1

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: LRRN1/NLRR-1

LRRN1 (Leucine-rich repeat neuronal protein 1; NLRR1) is a 95 kDa member of the neuronal LRR family of proteins. It is a cell-surface glycoprotein that is expressed on embryonic motor neurons and somatic myoblasts. Human LRRN1 is 716 amino acids (aa) in length. It is a type I transmembrane protein that contains a 606 aa extracellular region (aa 26-631) and a short 64 aa cytoplasmic tail. The extracellular region shows eleven LRRs (aa 94-384) that mediate protein-protein interactions, one C2-type Ig-like domain and one fibronectin type III domain. There is one potential alternate start site at Met286. Over aa 26-631, human LRRN1 shares 96% aa sequence identity with mouse LRRN1.

Long Name

Leucine-rich Repeat Neuronal 1

Entrez Gene IDs

57633 (Human); 16979 (Mouse); 500280 (Rat)

Alternate Names

fibronectin type III, immunoglobulin and leucine rich repeat domains 3; FIGLER3; KIAA1497; leucine rich repeat neuronal 1; leucine-rich repeat neuronal protein 1; LRN; LRRN1; Neuronal leucine-rich repeat protein 1; NLRR1; NLRR-1