Human PDGF R beta Biotinylated Antibody Summary
Leu33-Phe530 (Glu241Asp)
Accession # P09619
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: PDGF R beta
PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF‑BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF‑BB only with high-affinity. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and hetero-dimerization and signal transduction. The expression of the alpha and beta receptors is independently regulated in various cell types. Recombinant soluble PDGF R beta binds PDGF with high affinity and is potent PDGF antagonist.
- Heldin, C.H. and L. Claesson-Welsh (1994) in Guidebook to Cytokines and Their Receptors, Nicola, N.A. ed. Oxford University Press, New York, p. 202.
Product Datasheets
Citations for Human PDGF R beta Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline
Authors: A Montagne, DA Nation, AP Sagare, G Barisano, MD Sweeney, A Chakhoyan, M Pachicano, E Joe, AR Nelson, LM D'Orazio, DP Buennagel, MG Harrington, TLS Benzinger, AM Fagan, JM Ringman, LS Schneider, JC Morris, EM Reiman, RJ Caselli, HC Chui, J Tcw, Y Chen, J Pa, PS Conti, M Law, AW Toga, BV Zlokovic
Nature, 2020-04-29;581(7806):71-76.
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A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid
Authors: Melanie D. Sweeney, Abhay P. Sagare, Maricarmen Pachicano, Michael G. Harrington, Elizabeth Joe, Helena C. Chui et al.
Alzheimer's & Dementia
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Isolation of Stem Cells, Endothelial Cells and Pericytes from Human Infantile Hemangioma
Authors: Lan Huang, Joyce Bischoff
BIO-PROTOCOL
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Vascular endothelial growth factor signals through platelet-derived growth factor receptor beta in meningiomas in vitro.
Br. J. Cancer, 2012-10-09;107(10):1702-13.
Species: Human
Sample Types: Cell Lysates
Applications: TaqMan Protein Assay
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