Human/Mouse MEF2C Antibody Summary
Ala135-Lys239
Accession # Q06413
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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MEF2C in C2C12 Mouse Cell Line. MEF2C was detected in immersion fixed differentiated C2C12 mouse myoblast cell line using Mouse Anti-Human/Mouse MEF2C Monoclonal Antibody (Catalog # MAB6786) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counter-stained with DAPI (blue). Specific staining was localized to nucleus of myoblasts. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
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MEF2C in Human Brain. MEF2C was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Mouse Anti-Human/Mouse MEF2C Monoclonal Antibody (Catalog # MAB6786) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal nuclei. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MEF2C
MEF2C (myocyte enhancer factor-2C) is a 51 kDa (predicted) protein that is one of four members of the MEF2/MADS (MCM1, Agamous, Deficiens, Serum response) box family of transcription factors. The 473 amino acid (aa) human MEF2C contains a MADS box for dimerization (aa 3-57), a DNA binding domain (aa 58-86), a beta domain (aa 271-278; missing in a 465 aa isoform), a transcriptional repressor (aa 368-399; missing in a 441 aa isoform) and several acetylation and ser/thr phosphorylation sites. Within aa 135-239, human MEF2C shares 95% and 98% aa identity with mouse and rat MEF2C, respectively. MEF2C plays important roles in preferential lymphoid differentiation of hematopoietic precursors, and in neuronal, cardiac and skeletal muscle morphogenesis.
Product Datasheets
Citations for Human/Mouse MEF2C Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience
Authors: JC Udeochu, S Amin, Y Huang, L Fan, ERS Torres, GK Carling, B Liu, H McGurran, G Coronas-Sa, G Kauwe, GA Mousa, MY Wong, P Ye, RK Nagiri, I Lo, J Holtzman, C Corona, A Yarahmady, MT Gill, RM Raju, SA Mok, S Gong, W Luo, M Zhao, TE Tracy, RR Ratan, LH Tsai, SC Sinha, L Gan
Nature Neuroscience, 2023-04-24;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration
Authors: Scarlett J. Barker, Ravikiran M. Raju, Noah E.P. Milman, Jose Davila-Velderrain, Fatima Davila-Velderrain, Fatima Gunter-Rahman et al.
Science Translational Medicine
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Orai1 inhibitor STIM2 beta regulates myogenesis by controlling SOCE dependent transcriptional factors
Authors: Kyu Min Kim, Anshul Rana, Chan Young Park
Scientific Reports
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Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma
