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Human TEM8/ANTXR1 Antibody

Catalog #: MAB3886 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB3886
MAB3886-SP
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human TEM8/ANTXR1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human TEM8/ANTXR1 in direct ELISAs and Western blots.
Source
Monoclonal Mouse IgG2B Clone # 371113
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human TEM8/ANTXR1 isoform 1
Gln28-Gly320
Accession # Q9H6X2
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human TEM8/ANTXR1

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TEM8/ANTXR1

Tumor Endothelial Marker 8 (TEM8), also called ATR1 and ANTXR1, is a glycoprotein of the anthrax toxin receptor family that is expressed by endothelial cells. Type I transmembrane isoforms of 564 aa (80‑85 kDa) and 368 aa (60 kDa) and potentially secreted isoforms of 330 aa and 297 aa (45 kDa) are differentially expressed. All diverge at the C-terminal end but share the N-terminal vWFA domain that binds the anthrax toxin PA subunit as well as collagens I and IV. Human TEM8 shares 99% aa identity with mouse and rat and 92% identity with dog and chick TEM8 within the extracellular domain.

Long Name
Tumor Endothelial Marker 8/Anthrax Toxin Receptor 1
Entrez Gene IDs
84168 (Human); 69538 (Mouse); 362393 (Rat)
Alternate Names
anthrax toxin receptor 1; ANTXR1; ATR2310008J16Rik; FLJ10601; FLJ11298; FLJ21776; TEM8; TEM82810405N18Rik; Tumor endothelial marker 8

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