Mouse CXCL1/KC DuoSet ELISA Summary
* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.
This DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant mouse KC. The suggested diluent is suitable for the analysis of most cell culture supernate samples. Diluents for complex matrices, such as serum and plasma, should be evaluated prior to use in this DuoSet.
Product Features
- Optimized capture and detection antibody pairings with recommended concentrations save lengthy development time
- Development protocols are provided to guide further assay optimization
- Assay can be customized to your specific needs
- Economical alternative to complete kits
Kit Content
- Capture Antibody
- Detection Antibody
- Recombinant Standard
- Streptavidin conjugated to horseradish-peroxidase (Streptavidin-HRP)
Other Reagents Required
DuoSet Ancillary Reagent Kit 2 (5 plates): (Catalog # DY008) containing 96 well microplates, plate sealers, substrate solution, stop solution, plate coating buffer (PBS), wash buffer, and Reagent Diluent Concentrate 2.
The components listed above may be purchased separately:
PBS: (Catalog # DY006), or 137 mM NaCl, 2.7 mM KCl, 8.1 mM Na2HPO4, 1.5 mM KH2PO4, pH 7.2 - 7.4, 0.2 µm filtered
Wash Buffer: (Catalog # WA126), or 0.05% Tween® 20 in PBS, pH 7.2-7.4
Reagent Diluent: (Catalog # DY995), or 1% BSA in PBS, pH 7.2-7.4, 0.2 µm filtered
Substrate Solution: 1:1 mixture of Color Reagent A (H2O2) and Color Reagent B (Tetramethylbenzidine) (Catalog # DY999)
Stop Solution: 2 N H2SO4 (Catalog # DY994)
Microplates: R&D Systems (Catalog # DY990)
Plate Sealers: ELISA Plate Sealers (Catalog # DY992)
Scientific Data
Product Datasheets
Preparation and Storage
Background: CXCL1/GRO alpha/KC/CINC-1
CXCL1/GRO alpha, also known as KC in mouse and CINC-1 in rat, is a member of the CXC family of chemokines. Human CXCL1/GRO alpha is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 57% and 59% amino acid sequence identity with the human protein, respectively. Genome-wide analysis suggests that the protein encoded by the mouse Cxcl3 gene is homologous to human CXCL1/GRO alpha protein. Human CXCL1/GRO alpha can be cleaved into three isoforms CXCL1/GRO alpha (aa 4-73), CXCL1/GRO alpha (aa 5-73), and CXCL1/GRO alpha (aa 6-73) which show higher activity than the full length protein. CXCL1/GRO alpha is secreted by mast cells and macrophages whereupon it acts as a chemoattractant for neutrophils.
Assay Procedure
GENERAL ELISA PROTOCOL
Plate Preparation
- Dilute the Capture Antibody to the working concentration in PBS without carrier protein. Immediately coat a 96-well microplate with 100 μL per well of the diluted Capture Antibody. Seal the plate and incubate overnight at room temperature.
- Aspirate each well and wash with Wash Buffer, repeating the process two times for a total of three washes. Wash by filling each well with Wash Buffer (400 μL) using a squirt bottle, manifold dispenser, or autowasher. Complete removal of liquid at each step is essential for good performance. After the last wash, remove any remaining Wash Buffer by aspirating or by inverting the plate and blotting it against clean paper towels.
- Block plates by adding 300 μL Reagent Diluent to each well. Incubate at room temperature for a minimum of 1 hour.
- Repeat the aspiration/wash as in step 2. The plates are now ready for sample addition.
Assay Procedure
- Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at room temperature.
- Repeat the aspiration/wash as in step 2 of Plate Preparation.
- Add 100 μL of the Detection Antibody, diluted in Reagent Diluent, to each well. Cover with a new adhesive strip and incubate 2 hours at room temperature.
- Repeat the aspiration/wash as in step 2 of Plate Preparation.
- Add 100 μL of the working dilution of Streptavidin-HRP to each well. Cover the plate and incubate for 20 minutes at room temperature. Avoid placing the plate in direct light.
- Repeat the aspiration/wash as in step 2.
- Add 100 μL of Substrate Solution to each well. Incubate for 20 minutes at room temperature. Avoid placing the plate in direct light.
- Add 50 μL of Stop Solution to each well. Gently tap the plate to ensure thorough mixing.
- Determine the optical density of each well immediately, using a microplate reader set to 450 nm. If wavelength correction is available, set to 540 nm or 570 nm. If wavelength correction is not available, subtract readings at 540 nm or 570 nm from the readings at 450 nm. This subtraction will correct for optical imperfections in the plate. Readings made directly at 450 nm without correction may be higher and less accurate.
Citations for Mouse CXCL1/KC DuoSet ELISA
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Targeting PI3K? Pathway for Treating Dengue virus Infection
Authors: da S Santos, FR;Valadão, DF;Bambirra, JL;Moreira, TP;de Souza, CDF;Passos, IBS;Queiroz-Junior, CM;Fagundes, CT;Teixeira, MM;Costa, VV;Souza, DG;
Microbial pathogenesis
Species: Mouse, Transgenic Mouse
Sample Types: Plasma, Tissue Homogenates
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Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype
Authors: Hussain, S;Majumder, N;Mazumder, MHH;Lewis, SE;Olapeju, O;Velayutham, M;Amin, MS;Brundage, K;Kelley, EE;Vanoirbeek, J;
Redox biology
Species: Mouse
Sample Types: Tissue Homogenates, BALF
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CD14 is a decision-maker between Fas-mediated death and inflammation
Authors: Magri, Z;Jetton, D;Muendlein, HI;Connolly, WM;Russell, H;Smirnova, I;Sharma, S;Bunnell, S;Poltorak, A;
Cell reports
Species: Mouse
Sample Types: Serum, Tissue Homogenates
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Cerebral Endothelial CXCR2 Promotes Neutrophil Transmigration into Central Nervous System in LPS-Induced Septic Encephalopathy
Authors: Wu, F;Han, Y;Xiong, Q;Tang, H;Shi, J;Yang, Q;Li, X;Jia, H;Qian, J;Dong, Y;Li, T;Gao, Y;Qian, Z;Wang, H;Wang, T;
Biomedicines
Species: Mouse, Transgenic Mouse
Sample Types: Serum, Tissue Homogenates
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ATG16L1 in myeloid cells limits colorectal tumor growth in ApcMin/+ mice infected with colibactin-producing Escherichia coli via decreasing inflammasome activation
Authors: Salesse, L;Duval, A;Sauvanet, P;Da Silva, A;Barnich, N;Godfraind, C;Dalmasso, G;Nguyen, HTT;
Autophagy
Species: Mouse
Sample Types: Cell Culture Supernates
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Molecular Signatures for Microbe-Associated Colorectal Cancers
Authors: Sayed, IM;Vo, DT;Alcantara, J;Inouye, KM;Pranadinata, RF;Luo, L;Boland, CR;Goyal, NP;Kuo, DJ;Huang, SC;Sahoo, D;Ghosh, P;Das, S;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Organoid
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CD5L as a promising biological therapeutic for treating sepsis
Authors: Oliveira, L;Silva, MC;Gomes, AP;Santos, RF;Cardoso, MS;Nóvoa, A;Luche, H;Cavadas, B;Amorim, I;Gärtner, F;Malissen, B;Mallo, M;Carmo, AM;
Nature communications
Species: Mouse, Transgenic Mouse
Sample Types: Serum
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Species-specific NLRP3 regulation and its role in CNS autoinflammatory diseases
Authors: Koller, BH;Nguyen, M;Snouwaert, JN;Gabel, CA;Ting, JP;
Cell reports
Species: Mouse
Sample Types: Cell Culture Supernates, BALF
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Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes
