Human RNF43 (NP_060233) VersaClone cDNA

Catalog #: RDC0503 Datasheet / COA / SDS

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RDC0503

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Human RNF43 (NP_060233) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: RNF43

RNF43 (RING finger protein 43) is an E3 ubiquitin ligase that may be expressed on the plasma membrane or intracellularly. It can associate with the nuclear matrix protein HAP95/AKAP8L, the ubiquitin ligase NEDL1, and p53. It also interacts with the cell surface ubiquitin ligase ZNRF3, and both RNF43 and ZNRF3 antagonize Wnt signaling by promoting the turnover of Frizzled receptors. Interaction with the R-Spondin Wnt-regulating proteins can also antagonize ZNRF3. RNF43 is frequently overexpressed in cancers, correlating with growth-promoting activity and colorectal and hepatocellular cancer pathogenesis. It is expressed in intestinal epithelial stem cells in colon crypts, where it limits the ability of Wnts to induce proliferation.

Long Name

Ring Finger Protein 43

Entrez Gene IDs

54894 (Human); 207742 (Mouse); 303412 (Rat)

Alternate Names

DKFZp781H02126; DKFZp781H0392; FLJ20315; FLJ77466; FLJ99338; MGC125630; ring finger protein 43; RNF124; RNF43; URCC

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