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Kisspeptin 10 (human)

Catalog #: 2570
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2570/1
Kisspeptin 10 (human)
1 Image
Description: Endogenous ligand for kisspeptin receptor
Alternative Names: Metastin (45-54),Kp-10

Purity: ≥95%

Product Details
Citations (5)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Kisspeptin 10 (human) is a potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.

Analog also available.

Technical Data

M.Wt:
1302.45
Formula:
C63H83N17O14
Sequence:
YNWNSFGLRF

(Modification: Phe-10 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
374675-21-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
    Kotani et al.
    J.Biol.Chem., 2001;276:34631
  2. Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by OE.
    Peilecka-Fortuna et al.
    Endocrinology, 2007;149:1979
  3. Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors.
    Becker et al.
    Biochem.Biophys.Res.Comm., 2005;326:677

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Citations for Kisspeptin 10 (human)

The citations listed below are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:

5 Citations: Showing 1 - 5

  1. Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons.
    Authors: Constantin and Wray
    Endocrinology  2016;157:3197
  2. Differential stimulation of Ins secretion by GLP-1 and Kisspeptin-10.
    Authors: Schwetz Et al.
    PLoS One  2014;9:e113020
  3. Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer.
    Authors: Ji Et al.
    Autophagy  2014;14:723
  4. Kisspeptin-10 enhanced egg production in quails associated with the increase of triglyceride synthesis in liver.
    Authors: Wu Et al.
    Asian-Australas J Anim Sci  2013;26:1080
  5. Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes.
    Authors: Wu Et al.
    Asian-Australas J Anim Sci  2012;25:1229

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