Authors: Zhang, Y;Bharathi, V;Dokoshi, T;de Anda, J;Ursery, LT;Kulkarni, NN;Nakamura, Y;Chen, J;Luo, EWC;Wang, L;Xu, H;Coady, A;Zurich, R;Lee, MW;Matsui, T;Lee, H;Chan, LC;Schepmoes, AA;Lipton, MS;Zhao, R;Adkins, JN;Clair, GC;Thurlow, LR;Schisler, JC;Wolfgang, MC;Hagan, RS;Yeaman, MR;Weiss, TM;Chen, X;Li, MMH;Nizet, V;Antoniak, S;Mackman, N;Gallo, RL;Wong, GCL;
Proceedings of the National Academy of Sciences of the United States of America
Species: Mouse
Sample Types: Plasma
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P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis
Authors: Li, Z;Barnaby, R;Nymon, A;Roche, C;Koeppen, K;Ashare, A;Hogan, DA;Gerber, SA;Taatjes, DJ;Hampton, TH;Stanton, BA;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: BALF
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Metformin inhibits paclitaxel-induced mechanical allodynia by activating opioidergic pathways and reducing cytokines production in the dorsal root ganglia and thalamus
Authors: Morais, MÍ;Braga, AV;Silva, RRL;Barbosa, BCM;Costa, SOAM;Rodrigues, FF;Melo, ISF;Matos, RC;Carobin, NV;Sabino, AP;Coelho, MM;Machado, RR;
Cytokine
Species: Mouse
Sample Types: Tissue Homogenates
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Platelet-activating factor and protease-activated receptor 2 cooperate to promote neutrophil recruitment and lung inflammation through nuclear factor-kappa B transactivation
Authors: Silva, IS;Almeida, AD;Lima Filho, ACM;Fernandes-Braga, W;Barra, A;Oliveira, HMC;Cassali, GD;Capettini, LSA;Menezes, GB;Alvarez-Leite, JI;Leite, MF;Klein, A;
Scientific reports
Species: Mouse
Sample Types: BALF
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IL-17A + group 2 innate lymphoid cells elicit mixed airway inflammation in chronic obstructive pulmonary disease
Authors: Flayer, CH;Linderholm, AL;Ge, MQ;Juarez, M;Franzi, L;Tham, T;Teuber, M;Liao, SY;Schivo, M;Kuhn, B;Zeki, A;Haczku, A;
medRxiv : the preprint server for health sciences
Species: Mouse
Sample Types: BALF
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A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by Betacoronavirus
Authors: Pereira, RDD;Rabelo, RAN;Oliveira, NFM;Porto, SLT;Andrade, ACDSP;Queiroz-Junior, CM;Barbosa, CLN;de Souza-Costa, LP;Santos, FRDS;Oliveira, FBR;da Silva, BLV;Umezu, HL;Ferreira, R;da Silva, GSF;Cruz, JS;Teixeira, MM;Costa, VV;Machado, FS;
Viruses
Species: Mouse
Sample Types: Tissue Homogenates
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The small non-coding RNA B11 regulates multiple facets of Mycobacterium abscessus virulence
Authors: Bar-Oz, M;Martini, MC;Alonso, MN;Meir, M;Lore, NI;Miotto, P;Riva, C;Angala, SK;Xiao, J;Masiello, CS;Misiakou, MA;Sun, H;Moy, JK;Jackson, M;Johansen, HK;Cirillo, DM;Shell, SS;Barkan, D;
PLoS pathogens
Species: Mouse
Sample Types: Tissue Homogenates
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Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophages
Authors: Kinsella, RL;Kimmey, JM;Smirnov, A;Woodson, R;Gaggioli, MR;Chavez, SM;Kreamalmeyer, D;Stallings, CL;
PLoS biology
Species: Mouse
Sample Types: Cell Culture Supernates
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CARD-only proteins regulate in�vivo inflammasome responses and ameliorate gout
Authors: S Devi, M Indramohan, E Jäger, J Carriere, LH Chu, L de Almeida, DR Greaves, C Stehlik, A Dorfleutne
Cell Reports, 2023-03-16;42(3):112265.
Species: Mouse
Sample Types: Cell Culture Supernates
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STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells
Authors: R Mikyskova, O Sapeg, M Psotka, O Novotny, Z Hodny, S Balintova, D Malinak, J Svobodova, R Andrys, D Rysanek, K Musilek, M Reinis
Molecular Medicine Reports, 2023-02-24;27(4):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Macrophage-targeted lipid nanoparticle delivery of microRNA-146a to mitigate hemorrhagic shock-induced acute respiratory distress syndrome
Authors: Q Fei, EM Shalosky, R Barnes, VC Shukla, MN Ballinger, L Farkas, RJ Lee, SN Ghadiali, JA Englert
bioRxiv : the preprint server for biology, 2023-02-19;0(0):.
Species: Mouse
Sample Types: BALF
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Cardiac Myocyte-Specific Overexpression of FASTKD1 Prevents Ventricular Rupture After Myocardial Infarction
Authors: KD Marshall, PJ Klutho, L Song, R Roy, M Krenz, CP Baines
Journal of the American Heart Association, 2023-02-15;12(4):e025867.
Species: Mouse, Transgenic Mouse
Sample Types: Tissue Homogenates
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ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
Authors: H Jeong, EH Hong, JH Ahn, J Cho, JH Jeong, CW Kim, BI Yoon, JH Koo, YY Park, YM Yang, T Iwawaki, BA Vallance, SY Chang, HJ Ko
Experimental & Molecular Medicine, 2023-02-09;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
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SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses
Authors: L Chen, V Shi, S Wang, R Freeman, F Ruiz, K Jayachandr, J Zhang, P Cosper, L Sun, CJ Luke, C Spina, PW Grigsby, JK Schwarz, S Markovina
bioRxiv : the preprint server for biology, 2023-02-03;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
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A hierarchy of cell death pathways confers layered resistance to shigellosis in mice
Authors: JL Roncaioli, JP Babirye, RA Chavez, FL Liu, EA Turcotte, AY Lee, CF Lesser, RE Vance
Elife, 2023-01-16;12(0):.
Species: Mouse
Sample Types: Fecal Supernates
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Role of Myeloid Cell-Specific TLR9 in Mitochondrial DNA-Induced Lung Inflammation in Mice
Authors: KG Dimasuay, B Berg, N Schaunaman, HW Chu
International Journal of Molecular Sciences, 2023-01-04;24(2):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
Authors: FP Veras, GA Publio, BM Melo, DS Prado, T Norbiato, NT Cecilio, C Hiroki, LEA Damasceno, R Jung, JE Toller-Kaw, TV Martins, SF Assunção, D Lima, MG Alves, GV Vieira, LA Tavares, ALR Alves-Reze, SH Karbach, HI Nakaya, TM Cunha, CS Souza, FQ Cunha, KU Sales, A Waisman, JC Alves-Filh
Cell Reports, 2022-12-27;41(13):111897.
Species: Mouse
Sample Types: Cell Culture Supernates
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KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer
Authors: J Yang, L Jin, HS Kim, F Tian, Z Yi, K Bedi, M Ljungman, M Pasca di M, H Crawford, J Shi
Cancer Research, 2022-11-15;0(0):OF1-OF14.
Species: Mouse
Sample Types: Cell Culture Supernates
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Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment
Authors: RA Keogh, AL Haeberle, CJ Langouët-A, JS Kavanaugh, EP Schmidt, GD Moore, AR Horswill, KS Doran
Science Advances, 2022-11-11;8(45):eadd3221.
Species: Mouse, Transgenic Mouse
Sample Types: Tissue Homogenates
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The effects of intermittent hypoxia on hepatic expression of fatty acid translocase CD36 in lean and diet-induced obese mice
Authors: Y Ji, Y Liang, PH Chu, M Ge, SC Yeung, MS Man Ip, JC Wo Mak
Biomedical journal, 2022-10-13;0(0):.
Species: Mouse
Sample Types: Serum
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A neutrophil-B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4
Authors: R Gawish, B Maier, G Obermayer, ML Watzenboec, AD Gorki, F Quattrone, A Farhat, K Lakovits, A Hladik, A Korosec, A Alimohamma, I Mesteri, F Oberndorfe, F Oakley, J Brain, L Boon, I Lang, CJ Binder, S Knapp
Elife, 2022-09-30;11(0):.
