Human/Mouse LRRN1/NLRR-1 Antibody Summary
Ser26-Ala631
Accession # AAH34947
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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LRRN1/NLRR‑1 in Embryonic Mouse Somites. LRRN1/NLRR-1 was detected in immersion fixed frozen sections of embryonic mouse somites (E9.5) using 10 µg/mL Sheep Anti-Human LRRN1/NLRR-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4990) overnight at 4 °C. Tissue was stained with the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # NL010) and counterstained with DAPI (blue). View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: LRRN1/NLRR-1
LRRN1 (Leucine-rich repeat neuronal protein 1; NLRR1) is a 95 kDa member of the neuronal LRR family of proteins. It is a cell-surface glycoprotein that is expressed on embryonic motor neurons and somatic myoblasts. Human LRRN1 is 716 amino acids (aa) in length. It is a type I transmembrane protein that contains a 606 aa extracellular region (aa 26-631) and a short 64 aa cytoplasmic tail. The extracellular region shows eleven LRRs (aa 94-384) that mediate protein-protein interactions, one C2-type Ig-like domain and one fibronectin type III domain. There is one potential alternate start site at Met286. Over aa 26-631, human LRRN1 shares 96% aa sequence identity with mouse LRRN1.
Product Datasheets
Citations for Human/Mouse LRRN1/NLRR-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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NLRR1 Is a Potential Therapeutic Target in Neuroblastoma and MYCN-Driven Malignant Cancers
Authors: Atsushi Takatori, MD. Shamim Hossain, Atsushi Ogura, Jesmin Akter, Yohko Nakamura, Akira Nakagawara
Frontiers in Oncology
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Leucine-rich repeat neuronal protein-1 suppresses apoptosis of gastric cancer cells through regulation of Fas/FasL
Authors: B Liu, Y Zhang, Y Fan, S Wang, Z Li, M Deng, C Li, J Wang, R Ma, X Wang, Y Wang, L Xu, K Hou, X Che, Y Liu, X Qu
Cancer Sci., 2019-06-10;110(7):2145-2155.
Species: Human, Xenograft
Sample Types: Cell Lysates, Whole Tissue
Applications: IHC, Western Blot -
Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity
Authors: M Baek, V Menon, TM Jessell, AW Hantman, JS Dasen
Cell Rep, 2019-05-28;27(9):2620-2635.e4.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma
Sci Rep, 2016-09-08;6(0):32682.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P, Immunoprecipitation
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