Kynurenic acid

Catalog #: 0223
15 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0223/1G

Kynurenic acid | CAS No. 492-27-3 | iGluR Antagonists

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Description: Broad spectrum glutamatergic antagonist

Chemical Name: 4-Hydroxyquinoline-2-carboxylic acid

Purity: ≥98%

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Product Details

Citations (15)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Kynurenic acid is a broad spectrum EAA antagonist. Putative GPR35 ligand. Kynurenic acid protects tissues in cardiac, cerebral, renal, and retinal ischemia models via activation of GPR35 and induction of ATP synthase dimerization in an ATPIF1-dependent and pertussis toxin (Cat. No. 3097) sensitive manner.

Sodium Salt also available.

Technical Data

M.Wt:

189.17

Formula:

C₁₀H₇NO₃

Solubility:

Soluble to 50 mM in DMSO and to 100 mM in 1eq. NaOH

Purity:

≥98%

Storage:

Store at RT

CAS No:

492-27-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Sodium Salt Available

Background References

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35.
Wang J, Simonavicius N, Wu X et al.
J Biol Chem.
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Presynaptic calcium influx controls neurotransmitter release in part by regulating the effective size of the readily releasable pool.
Thanawala M, Regehr W
J Neurosci, 2013;33(11):4625-33.
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.
Perkins and Stone
Brain Res., 1982;247:184
NMDA receptors and ligands in the vertebrate CNS.
Stone and Burton
Prog.Neurobiol., 1988;30:333
The 'kynurenate test,' a biochemical assay for putative cognition enhancers.
Pittaluga et al.
J.Pharmacol.Exp.Ther., 1997;283:82

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Citations for Kynurenic acid

The citations listed below are publications that use Tocris products. Selected citations for Kynurenic acid include:

15 Citations: Showing 1 - 10

Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility.
Authors: Styr Et al.
Neuron 2019;102:1009
Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced mor. analgesia in a mouse neuropathic pain model.
Authors: Rojewska Et al.
Pharmacol Rep 2018;71:139
Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
Authors: Patel Et al.
Proc Natl Acad Sci U S A 2016;36:607
Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.
Authors: Weston Et al.
Front Mol Neurosci 2014;7:1
Perimenstrual-like hormonal regulation of extrasynaptic δ-containing GABAA receptors mediating tonic inhibition and neurosteroid sensitivity.
Authors: Carver Et al.
J Neurosci 2014;34:14181
Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis.
Authors: Wu Et al.
J Pharmacol Exp Ther 2013;346:146
The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
Authors: Chen Et al.
Neuron 2013;33:8336
On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
Authors: Gouet Et al.
PLoS One 2012;7:e49293
Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission.
Authors: Weston Et al.
J Neurosci 2012;32:11441
Suppression of PKR promotes network excitability and enhanced cognition by IF.-γ-mediated disinhibition.
Authors: Zhu Et al.
Cell 2011;147:1384

Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network.
Authors: Shinoda Et al.
Eur J Neurosci 2011;108:373

Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons.
Authors: Jones Et al.
Int J Neuropsychopharmacol 2011;105:1984

Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor.
Authors: Young and Neher
J Neurosci 2009;63:482

Two distinct types of inhibition mediated by cartwheel cells in the dorsal cochlear nucleus.
Authors: Mancilla
J Neurophysiol 2009;102:1287

Synaptic inputs to retinal ganglion cells that set the circadian clock.
Authors: Perez-Leon Et al.
J Neurophysiol 2006;24:1117

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