Species: Mouse
Sample Types: Plasma
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Interleukin-10 Deficiency Impacts on TNF-Induced NFkappaB Regulated Responses In Vivo
Authors: S Papoutsopo, L Pollock, JM Williams, MMLF Abdul-Mahd, R Dobbash, CA Duckworth, BJ Campbell
Biology, 2022-09-20;11(10):.
Species: Mouse, Transgenic Mouse
Sample Types: Serum
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Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity
Authors: P Boroumand, DC Prescott, T Mukherjee, PJ Bilan, M Wong, J Shen, I Tattoli, Y Zhou, A Li, T Sivasubram, N Shi, LY Zhu, Z Liu, C Robbins, DJ Philpott, SE Girardin, A Klip
Elife, 2022-09-20;11(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
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Nanoparticles reduce monocytes within the lungs to improve outcomes after influenza virus infection in aged mice
Authors: WJ Kelley, KM Wragg, J Chen, T Murthy, Q Xu, MT Boyne Ii, JR Podojil, A Elhofy, DR Goldstein
JCI Insight, 2022-08-08;0(0):.
Species: Mouse
Sample Types: BALF
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HIF-1alpha induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury
Authors: PS Woods, LM Kimmig, KA Sun, AY Meliton, OR Shamaa, Y Tian, R Cetin-Atal, WW Sharp, RB Hamanaka, GM Mutlu
Elife, 2022-07-13;11(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
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In vitro and in vivo Characterization of Host-Pathogen Interactions of the L3881 Candida albicans Clinical Isolate
Authors: PHF Sucupira, TR Moura, ILS Gurgel, TTP Pereira, ACB Padovan, MM Teixeira, D Bahia, FM Soriani
Frontiers in Microbiology, 2022-07-11;13(0):901442.
Species: Mouse
Sample Types: Cell Culture Supernates
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Simple gene signature to assess murine fibroblast polarization
Authors: E Ledoult, M Jendoubi, A Collet, T Guerrier, A Largy, S Speca, S Vivier, F Bray, M Figeac, E Hachulla, M Labalette, F Leprêtre, S Sebda, S Sanges, C Rolando, V Sobanski, S Dubucquoi, D Launay
Scientific Reports, 2022-07-11;12(1):11748.
Species: Mouse
Sample Types: Cell Culture Supernates
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Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release
Authors: HOJ Morad, S Luqman, LG Pinto, KP Cunningham, B Vilar, G Clayton, M Shankar-Ha, PA McNaughton
Scientific Reports, 2022-06-30;12(1):11078.
Species: Mouse
Sample Types: BALF
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ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF
Authors: HI Muendlein, WM Connolly, Z Magri, D Jetton, I Smirnova, A Degterev, S Balachandr, A Poltorak
Proceedings of the National Academy of Sciences of the United States of America, 2022-06-06;119(24):e2113872119.
Species: Mouse
Sample Types: Cell Culture Supernates
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The Therapeutic Treatment with the GAG-Binding Chemokine Fragment CXCL9(74-103) Attenuates Neutrophilic Inflammation and Lung Dysfunction during Klebsiella pneumoniae Infection in Mice
Authors: D Boff, RC Russo, H Crijns, VLS de Oliveir, MS Mattos, PE Marques, GB Menezes, AT Vieira, MM Teixeira, P Proost, FA Amaral
International Journal of Molecular Sciences, 2022-06-02;23(11):.
Species: Mouse
Sample Types: BALF
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IL-22 regulates inflammatory responses to agricultural dust-induced airway inflammation
Authors: A Ulu, S Sveiven, A Bilg, JV Velazquez, M Diaz, M Mukherjee, AG Yuil-Valde, S Kota, A Burr, A Najera, TM Nordgren
Toxicology and Applied Pharmacology, 2022-05-05;0(0):116044.
Species: Mouse
Sample Types: BALF
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Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice
Authors: A Moshensky, CS Brand, H Alhaddad, J Shin, JA Masso-Silv, I Advani, D Gunge, A Sharma, S Mehta, A Jahan, S Nilaad, J Olay, W Gu, T Simonson, D Almarghala, J Pham, S Perera, K Park, R Al-Kolla, H Moon, S Das, M Byun, Z Shah, Y Sari, J Heller Bro, LE Crotty Ale
Elife, 2022-04-12;11(0):.
Species: Mouse
Sample Types: BALF
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Liposomal Dexamethasone Reduces A/H1N1 Influenza-Associated Morbidity in Mice
Authors: JW Kwon, H Quan, J Song, H Chung, D Jung, JJ Hong, YR Na, SH Seok
Frontiers in Microbiology, 2022-04-12;13(0):845795.
Species: Mouse
Sample Types: BALF
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Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1
Authors: KC Ngamsri, A Fuhr, K Schindler, M Simelitidi, M Hagen, Y Zhang, J Gamper-Tsi, FM Konrad
Cells, 2022-03-24;11(7):.
Species: Mouse
Sample Types: BALF
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Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases
Authors: R Nakashima, H Nohara, N Takahashi, A Nasu, M Hayashi, T Kishimoto, S Kamei, H Fujikawa, K Maruta, T Kawakami, Y Eto, K Ueno-Shuto, MA Suico, H Kai, T Shuto
Journal of pharmacological sciences, 2022-03-23;149(2):37-45.
Species: Mouse
Sample Types: BALF
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The Crohn Disease-associated ATG16L1T300A polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling
Authors: P Gao, H Liu, H Huang, Y Sun, B Jia, B Hou, X Zhou, W Strober, F Zhang
Autophagy, 2022-02-27;0(0):1-15.
Species: Human
Sample Types: Cell Culture Supernates
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Fibrotic lung disease inhibits innate immune responses to Staphylococcal pneumonia via impaired neutrophil and macrophage function
Authors: HI Warheit-Ni, SJ Edwards, S SenGupta, CA Parent, X Zhou, DN O'Dwyer, BB Moore
JCI Insight, 2022-02-22;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
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ADAM8 signaling drives neutrophil migration and ARDS severity
Authors: C Conrad, D Yildiz, SJ Cleary, A Margraf, L Cook, U Schlomann, B Panaretou, JL Bowser, H Karmouty-Q, J Li, NK Berg, SC Martin, A Aljohmani, SF Moussavi-H, KM Wang, JJ Tian, M Magnen, C Valet, L Qiu, JP Singer, HK Eltzschig, CAPSys Stu, W Bertrams, S Herold, N Suttorp, B Schmeck, ZT Ball, A Zarbock, MR Looney, JW Bartsch
JCI Insight, 2022-02-08;7(3):.
Species: Mouse
Sample Types: BALF
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Chemerin Overexpression in the Liver Protects against Inflammation in Experimental Non-Alcoholic Steatohepatitis
Authors: R Pohl, S Feder, EM Haberl, L Rein-Fisch, TS Weiss, M Spirk, A Bruckmann, N McMullen, CJ Sinal, C Buechler
Biomedicines, 2022-01-07;10(1):.
Species: Mouse
Sample Types: Cell Culture Supernates
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MTMR14 Alleviates Chronic Obstructive Pulmonary Disease as a Regulator in Inflammation and Emphysema
Authors: Y Gu, J Chen, Q Huang, Y Zhan, T Wang, J Wu, J Zhao, Z Zeng, Y Lv, C Xiao, J Xie
Oxidative Medicine and Cellular Longevity, 2022-01-07;2022(0):9300269.
Species: Mouse
Sample Types: BALF
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Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis
Authors: BY Lee, EKJ Hogg, CR Below, A Kononov, A Blanco-Gom, F Heider, J Xu, C Hutton, X Zhang, T Scheidt, K Beattie, A Lamarca, M McNamara, JW Valle, C Jørgensen
Nature Communications, 2021-12-17;12(1):7336.
