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Human Mer APC-conjugated Antibody

Catalog #: FAB8912A
11 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB8912A
Detection of Mer in HepG2 Human Cell Line by Flow Cytometry.
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Product Details
Citations (11)
FAQs
Supplemental Products
Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Mer APC-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Mer in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) Axl, rhDtk, or recombinant mouse Mer is observed.
Source
Monoclonal Mouse IgG2B Clone # 125518
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Mer
Met1-Ala499
Accession # AAB60430
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of Mer antibody in HepG2 Human Cell Line antibody by Flow Cytometry. View Larger

Detection of Mer in HepG2 Human Cell Line by Flow Cytometry. HepG2 human hepatocellular carcinoma cell line was stained with Mouse Anti-Human Mer APC-conjugated Monoclonal Antibody (Catalog # FAB8912A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry Detection of Mer antibody in U937 Human Cell Line antibody by Flow Cytometry. View Larger

Detection of Mer in U937 Human Cell Line by Flow Cytometry. U937 human histiocytic lymphoma cell line was stained with Mouse Anti-Human Mer APC-conjugated Monoclonal Antibody (Catalog # FAB8912A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Mer

Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions.

References
  1. Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
  2. Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
Long Name
Receptor Tyrosine Protein Kinase Mer
Entrez Gene IDs
10461 (Human); 17289 (Mouse); 102143798 (Cynomolgus Monkey)
Alternate Names
c-Eyk; c-mer proto-oncogene tyrosine kinase; C-mer; EC 2.7.10; EC 2.7.10.1; MER receptor tyrosine kinase; Mer; MerTK; MGC133349; Receptor tyrosine kinase MerTK; RP38Proto-oncogene c-Mer; STK kinase; tyrosine-protein kinase Mer

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Citations for Human Mer APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

11 Citations: Showing 1 - 10
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  1. Regulation of Mertk Surface Expression via ADAM17 and ?-Secretase Proteolytic Processing
    Authors: Lahey, KC;Varsanyi, C;Wang, Z;Aquib, A;Gadiyar, V;Rodrigues, AA;Pulica, R;Desind, S;Davra, V;Calianese, DC;Liu, D;Cho, JH;Kotenko, SV;De Lorenzo, MS;Birge, RB;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells
    Authors: Oltin-Tiberiu Pop, Anne Geng, Emilio Flint, Arjuna Singanayagam, Caner Ercan, Lucia Possamai et al.
    Cellular and Molecular Gastroenterology and Hepatology
  3. Anti-inflammatory clearance of amyloid-beta by a chimeric Gas6 fusion protein
    Authors: H Jung, SY Lee, S Lim, HR Choi, Y Choi, M Kim, S Kim, Y Lee, KH Han, WS Chung, CH Kim
    Nature Medicine, 2022-08-04;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causes
    Authors: FM Trovato, S Mujib, E Jerome, A Cavazza, P Morgan, J Smith, MT Depante, K O'Reilly, J Luxton, T Mare, S Napoli, MJ McPhail
    Heliyon, 2022-06-24;8(6):e09733.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Cladribine Treatment for MS Preserves the Differentiative Capacity of Subsequently Generated Monocytes, Whereas Its Administration In Vitro Acutely Influences Monocyte Differentiation but Not Microglial Activation
    Authors: Tiago Medeiros-Furquim, Sinan Ayoub, Laura J. Johnson, Andrea Aprico, Eze Nwoke, Michele D. Binder et al.
    Frontiers in Immunology
  6. A Heterotypic Tridimensional Model to Study the Interaction of Macrophages and Glioblastoma In Vitro
    Authors: MJ Gattas, IG Estecho, MA Lago Huvel, AE Errasti, EA Carrera Si, M Simian
    International Journal of Molecular Sciences, 2021-05-12;22(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR
    Authors: W Nowak, LN Grendas, LM Sanmarco, IG Estecho, ÁR Arena, N Eberhardt, DE Rodante, MP Aoki, FM Daray, EA Carrera Si, AE Errasti
    EBioMedicine, 2019-11-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  8. Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice
    Authors: A Carestia, HA Mena, CM Olexen, JM Ortiz Wilc, S Negrotto, AE Errasti, RM Gómez, CN Jenne, EA Carrera Si, M Schattner
    Cell Rep, 2019-07-23;28(4):896-908.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors
    Authors: FJ Zapatero-B, E Dietzel, O Dolnik, K Döhner, R Costa, B Hertel, B Veselkova, J Kirui, A Klintworth, MP Manns, S Pöhlmann, T Pietschman, T Krey, S Ciesek, G Gerold, B Sodeik, S Becker, T von Hahn
    Viruses, 2019-03-19;11(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
    Authors: E Triantafyl, OT Pop, LA Possamai, A Wilhelm, E Liaskou, A Singanayag, C Bernsmeier, W Khamri, G Petts, R Dargue, SP Davies, J Tickle, M Yuksel, VC Patel, RD Abeles, Z Stamataki, SM Curbishley, Y Ma, ID Wilson, M Coen, KJ Woollard, A Quaglia, J Wendon, MR Thursz, DH Adams, CJ Weston, CG Antoniades
    Gut, 2017-04-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages.
    Authors: Zheng S, Hedl M, Abraham C
    J Immunol, 2015-01-07;194(4):1928-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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Human Mer APC-conjugated Antibody
By Anonymous on 09/20/2018
Application: Flow Sample Tested: Peripheral blood monocytes,Peripheral blood mononuclear cells (PBMCs) Species: Human
Flow Cytometry Human Mer APC-conjugated Antibody FAB8912A