Lercanidipine hydrochloride
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride
Purity: ≥99%
Biological Activity
Lercanidipine hydrochloride is a L-type Ca2+ channel blocker that displays higher vascular selectivity than felodipine (Cat. No. 2960). Causes peripheral vasodilation with only weak negative inotropic activity. Antihypertensive. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 2.36 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Lercanidipine. A review of its efficacy in the management of hypertension.
Bang et al.
Drugs, 2003;63:2449 -
Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine lercanidipine.
Wirtz and Herzig
Br.J.Pharmacol., 2004;142:275 -
Antihypertensive effects of lercanidipine in experimental hypertensive rats and dogs.
Sironi et al.
Arzneim.Forsch., 1996;46:152
Product Datasheets
Citation for Lercanidipine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Lercanidipine hydrochloride include:
1 Citation: Showing 1 - 1
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Anti-inflammatoryactivity of calciumchannel blocker lercanidipine hydrochloride.
Authors: Vasigar
J Pharmacol Pharmacother 2013;4:238
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