Species: Mouse
Sample Types: Tissue Homogenates
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CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling
Authors: KC Ngamsri, RA Putri, C Jans, K Schindler, A Fuhr, Y Zhang, J Gamper-Tsi, S Ehnert, FM Konrad
International Journal of Molecular Sciences, 2021-12-17;22(24):.
Species: Mouse
Sample Types: Plasma
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Soluble Non-Starch Polysaccharides From Plantain (Musa x paradisiaca L.) Diminish Epithelial Impact of Clostridioides difficile
Authors: HL Simpson, CL Roberts, LM Thompson, CR Leiper, N Gittens, E Trotter, CA Duckworth, S Papoutsopo, F Miyajima, P Roberts, N O'Kennedy, JM Rhodes, BJ Campbell
Frontiers in Pharmacology, 2021-12-10;12(0):766293.
Species: Mouse
Sample Types: Cell Culture Supernates
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A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence
Authors: BL Spencer, U Tak, JC Mendonça, PE Nagao, M Niederweis, KS Doran
PloS Pathogens, 2021-12-06;17(12):e1010121.
Species: Mouse
Sample Types: Tissue Homogenates
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alpha1-Antitrypsin attenuates acute rejection of orthotopic murine lung allografts
Authors: T Nakagiri, S Wrenger, K Sivaraman, F Ius, T Goecke, P Zardo, V Grau, T Welte, A Haverich, AK Knöfel, S Janciauski
Respiratory Research, 2021-11-17;22(1):295.
Species: Mouse
Sample Types: Serum
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DRP1-Mediated Mitochondrial Fission Regulates Lung Epithelial Response to Allergen
Authors: SR Bruno, A Kumar, ZF Mark, R Chandrasek, E Nakada, N Chamberlai, B Mihavics, J Walzer, J Cahoon, AE Dixon, B Cunniff, V Anathy
International Journal of Molecular Sciences, 2021-10-15;22(20):.
Species: Mouse
Sample Types: Tissue Homogenates
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Oxidized carbon black nanoparticles induce endothelial damage through C-X-C chemokine receptor 3-mediated pathway
Authors: N Majumder, M Velayutham, D Bitounis, VK Kodali, MH Hasan Mazu, J Amedro, VV Khramtsov, A Erdely, T Nurkiewicz, P Demokritou, EE Kelley, S Hussain
Redox Biology, 2021-10-04;47(0):102161.
Species: Mouse
Sample Types: BALF
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Limited role of the spleen in a mouse model of trained immunity: Impact on neutrophilia
Authors: AV Ferreira, RF Uijen, O Bulut, MI de Jonge, J Domínguez-, MG Netea
Journal of leukocyte biology, 2021-10-01;0(0):.
Species: Mouse
Sample Types: Serum
-
Signaling through Syk or CARD9 Mediates Species-Specific Anti-Candida Protection in Bone Marrow Chimeric Mice
Authors: E Zajta, K Csonka, A Tóth, L Tiszlavicz, T Németh, A Orosz, Á Novák, M Csikós, C Vágvölgyi, A Mócsai, A Gácser
MBio, 2021-08-31;12(4):e0160821.
Species: Mouse, Transgenic Mouse
Sample Types: Cell Culture Supernates
-
Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1alpha kinase inhibitor KIRA6 through HSP60 targeting
Authors: N Rufo, D Korovesis, S Van Eygen, R Derua, AD Garg, F Finotello, M Vara-Perez, J Rožanc, M Dewaele, PA de Witte, LG Alexopoulo, S Janssens, L Sinkkonen, T Sauter, SHL Verhelst, P Agostinis
Cell Death and Differentiation, 2021-08-27;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
Authors: Z Yang, G Xu, B Wang, Y Liu, L Zhang, T Jing, M Tang, X Xu, K Jiao, L Xiang, Y Fu, D Tang, X Zhang, W Jin, G Zhuang, X Zhao, Y Liu
Nature Communications, 2021-08-11;12(1):4852.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure
Authors: N Majumder, WT Goldsmith, VK Kodali, M Velayutham, SA Friend, VV Khramtsov, TR Nurkiewicz, A Erdely, PC Zeidler-Er, V Castranova, JR Harkema, EE Kelley, S Hussain
Redox Biology, 2021-08-05;46(0):102092.
Species: Mouse
Sample Types: BALF
-
Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of alpha7 Nicotinic Acetylcholine Receptor
Authors: NM Pinheiro, R Banzato, I Tibério, MAM Prado, VF Prado, AK Hamouda, CM Prado
International Journal of Molecular Sciences, 2021-07-14;22(14):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host
Authors: DJ Levy, A Goundry, RSS Laires, TFR Costa, CM Novo, DJ Grab, JC Mottram, APCA Lima
PloS Neglected Tropical Diseases, 2021-06-21;15(6):e0009526.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus
Authors: A Doni, R Parente, I Laface, E Magrini, C Cunha, FS Colombo, JF Lacerda, A Campos, SN Mapelli, F Petroni, R Porte, T Schorn, A Inforzato, T Mercier, K Lagrou, J Maertens, JD Lambris, B Bottazzi, C Garlanda, M Botto, A Carvalho, A Mantovani
Nature Communications, 2021-06-18;12(1):3739.
Species: Mouse
Sample Types: Cell Culture Supernates
-
PB1-F2 amyloid-like fibers correlate with pro-inflammatory signaling and respiratory distress in influenza-infected mice
Authors: C Chevalier, O Leymarie, L Sedano, B Da Costa, CA Richard, P Maisonnass, M Réfregiers, F Jamme, R Le Goffic
The Journal of Biological Chemistry, 2021-06-17;0(0):100885.
Species: Mouse
Sample Types: BALF
-
A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts: Role of DHA in repetitive organic dust exposure
Authors: A Ulu, A Burr, AJ Heires, J Pavlik, T Larsen, PA Perez, C Bravo, NV DiPatrizio, M Baack, DJ Romberger, TM Nordgren
The Journal of nutritional biochemistry, 2021-06-12;0(0):108797.
Species: Mouse
Sample Types: BALF
-
Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice
Authors: MG Daskalaki, K Axarlis, T Aspevik, M Orfanakis, O Kolliniati, I Lapi, M Tzardi, E Dermitzaki, M Venihaki, K Kousoulaki, C Tsatsanis
Marine Drugs, 2021-05-28;19(6):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Reduced CXCL1 production by endogenous IL-37 expressing dendritic cells does not affect T cell activation
Authors: M Kouwenberg, WPC Pulskens, L Diepeveen, M Bakker-van, CA Dinarello, MG Netea, LB Hilbrands, J van der Vl
PLoS ONE, 2021-05-24;16(5):e0251809.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice
Authors: MTP de Oliveir, DS Coutinho, SS Guterres, AR Pohlmann, PMRE Silva, MA Martins, A Bernardi
Pharmaceutics, 2021-05-10;13(5):.
Species: Mouse
Sample Types: Tissue Homogenates
-
The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity
Authors: G Cavalli, IW Tengesdal, M Gresnigt, T Nemkov, RJW Arts, J Domínguez-, R Molteni, D Stefanoni, E Cantoni, L Cassina, S Giugliano, K Schraa, TS Mills, EM Pietras, EZ Eisenmenss, L Dagna, A Boletta, A D'Alessand, LAB Joosten, MG Netea, CA Dinarello
Cell Reports, 2021-04-06;35(1):108955.
