L-Quisqualic acid
Chemical Name: (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
Purity: ≥99%
Biological Activity
L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. L-Quisqualic acid sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Deleterious GRM1 mutations in schizophrenia.
Ayoub MA, Angelicheva D, Vile D
PLoS ONE, 2012;7(3):e32849. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.
Littman et al.
Neuropharmacology, 1995;34:829 -
Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Schulte et al.
Brain Res., 1994;649:203 -
Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Schulte et al.
Brain Res., 1994;649:203 -
(S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor.
Porter et al.
Br.J.Pharmacol., 1992;106:509
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Citations for L-Quisqualic acid
The citations listed below are publications that use Tocris products. Selected citations for L-Quisqualic acid include:
9 Citations: Showing 1 - 9
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Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo.
Authors: Shin Et al.
Oncogenesis 2018;7:86
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HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Authors: Scholler
Nat Chem Biol 2017;13(4):372
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Effects of acute and sustained administration of Vort. on the serotonin system in the hippocampus: electrophysiological studies in the rat brain.
Authors: Mansari Et al.
Psychopharmacology (Berl) 2015;232:2343
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The roads to mitochondrial dysfunction in a rat model of posttraumatic syringomyelia.
Authors: Hu and Tu
Biomed Res Int 2015;2015:831490
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Restoration of serotonin neuronal firing following long-term administration of bupr. but not parox. in olfactory bulbectomized rats.
Authors: Mansari Et al.
Int J Neuropsychopharmacol 2015;18
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Disruption of GRM1-mediated signalling using R.zole results in DNA damage in melanoma cells.
Authors: Wall Et al.
Pigment Cell Melanoma Res 2014;27:263
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Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
Authors: Porter Et al.
J Pharmacol Exp Ther 2005;315:711
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Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
Authors: Calò Et al.
J Neurosci 2005;25:2245
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Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.
Authors: Ferré Et al.
Proc Natl Acad Sci U S A 2002;99:11940
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