Mouse CD69 Fluorescein-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CD69

CD69, also known as Leu 23, AIM, EA-1 and MLR-3, is a 23-34 kDa member of the NK receptor family. It is a homodimeric type II transmembrane protein containing a Ca⁺⁺-independent C-type lectin domain that appears very early following leukocyte activation. Leukocytes known to express CD69 include T cells, B cells, Neutrophils, NK cells and monocytes. Although CD69 ligation has been described as promoting inflammation, some studies suggest that CD69 regulates inflammation by interfering with Th17 differentiation. This may be accomplished by Galectin-1 expression on DC binding to CD69 expressed on CD4⁺ T cells. Over amino acids (aa) 64-199, mouse CD69 shares 78% and 57% aa sequence identity with rat and human CD69, respectively.

Product Datasheets

Related Research Areas

• Acute Lymphoblastic Leukemia
• Airway Inflammation and Remodeling
• B Cell Development and Differentiation
• B Cell Markers
• Eosinophils
• Granulocyte Markers
• Group 1 ILCs
• Isolation, Culture, and Identification of Natural Killer Cells
• Leukocyte Receptors/Markers in Allergy and Asthma
• Leukocyte Receptors/Markers in Tfh Cell Differentiation and Function
• Myeloid Lineage Markers
• Natural Killer T (NKT) Cells
• Neutrophils
• Regulatory T Cells (Tregs)