Species: Mouse
Sample Types: Tissue Homogenates
-
Aryl hydrocarbon receptor (Ahr)-dependent Il-22 expression by type 3 innate lymphoid cells control of acute joint inflammation
Authors: R Nehmar, L Fauconnier, J Alves-Filh, D Togbe, A DeCauwer, S Bahram, M Le Bert, B Ryffel, P Georgel
Journal of Cellular and Molecular Medicine, 2021-03-18;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Oxygen conditions oscillating between hypoxia and hyperoxia induce different effects in the pulmonary endothelium compared to constant oxygen conditions
Authors: P Wohlrab, M Johann Dan, W Schaubmayr, A Tiboldi, K Krenn, K Markstalle, R Ullrich, K Ulrich Kle, V Tretter
Physiological Reports, 2021-02-01;9(3):e14590.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo
Authors: S Estfanous, K Krause, MNK Anne, M Eltobgy, K Caution, A Abu Khweek, K Hamilton, A Badr, K Daily, C Carafice, D Baetzhold, X Zhang, T Li, H Wen, MA Gavrilin, H Haffez, S Soror, AO Amer
Scientific Reports, 2021-01-13;11(1):855.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation
Authors: CM Bobba, Q Fei, V Shukla, H Lee, P Patel, RK Putman, C Spitzer, M Tsai, MD Wewers, RJ Lee, JW Christman, MN Ballinger, SN Ghadiali, JA Englert
Nature Communications, 2021-01-12;12(1):289.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Respiratory Epithelial Cells Respond to Lactobacillus plantarum but Provide No Cross-Protection against Virus-Induced Inflammation
Authors: E Mai, CM Percopo, AR Limkar, AC Sek, M Ma, HF Rosenberg
Viruses, 2020-12-22;13(1):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle
Authors: DC Badgujar, A Anil, AE Green, MV Surve, S Madhavan, A Beckett, IA Prior, BK Godsora, SB Patil, PK More, SG Sarkar, A Mitchell, R Banerjee, PS Phale, TJ Mitchell, DR Neill, P Bhaumik, A Banerjee
PloS Pathogens, 2020-11-20;16(11):e1009016.
Species: Mouse
Sample Types: Tissue Homogenates
-
Different experimental multiple trauma models induce comparable inflammation and organ injury
Authors: B Relja, B Yang, K Bundkirche, B Xu, K Köhler, C Neunaber
Sci Rep, 2020-11-19;10(1):20185.
Species: Mouse
Sample Types: Plasma
-
Macrophage Immune Memory Controls Endometriosis in Mice and Humans
Authors: M Jeljeli, LGC Riccio, S Chouzenoux, F Moresi, L Toullec, L Doridot, C Nicco, M Bourdon, L Marcellin, P Santulli, MS Abrão, C Chapron, F Batteux
Cell Rep, 2020-11-03;33(5):108325.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease
Authors: DM de Graaf, RJA Maas, SP Smeekens, E Eisenmesse, JS Redzic, MM Helsen, NE Powers, S Li, V Kalabokis, MS Gresnigt, LAB Joosten, CA Dinarello, FL van de Vee
Cytokine, 2020-10-28;137(0):155334.
Species: Mouse
Sample Types: Cell Culture Supernates
-
The Small RNA ErsA Plays a Role in the Regulatory Network of Pseudomonas aeruginosa Pathogenicity in Airway Infections
Authors: S Ferrara, A Rossi, S Ranucci, I De Fino, A Bragonzi, C Cigana, G Bertoni
mSphere, 2020-10-14;5(5):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
EBioMedicine, 2020-09-23;60(0):102984.
Species: Mouse
Sample Types: Cell Culture Supernates
-
&beta-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology
Authors: DC Shippy, C Wilhelm, PA Viharkumar, TJ Raife, TK Ulland
Journal of Neuroinflammation, 2020-09-21;17(1):280.
Species: Mouse
Sample Types: Cell Culture Supernates
-
The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells
Authors: IM Sayed, A Chakrabort, AA Abd El-Haf, A Sharma, AZ Sahan, WJM Huang, D Sahoo, P Ghosh, TK Hazra, S Das
Cells, 2020-08-28;9(9):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling
Authors: VK Bhosle, T Mukherjee, YW Huang, S Patel, BWF Pang, GY Liu, M Glogauer, JY Wu, DJ Philpott, S Grinstein, LA Robinson
Nat Commun, 2020-08-17;11(1):4112.
Species: Mouse
Sample Types: Serum
-
Leptospiral LPS escapes mouse TLR4 internalization and TRIF?associated antimicrobial responses through O antigen and associated lipoproteins
Authors: D Bonhomme, I Santecchia, F Vernel-Pau, M Caroff, P Germon, G Murray, B Adler, IG Boneca, C Werts
PLoS Pathog., 2020-08-13;16(8):e1008639.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Methyl-donor supplementation prevents intestinal colonization by Adherent-Invasive E. coli in a mouse model of Crohn's disease
Authors: E Gimier, M Chervy, A Agus, A Sivignon, E Billard, M Privat, S Viala, R Minet-Quin, A Buisson, E Vazeille, N Barnich, J Denizot
Sci Rep, 2020-07-31;10(1):12922.
Species: Mouse
Sample Types: Cell Culture Supernates, Tissue Homogenates
-
Biological Characterization of Commercial Recombinantly Expressed Immunomodulating Proteins Contaminated with Bacterial Products in the Year 2020: The SAA3 Case
Authors: S Abouelasra, M De Bondt, N Berghmans, M Gouwy, VLS de Oliveir, SC Oliveira, FA Amaral, P Proost, J Van Damme, S Struyf, M De Buck
Mediators Inflamm., 2020-07-06;2020(0):6087109.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Helicobacter pylori infection down-regulates the DNA glycosylase NEIL2,� resulting in increased genome damage and inflammation in gastric epithelial cells
Authors: IM Sayed, AZ Sahan, T Venkova, A Chakrabort, D Mukhopadhy, D Bimczok, EJ Beswick, VE Reyes, I Pinchuk, D Sahoo, P Ghosh, TK Hazra, S Das
J. Biol. Chem., 2020-06-09;0(0):.
Species: Mouse, Transgenic Mouse
Sample Types: Cell Culture Supernates
-
Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNF&alpha-induced NF-?B signaling
Authors: N Weinelt, C Karathanas, S Smith, J Medler, S Malkusch, S Fulda, H Wajant, M Heilemann, SJL van Wijk
J. Leukoc. Biol., 2020-05-13;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Recombinant Protein-Based Nanoparticles: Elucidating their Inflammatory Effects In Vivo and their Potential as a New Therapeutic Format
Authors: L Gifre-Reno, E Ugarte-Ber, E Martens, L Boon, O Cano-Garri, E Martínez-N, T Luque, R Roca-Pinil, Ò Conchillo-, N Ferrer-Mir, A Villaverde, G Opdenakker, E Garcia-Fru, A Arís
Pharmaceutics, 2020-05-13;12(5):.
Species: Mouse
Sample Types: Complex Sample Type
-
The role of Staphylococcus aureus lipoproteins in hematogenous septic arthritis
Authors: M Mohammad, Z Hu, A Ali, PK Kopparapu, M Na, A Jarneborn, MDN Stroparo, MT Nguyen, A Karlsson, F Götz, R Pullerits, T Jin
Sci Rep, 2020-05-13;10(1):7936.
Species: Mouse
Sample Types: Serum
-
Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice
Authors: A Sünderhauf, R Pagel, A Künstner, AE Wagner, J Rupp, SM Ibrahim, S Derer, C Sina
Nutrients, 2020-04-17;12(4):.
Species: Mouse
Sample Types: Serum
-
The C5a/C5aR2 axis promotes renal inflammation and tissue damage
Authors: T Zhang, KY Wu, N Ma, LL Wei, M Garstka, W Zhou, K Li
JCI Insight, 2020-04-09;5(7):.
Species: Mouse
Sample Types: Tissue Lysates
-
Herbal Combinational Medication of Glycyrrhiza glabra, Agastache rugosa Containing Glycyrrhizic Acid, Tilianin Inhibits Neutrophilic Lung Inflammation by Affecting CXCL2, Interleukin-17/STAT3 Signal Pathways in a Murine Model of COPD
Authors: SH Kim, JH Hong, WK Yang, JH Geum, HR Kim, SY Choi, YM Kang, HJ An, YC Lee
Nutrients, 2020-03-27;12(4):.
