Montelukast sodium
Discontinued Product
Chemical Name: 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt
Purity: ≥99%
Biological Activity
Montelukast sodium is a cysteinyl leukotriene receptor 1 (CysLT1) and GPR17 antagonist. Blocks pentylenetetrazole-induced seizures, blood brain barrier (BBB) disruption and leukocyte migration in mice. Reduces neuroinflammation, improves BBB integrity, enhances learning and memory, and restores hippocampal neurogenesis and cognitive function in aged rats. Orally active and brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.
Marschallinger et al.
Nat.Commun., 2015;6:8466 -
Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction.
Lenz et al.
Neuroscience, 2014;277:859
Product Datasheets
Citation for Montelukast sodium
The citations listed below are publications that use Tocris products. Selected citations for Montelukast sodium include:
1 Citation: Showing 1 - 1
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Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.
Authors: Wright Et al.
Biochem Biophys Res Commun 2019;520:35
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