Mouse CD96 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CD96

Mouse CD96, also known as Tactile, is a 170-180 kDa member of the Ig-Superfamily.  It is expressed on CD4⁺ and CD8⁺ T cells, NK and NKT cells, resting monocytes and gamma δ T cells.  Mouse CD96 binds to CD155 and Nectin-1, and likely participates in cell-to-cell adhesion.  Mature mouse CD96 is a 581 amino acid (aa), type I transmembrane glycoprotein.  It contains a 515 aa extracellular region (aa 22-536) that contains three Ig-like domains, plus a 45 aa cytoplasmic region.  The two N-terminal domains are V-type (aa 24-244), while the distal domain is a C-type structure (aa 250-355).  Unlike human, there is no splice variant in the second V-type domain.  There is, however, a potential isoform that shows a single Cys substitution for aa 437-602.  Over aa 1-536, mouse CD96 shares 55% and 79% aa identity with human and rat CD96, respectively.

Product Datasheets

Product Specific Notices

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Related Research Areas

• Acute Myeloid Leukemia
• Cancer Biomarkers
• Cancer Stem Cell Markers
• Co-stimulatory and Co-inhibitory Molecules
• Leukocyte Receptors/Markers in Allergy and Asthma
• Nectin and Nectin-like Binding Receptors and Ligands
• Search Immune Checkpoint Targets