Species: Mouse
Sample Types: BALF
-
IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network
Authors: L Sun, M Girnary, L Wang, Y Jiao, E Zeng, K Mercer, J Zhang, JT Marchesan, N Yu, K Moss, YL Lei, S Offenbache, S Zhang
J. Immunol., 2020-03-13;204(8):2177-2191.
Species: Mouse, Transgenic Mouse
Sample Types: Serum
-
Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis
Authors: YM Khaw, C Cunningham, A Tierney, M Sivaguru, M Inoue
J Neuroinflammation, 2020-02-04;17(1):49.
Species: Mouse
Sample Types: Serum
-
Neutrophils do not impact viral load or the peak of disease severity during RSV infection
Authors: F Kirsebom, C Michalaki, M Agueda-Oya, C Johansson
Sci Rep, 2020-01-24;10(1):1110.
Species: Mouse
Sample Types: Tissue Homogenates
-
Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation
Authors: HI Muendlein, J Sarhan, BC Liu, WM Connolly, SA Schworer, I Smirnova, AY Tang, V Ilyukha, J Pietruska, S Tahmasebi, N Sonenberg, A Degterev, A Poltorak
Cell Rep, 2020-01-21;30(3):699-713.e4.
Species: Mouse
Sample Types: Cell Culture Media
-
Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophils
Authors: CL Hsu, KD Chhiba, R Krier-Burr, S Hosakoppal, S Berdnikovs, ML Miller, PJ Bryce
PLoS ONE, 2020-01-15;15(1):e0226701.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases
Authors: HQ Tran, RE Ley, AT Gewirtz, B Chassaing
Nat Commun, 2019-12-11;10(1):5650.
Species: Mouse
Sample Types: Serum
-
PASylation of IL-1 Receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis
Authors: NE Powers, B Swartzwelt, C Marchetti, DM de Graaf, A Lerchner, M Schlapschy, R Datar, U Binder, CK Edwards, A Skerra, CA Dinarello
J. Biol. Chem., 2019-12-09;0(0):.
Species: Mouse
Sample Types: Cell Lysates
-
Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation
Authors: A Rahman, KM Henry, KD Herman, AAR Thompson, HM Isles, C Tulotta, D Sammut, JJ Rougeot, N Khoshaein, AE Reese, K Higgins, C Tabor, I Sabroe, WJ Zuercher, CO Savage, AH Meijer, MK Whyte, DH Dockrell, SA Renshaw, LR Prince
Elife, 2019-10-15;8(0):.
Species: Mouse
Sample Types: Peritoneal Lavage Fluid
-
Fungal biofilm morphology impacts hypoxia fitness and disease progression
Authors: CH Kowalski, JD Kerkaert, KW Liu, MC Bond, R Hartmann, CD Nadell, JE Stajich, RA Cramer
Nat Microbiol, 2019-09-23;0(0):.
Species: Mouse
Sample Types: BALF
-
Pseudomonas aeruginosa Lipoxygenase LoxA Contributes to Lung Infection by Altering the Host Immune Lipid Signaling
Authors: E Morello, T Pérez-Bere, C Boisseau, T Baranek, A Guillon, D Bréa, P Lanotte, X Carpena, N Pietrancos, V Hervé, R Ramphal, N Cenac, M Si-Tahar
Front Microbiol, 2019-08-14;10(0):1826.
Species: Mouse
Sample Types: BALF
-
Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis
Authors: BE Hsu, S Tabariès, RM Johnson, S Andrzejews, J Senecal, C Lehuédé, MG Annis, EH Ma, S Völs, L Ramsay, R Froment, A Monast, IR Watson, Z Granot, RG Jones, J St-Pierre, PM Siegel
Cell Rep, 2019-06-25;27(13):3902-3915.e6.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Oral administration of EPA-rich oil impairs collagen reorganization due to elevated production of IL-10 during skin wound healing in mice
Authors: B Burger, CMC Kühl, T Candreva, RDS Cardoso, JR Silva, BG Castelucci, SR Consonni, HL Fisk, PC Calder, MAR Vinolo, HG Rodrigues
Sci Rep, 2019-06-24;9(1):9119.
Species: Mouse
Sample Types: Tissue Homogenates
-
Role of adipose tissue inflammation in fat pad loss induced by fasting in lean and mildly obese mice
Authors: DR Lacerda, KA Costa, ALM Silveira, DF Rodrigues, AN Silva, JL Sabino, V Pinho, GB Menezes, DD Soares, MM Teixeira, AVM Ferreira
J. Nutr. Biochem., 2019-06-21;72(0):108208.
Species: Mouse
Sample Types: Tissue Homogenates
-
The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus
Authors: M Mohammad, MT Nguyen, C Engdahl, M Na, A Jarneborn, Z Hu, A Karlsson, R Pullerits, A Ali, F Götz, T Jin
PLoS Pathog., 2019-06-21;15(6):e1007877.
Species: Mouse
Sample Types: Tissue Homogenates
-
Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation
Authors: N Schaunaman, A Sanchez, KG Dimasuay, N Pavelka, M Numata, R Alam, RJ Martin, HW Chu
Infect. Immun., 2019-06-20;87(7):.
Species: Mouse
Sample Types: BALF
-
The immunoreceptor CD300a controls the intensity of inflammation and dysfunction in a model of Ag-induced arthritis in mice
Authors: BVS Valiate, RU Alvarez, L Karra, CM Queiroz-Jú, FA Amaral, F Levi-Schaf, MM Teixeira
J. Leukoc. Biol., 2019-05-20;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection
Authors: I Santecchia, F Vernel-Pau, O Rasid, J Quintin, M Gomes-Sole, IG Boneca, C Werts
PLoS Pathog., 2019-05-20;15(5):e1007811.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers
Authors: EM Nakada, NR Bhakta, BR Korwin-Mih, A Kumar, N Chamberlai, SR Bruno, DG Chapman, SM Hoffman, N Daphtary, M Aliyeva, CG Irvin, AE Dixon, PG Woodruff, S Amin, ME Poynter, DH Desai, V Anathy
JCI Insight, 2019-05-02;4(9):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism
Authors: JL Fachi, JS Felipe, LP Pral, BK da Silva, RO Corrêa, MCP de Andrade, DM da Fonseca, PJ Basso, NOS Câmara, ÉL de Sales E, F Dos Santos, SES Guima, AM Thomas, JC Setubal, YT Magalhães, FL Forti, T Candreva, HG Rodrigues, MB de Jesus, SR Consonni, ADS Farias, P Varga-Weis, MAR Vinolo
Cell Rep, 2019-04-16;27(3):750-761.e7.
Species: Mouse
Sample Types: Tissue Homogenates
-
The three cytokines IL-1?, IL-18, and IL-1? share related but distinct secretory routes
Authors: VS Tapia, MJD Daniels, P Palazón-Ri, M Dewhurst, NM Luheshi, J Rivers-Aut, J Green, E Redondo-Ca, P Kaldis, G Lopez-Cast, D Brough
J. Biol. Chem., 2019-04-02;294(21):8325-8335.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Epigenetic Regulation of IL-17-Induced Chemokines in Lung Epithelial Cells
Authors: J Luo, X An, Y Yao, C Erb, A Ferguson, JK Kolls, S Fan, K Chen
Mediators Inflamm., 2019-03-17;2019(0):9050965.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile
Authors: P Mamareli, F Kruse, C Friedrich, N Smit, T Strowig, T Sparwasser, M Lochner
Eur. J. Immunol., 2019-03-10;0(0):.
Species: Mouse
Sample Types: Serum
-
Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice
Authors: AC Luissint, HC Williams, W Kim, S Flemming, V Azcutia, RS Hilgarth, MNO Leary, TL Denning, A Nusrat, CA Parkos
Mucosal Immunol, 2019-02-11;0(0):.
