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K34c

Catalog #: 5114 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5114/5
K34c | CAS No. 939769-93-4 | Integrin Receptor Inhibitors
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Description: Potent and selective α5β1 integrin inhibitor

Chemical Name: N-(2,6-Dimethylbenzoyl)-O-[3-(2-pyridinylamino)propyl]-L-tyrosine

Purity: ≥98%

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Biological Activity

K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide (Cat. No. 2706) or Ellipticine (Cat. No. 3357) and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin.

Technical Data

M.Wt:
447.53
Formula:
C26H29N3O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
939769-93-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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