Human Mesothelin APC-conjugated Antibody Summary
Glu296-Gly580
Accession # AAH09272
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Mesothelin in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line was stained with Rat Anti-Human Mesothelin APC-conjugated Monoclonal Antibody (Catalog # FAB32652A, filled histogram) or isotype control antibody (Catalog # IC006A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Mesothelin
Mesothelin is a 40 kDa glycosylphosphatidylinositol-anchored glycoprotein that is expressed on mesothelial cells in the pleura, pericardium and peritoneum and overexpressed in mesotheliomas and ovarian or pancreatic adenocarcinoma. Mesothelin is a product of the CAK-1 gene, which also encodes Megakaryocyte-Potentiating Factor (MPF). Mature human Mesothelin shares 60% amino acid identity with either mouse or rat Mesothelin. Two variant forms exist; variant 1 has an eight amino acid (1 kDa) insertion and is rarely expressed, while variant 2 is a truncated form secreted in the majority of ovarian cancers but rarely found in normal individuals.
Product Datasheets
Citations for Human Mesothelin APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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Unlocking the potential of allogeneic V?2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering
Authors: Lee, D;Dunn, ZS;Guo, W;Rosenthal, CJ;Penn, NE;Yu, Y;Zhou, K;Li, Z;Ma, F;Li, M;Song, TC;Cen, X;Li, YR;Zhou, JJ;Pellegrini, M;Wang, P;Yang, L;
Nature communications
Species: Human
Sample Types:
Applications: Flow Cytometry -
Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality
Authors: Esther Schoutrop, Stefanie Renken, Isabella Micallef Nilsson, Paula Hahn, Thomas Poiret, Rolf Kiessling et al.
OncoImmunology
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Prostacyclin Released by Cancer-Associated Fibroblasts Promotes Immunosuppressive and Pro-Metastatic Macrophage Polarization in the Ovarian Cancer Microenvironment
Authors: L Sommerfeld, I Knuth, F Finkernage, J Pesek, WA Nockher, JM Jansen, U Wagner, A Nist, T Stiewe, S Müller-Brü, R Müller, S Reinartz
Cancers, 2022-12-13;14(24):.
Species: Human
Sample Types: Whole Cell
Applications: Flow Cytometry -
Mesothelin‑targeted second generation CAR‑T cells inhibit growth of mesothelin‑expressing tumors in�vivo
Authors: Lin Ye, Yuqing Lou, Liming Lu, Xiaohong Fan
Experimental and Therapeutic Medicine
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An in vivo platform for tumor biomarker assessment.
Authors: Servais EL, Suzuki K, Colovos C
PLoS ONE, 2011-10-26;6(10):e26722.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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The antibody epitope is sensitive to enzymatic cleavage and this is not included in the spec sheet. Staining is completely prevented by Trypsin or Accutase.
