Mouse CD200R1 Antibody Summary
Thr26-Pro238
Accession # BAE42266
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CD200R1
CD200 R1, also known as OX-2 receptor, is a 90 kDa, type I transmembrane protein that belongs to the immunoglobulin superfamily. CD200 R1 is important in the regulation of myeloid cell activity (1‑3). The mouse CD200 R1 cDNA encodes a 326 aa precursor that includes a 25 aa signal sequence, a 213 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 67 aa cytoplasmic domain. The ECD is composed of one Ig-like V-type domain and one Ig-like C2-type domain (4). Within the ECD, mouse CD200 R1 shares 56% and 70% aa sequence identity with human and rat CD200 R1, respectively. The ECD of mouse CD200 R1 shares 69%, 38%, 79%, and 83% aa sequence identity with the ECD of CD200 R2, 3, 4, and a CD200 R-like molecule, respectively. CD200 R1 is expressed primarily on mast cells, basophils, macrophages, and dendritic cells, (5‑7) while its ligand, CD200, is widely distributed (8). Disruption of this receptor-ligand pair by knockout of the CD200 gene leads to increased macrophage number and activation, plus a predisposition to autoimmune disorders (9). Association of CD200 with CD200 R1 takes place between their respective N-terminal Ig-like domains (10). The CD200 R-like molecules may interact differently with CD200 (11, 12). The cytoplasmic domain of CD200 R1 contains two non-ITIM tyrosine residues which are required for propagating its inhibitory signals (13‑15). CD200 R-like molecules, in contrast, are potentially activating receptors by means of their association with DAP12 (4, 16).
- Rosenblum, M.D. et al. (2006) J. Dermatol. Sci. 41:165.
- Gorczynski, R.M. (2005) Curr. Opin. Invest. Drugs 6:483.
- Barclay, A.N. et al. (2002) Trends Immunol. 23:285.
- Wright, G.J. et al. (2003) J. Immunol. 171:3034.
- Shiratori, I. et al. (2005) J. Immunol. 175:4441.
- Cherwinski, H.M. et al. (2005) J. Immunol. 174:1348.
- Fallarino, F. et al. (2004) J. Immunol. 173:3748.
- Wright, G.J. et al. (2001) Immunology 102:173.
- Hoek, R.M. et al. (2000) Science 290:1768.
- Hatherley, D. and A.N. Barclay (2004) Eur. J. Immunol. 34:1688.
- Hatherley, D. et al. (2005) J. Immunol. 175:2469.
- Gorczynski, R. et al. (2004) J. Immunol. 172:7744.
- Zhang, S. and J.H. Phillips (2006) J. Leukoc. Biol. 79:363.
- Zhang, S. et al. (2004) J. Immunol. 173:6786.
- Jenmalm, M.C. et al. (2006) J. Immunol. 176:191.
- Voehringer, D. et al. (2004) J. Biol. Chem. 279:54117.
Product Datasheets
Citation for Mouse CD200R1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Endothelial CD200 is heterogeneously distributed, regulated and involved in immune cell-endothelium interactions.
Authors: Ko, Ya-Chen, Chien, Hsiung-F, Jiang-Shieh, Ya-Fen, Chang, Chiu-Yun, Pai, Man-Hui, Huang, Jian-Pei, Chen, Hui-Min, Wu, Ching-Hs
J Anat, 2009-01-01;214(1):183-95.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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