Human MMP-10 Antibody Summary
Tyr18-Cys476
Accession # P09238
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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MMP‑10 in Human Colon Cancer Tissue. MMP‑10 was detected in immersion fixed paraffin-embedded sections of human colon cancer using Human MMP‑10 Monoclonal Antibody (Catalog # MAB910) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MMP-10
Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-10 (stromelysin 2) degrades a broad range of substrates including gelatin, collagen types III, IV and V, fibronectin, aggrecan, and pig cartilage proteoglycan. MMP-10 can activate other MMPs such as MMP-1 and MMP-8. MMP-10 is expressed in keratinocytes, T cells, menstrual endometrium, and a few tumor samples. Structurally, MMP-10 may be divided into four distinct domains: a pro-domain which is cleaved upon activation, a catalytic domain containing the zinc binding site; a short linker region, and a carboxyl terminal hemopexin-like domain.
Product Datasheets
Citations for Human MMP-10 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
9
Citations: Showing 1 - 9
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Human apical-out nasal organoids reveal an essential role of matrix metalloproteinases in airway epithelial differentiation
Authors: Li, L;Jiao, L;Feng, D;Yuan, Y;Yang, X;Li, J;Jiang, D;Chen, H;Meng, Q;Chen, R;Fang, B;Zou, X;Luo, Z;Ye, X;Hong, Y;Liu, C;Li, C;
Nature communications
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma
Authors: J Kudelski, G M?ynarczyk, M Gudowska-S, B Mroczko, B Darewicz, M Bruczko-Go, L Romanowicz
International Journal of Environmental Research and Public Health, 2022-10-02;19(19):.
Species: Human
Sample Types: Tissue Homogenates
Applications: Western Blot -
Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma
Authors: J Kudelski, G M?ynarczyk, M Gudowska-S, B Mroczko, B Darewicz, M Bruczko-Go, K Sobolewski, L Romanowicz
Journal of Clinical Medicine, 2021-08-19;10(16):.
Species: Human
Sample Types: Tissue Homogenates
Applications: Western Blot -
Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis
Authors: Jameson T. Crowley, Klemen Strle, Elise E. Drouin, Annalisa Pianta, Sheila L. Arvikar, Qi Wang et al.
Journal of Autoimmunity
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MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer.
Authors: Du X, Lin B, Wang Q, Li H, Ingalla E, Tien J, Rooney I, Ashkenazi A, Penuel E, Qing J
Clin Cancer Res, 2014-10-17;20(24):6324-35.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Matrix metalloproteinase activity in pediatric acute lung injury.
Authors: Kong MY, Gaggar A, Li Y
Int J Med Sci, 2008-12-16;6(1):9-17.
Species: Human
Sample Types: Tissue Secretion
Applications: Western Blot -
AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor.
Authors: Schnickmann S, Camacho-Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, Szabowski A, Breuhahn K
J. Invest. Dermatol., 2008-11-20;129(5):1140-8.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
Authors: Puram Sidharth V, Tirosh Itay, Parikh Anuraag S et al.
Cell
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Modulation of proteoglycan receptor PTP? enhances MMP-2 activity to promote recovery from multiple sclerosis
Authors: F Luo, AP Tran, L Xin, C Sanapala, BT Lang, J Silver, Y Yang
Nat Commun, 2018-10-08;9(1):4126.
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I checked it on human lung sample and it did not work. I used it with no retrieval, citrate retrieval and EDTA retrieval. All did not work. Technical Service will be following up with this customer.