Species: Mouse
Sample Types: Peritoneal Exudate
-
PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium
Authors: P Saha, BS Yeoh, X Xiao, RM Golonka, V Singh, Y Wang, M Vijay-Kuma
Mucosal Immunol, 2019-02-01;0(0):.
Species: Mouse
Sample Types: Serum
-
Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection
Authors: D Emal, E Rampanelli, N Claessen, FJ Bemelman, JC Leemans, S Florquin, MC Dessing
Sci Rep, 2019-01-14;9(1):106.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality
Authors: U Kulkarni, RL Zemans, CA Smith, SC Wood, JC Deng, DR Goldstein
Mucosal Immunol, 2019-01-07;12(2):545-554.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
Authors: CC Campa, RL Silva, JP Margaria, T Pirali, MS Mattos, LR Kraemer, DC Reis, G Grosa, F Copperi, EM Dalmarco, RCP Lima-Júnio, S Aprile, V Sala, F Dal Bello, DS Prado, JC Alves-Filh, C Medana, GD Cassali, GC Tron, MM Teixeira, E Ciraolo, RC Russo, E Hirsch
Nat Commun, 2018-12-12;9(1):5232.
-
Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation
Authors: A de Araújo, FN da Fonseca, TM Rocha, LB de Freitas, EVO Araújo, DVT Wong, RCP Lima Júnio, LKAM Leal
Oxid Med Cell Longev, 2018-12-11;2018(0):8194849.
Species: Mouse
Sample Types: Tissue Homogenates
-
Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection
Authors: V Ciancarell, L Lembo-Fazi, I Paciello, AK Bruno, S Jaillon, S Berardi, M Barbagallo, S Meron-Suda, D Cohen, A Molinaro, G Rossi, C Garlanda, ML Bernardini
PLoS Pathog., 2018-12-07;14(12):e1007469.
Species: Mouse
Sample Types: Tissue Homogenates
-
Intermittent Hypoxia Activates Duration-Dependent Protective and Injurious Mechanisms in Mouse Lung Endothelial Cells
Authors: P Wohlrab, L Soto-Gonza, T Benesch, MP Winter, IM Lang, K Markstalle, V Tretter, KU Klein
Front Physiol, 2018-12-06;9(0):1754.
Species: Mouse
Sample Types: Cell Culture Supernates
-
CCR2 mediates increased susceptibility to post-H1N1 bacterial pneumonia by limiting dendritic cell induction of IL-17
Authors: SJ Gurczynski, N Nathani, HI Warheit-Ni, EM Hult, A Podsiad, J Deng, RL Zemans, U Bhan, BB Moore
Mucosal Immunol, 2018-11-29;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Bovine milk-derived extracellular vesicles enhance inflammation and promote M1 polarization following agricultural dust exposure in mice
Authors: TM Nordgren, AJ Heires, J Zempleni, BJ Swanson, C Wichman, DJ Romberger
J. Nutr. Biochem., 2018-11-03;64(0):110-120.
Species: Mouse
Sample Types: BALF
-
Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection
Authors: T Imai, T Matsumura, S Mayer-Lamb, CA Wells, E Ishikawa, SK Butcher, TC Barnett, MJ Walker, A Imamura, H Ishida, T Ikebe, T Miyamoto, M Ato, S Ohga, B Lepenies, NM van Sorge, S Yamasaki
Proc. Natl. Acad. Sci. U.S.A., 2018-10-23;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy
Authors: F Sato-Kanek, X Wang, S Yao, T Hosoya, FS Lao, K Messer, M Pu, NM Shukla, HB Cottam, M Chan, DA Carson, M Corr, T Hayashi
Biomed Res Int, 2018-10-10;2018(0):8091283.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling
Authors: C McWherter, YJ Choi, RL Serrano, SK Mahata, R Terkeltaub, R Liu-Bryan
Arthritis Res. Ther., 2018-09-06;20(1):204.
Species: Mouse
Sample Types: Air Pouch Exudate
-
Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells
Authors: DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson
Biol. Reprod., 2018-09-01;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects
Authors: X Xiao, P Saha, BS Yeoh, JA Hipp, V Singh, M Vijay-Kuma
J. Nutr. Biochem., 2018-08-21;62(0):28-34.
Species: Mouse
Sample Types: Serum
-
Extracellular ATP is a danger signal activating P2X7 receptor in a LPS mediated inflammation (ARDS/ALI)
Authors: S Cicko, TC Köhler, CK Ayata, T Müller, N Ehrat, A Meyer, M Hossfeld, A Zech, F Di Virgili, M Idzko
Oncotarget, 2018-07-17;9(55):30635-30648.
Species: Mouse
Sample Types: BALF
-
Repeated Allergen Exposure in A/J Mice Causes Steroid-Insensitive Asthma via a Defect in Glucocorticoid Receptor Bioavailability
Authors: MF Serra, AC Cotias, CRR Pão, JB Daleprane, PB Jurgilas, GC Couto, EA Anjos-Valo, RSB Cordeiro, VF Carvalho, PMR Silva, MA Martins
J. Immunol., 2018-06-18;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms
Authors: DT Skelly, ÉW Griffin, CL Murray, S Harney, C O'Boyle, E Hennessy, MA Dansereau, A Nazmi, L Tortorelli, JN Rawlins, DM Bannerman, C Cunningham
Mol. Psychiatry, 2018-06-06;24(10):1533-1548.
Species: Mouse
Sample Types: Plasma
-
Long-term dietary (n-3) polyunsaturated fatty acids show benefits to the lungs of Cftr F508del mice
Authors: C Portal, V Gouyer, R Léonard, MO Husson, F Gottrand, JL Desseyn
PLoS ONE, 2018-06-01;13(6):e0197808.
Species: Mouse
Sample Types: Tissue Homogenates
-
Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema
Authors: IK Sundar, K Rashid, J Gerloff, J Rangel-Mor, D Li, I Rahman
FASEB J., 2018-04-09;0(0):fj201701518R.
Species: Mouse
Sample Types: Tissue Homogenates
-
Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis
Authors: M Sakkou, P Chouvardas, L Ntari, A Prados, K Moreth, H Fuchs, V Gailus-Dur, M Hrabe de A, MC Denis, N Karagianni, G Kollias
JCI Insight, 2018-04-05;3(7):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence
Authors: A Sagiv, A Bar-Shai, N Levi, M Hatzav, L Zada, Y Ovadya, L Roitman, G Manella, O Regev, J Majewska, E Vadai, R Eilam, SW Feigelson, M Tsoory, M Tauc, R Alon, V Krizhanovs
Cell Rep, 2018-03-27;22(13):3468-3479.
Species: Mouse
Sample Types: BALF
-
Identification of periplakin as a major regulator of lung injury and repair in mice
Authors: V Besnard, R Dagher, T Madjer, A Joannes, M Jaillet, M Kolb, P Bonniaud, LA Murray, MA Sleeman, B Crestani
JCI Insight, 2018-03-08;3(5):.
Species: Mouse
Sample Types: BALF
-
Capturing the multifactorial nature of ARDS - "Two-hit" approach to model murine acute lung injury
Authors: S Hoegl, N Burns, M Angulo, D Francis, CM Osborne, TW Mills, MR Blackburn, HK Eltzschig, CU Vohwinkel
Physiol Rep, 2018-03-01;6(6):e13648.
Species: Mouse
Sample Types: BALF
-
The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis
Authors: J Fuchsloche, M Falk-Pauls, A Luzius, C Saggau, B Ruder, J Bolik, D Schmidt-Ar, A Linkermann, C Becker, P Rosenstiel, S Rose-John, D Adam
Oncotarget, 2018-02-05;9(16):12941-12958.
Species: Mouse
Sample Types: Serum
-
Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice
Authors: V Lamontain, T Schmid, D Weber-Stef, D Zeller, Z Jenei-Lanz, H Wajant, RH Straub, DN Männel
Cell. Mol. Immunol., 2018-01-29;0(0):.
