Human STYK1 PE-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: STYK1

STYK1 (Ser/Thr/Tyr kinase 1) also known as Novel Oncogene with Kinase-domain (NOK), is a 46-50 kDa, member of the FGFR/PDGFR  (or RPTK-like) family of tyrosine kinases.  It appears to be a transmembrane (TM) component of early endosomes, and likely participates in the trafficking of cell membrane receptors such as the EGFR. STYK1 appears to form multimers, a process regulated by its TM domain. Cells recognized to express STYK1 are principally tumor cellls, as normal cell expression seems to be restricted, and shows little correlation between mice and human. Both MAPK and PI3K pathways are activated by STYK1 activity, and STYK1 is associated with oncogenesis.  Human STYK1 is 422 amino acids (aa) in length.  It contains 25 aa N-terminus, a 21 aa putative transmembrane segment, and a 396 aa C-terminus that contains a Tyr-kinase domain (aa 118-372).  Over aa 72-320, human STYK1 is 77% and 83% identical to mouse and canine STYK1, respectively.  

Product Datasheets

Related Research Areas

• Cancer Biomarkers
• Receptor Tyrosine Kinases (RTKs)
• Receptor Tyrosine Kinases (RTKs) in the Akt Pathway