Species: Mouse
Sample Types: Serum
-
Complement C5a Receptor 1 Exacerbates the Pathophysiology of N.�meningitidis Sepsis and Is a Potential Target for Disease Treatment
Authors: JB Herrmann, M Muensterma, L Strobel, A Schubert-U, TM Woodruff, SD Gray-Owen, A Klos, KO Johswich
MBio, 2018-01-23;9(1):.
Species: Mouse
Sample Types: Whole Blood
-
Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses
Authors: L Boutens, GJ Hooiveld, S Dhingra, RA Cramer, MG Netea, R Stienstra
Diabetologia, 2018-01-14;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection
Authors: EE Hornick, B Banoth, AM Miller, ZR Zacharias, N Jain, ME Wilson, KN Gibson-Cor, KL Legge, GA Bishop, FS Sutterwala, SL Cassel
J. Immunol., 2017-12-27;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression
Authors: MS Gresnigt, M Jaeger, RK Subbarao M, O Rasid, G Jouvion, C Fitting, WJG Melchers, TD Kanneganti, A Carvalho, O Ibrahim-Gr, FL van de Vee
Front Immunol, 2017-12-13;8(0):1777.
Species: Mouse
Sample Types: BALF
-
The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens
Authors: BJH Banaschews, B Baer, C Arsenault, T Jazey, EJA Veldhuizen, J Delport, T Gooyers, JF Lewis, HP Haagsman, RAW Veldhuizen, C Yamashita
Sci Rep, 2017-11-14;7(1):15545.
Species: Mouse
Sample Types: BALF
-
Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice
Authors: Y Kim, AG Wu, A Jaja-Chime, BL Graf, C Waterman, MP Verzi, I Raskin
PLoS ONE, 2017-09-18;12(9):e0184709.
Species: Mouse
Sample Types: Cell Culture Supernates
-
The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis
Authors: L Kosack, R Gawish, A Lercher, B Vilagos, A Hladik, K Lakovits, A Bhattachar, C Schliehe, I Mesteri, S Knapp, A Bergthaler
Sci Rep, 2017-09-12;7(1):11289.
Species: Mouse
Sample Types: Serum
-
Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis
Authors: K Watanabe, CA Gilchrist, MJ Uddin, SL Burgess, MM Abhyankar, SN Moonah, Z Noor, JR Donowitz, BN Schneider, T Arju, E Ahmed, M Kabir, M Alam, R Haque, P Pramoonjag, B Mehrad, WA Petri
PLoS Pathog., 2017-08-17;13(8):e1006513.
Species: Mouse
Sample Types: Tissue Homogenates
-
Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles
Authors: AL Jung, CE Herkt, C Schulz, K Bolte, K Seidel, N Scheller, A Sittka-Sta, W Bertrams, B Schmeck
Sci Rep, 2017-07-24;7(1):6301.
Species: Mouse
Sample Types: Cell Culture Supernates
-
?-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice
Authors: APL D'Almeida, MT Pacheco de, ÉT de Souza, D de Sá Cout, BT Ciambarell, CR Gomes, T Terroso, SS Guterres, AR Pohlmann, PM Silva, MA Martins, A Bernardi
Int J Nanomedicine, 2017-06-19;12(0):4479-4491.
Species: Mouse
Sample Types: Tissue Homogenates
-
NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity
Authors: G Stokman, L Kors, PJ Bakker, E Rampanelli, N Claessen, GJD Teske, L Butter, H van Andel, MA van den Be, PWB Larsen, MC Dessing, CJ Zuurbier, SE Girardin, S Florquin, JC Leemans
J. Exp. Med., 2017-06-16;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection
Authors: JA Espinoza, MA León, PF Céspedes, RS Gómez, G Canedo-Mar, SA Riquelme, FJ Salazar-Ec, P Blancou, T Simon, I Anegon, MK Lay, PA González, CA Riedel, SM Bueno, AM Kalergis
J. Immunol., 2017-05-31;0(0):.
Species: Mouse
Sample Types: BALF
-
Interleukin 17A Promotes Lymphocytes Adhesion and Induces CCL2 and CXCL1 Release from Brain Endothelial Cells
Authors: DW Wojkowska, P Szpakowski, A Glabinski
Int J Mol Sci, 2017-05-08;18(5):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Fetuin-A aggravates lipotoxicity in podocytes via interleukin-1 signaling
Authors: JM Orellana, K Kampe, F Schulze, J Sieber, AW Jehle
Physiol Rep, 2017-05-01;5(10):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1
Authors: E Jentho, M Bodden, C Schulz, AL Jung, K Seidel, B Schmeck, W Bertrams
PLoS ONE, 2017-04-26;12(4):e0176204.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection
Authors: CT Molloy, JS Andonian, HM Seltzer, MC Procario, ME Watson, JB Weinberg
Virology, 2017-04-11;507(0):64-74.
Species: Mouse
Sample Types: BALF
-
Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis
Authors: MC Souza, DM Fonseca, A Kanashiro, L Benevides, TS Medina, MS Dias, WA Andrade, G Bonfá, MAB Silva, A Gozzi, MC Borges, RT Gazzinelli, JC Alves-Filh, FQ Cunha, JS Silva
Front Cell Infect Microbiol, 2017-04-07;7(0):116.
Species: Mouse
Sample Types: Serum
-
Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance
Authors: KL Chan, TH Tam, P Boroumand, D Prescott, SR Costford, NK Escalante, N Fine, Y Tu, SJ Robertson, D Prabaharan, Z Liu, PJ Bilan, MW Salter, M Glogauer, SE Girardin, DJ Philpott, A Klip
Cell Rep, 2017-03-07;18(10):2415-2426.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses
Authors: P Martin, G Palmer, E Rodriguez, CA Seemayer, J Palomo, D Talabot-Ay, C Gabay
J. Immunol, 2017-02-24;0(0):.
Species: Mouse
Sample Types: Serum
-
Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory FADDosome Complex upon TRAIL Stimulation
Authors: CM Henry, SJ Martin
Mol. Cell, 2017-02-16;65(4):715-729.e5.
Species: Mouse
Sample Types: Cell Culture Supernates
-
The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2
Authors: T Hartwig, A Montinaro, S von Karste, A Sevko, S Surinova, A Chakravart, L Taraborrel, P Draber, E Lafont, F Arce Varga, MA El-Bahrawy, SA Quezada, H Walczak
Mol. Cell, 2017-02-16;65(4):730-742.e5.
Species: Mouse
Sample Types: Tissue Homogenates
-
Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection
Authors: R Th„nert, O Goldmann, A Beineke, E Medina
Nat Commun, 2017-02-03;8(0):14268.
Species: Mouse
Sample Types: Tissue Homogenates
-
Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung
Authors: Ismé M de Kleer
Immunity, 2016-12-06;45(6):1285-1298.
Species: Mouse
Sample Types: Tissue Homogenates
-
The Anti-inflammatory Effect of Alpha-1 Antitrypsin in Rhinovirus-infected Human Airway Epithelial Cells
Authors: D Jiang, R Berman, Q Wu, C Stevenson, HW Chu
J Clin Cell Immunol, 2016-12-05;7(6):.
Species: Mouse
Sample Types: BALF
-
Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation
Authors: Jand Venes R Medeiros
Chem. Biol. Interact., 2016-11-09;260(0):129-140.
Species: Mouse
Sample Types: Tissue Homogenates
-
Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice
Authors: Nigel Mackman
J Innate Immun, 2016-11-08;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma
JCI Insight, 2016-11-03;1(18):e88811.
Species: Mouse
Sample Types: BALF
-
The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition
PLoS ONE, 2016-10-31;11(10):e0165361.
Species: Mouse
Sample Types: BALF
-
Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function
Proc Natl Acad Sci USA, 2016-09-26;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis
PLoS Pathog., 2016-09-22;12(9):e1005855.
Species: Mouse
Sample Types: Tissue Homogenates
-
Poly-N-acetyl glucosamine production by Staphylococcus epidermidis cells increases their in vivo pro-inflammatory effect
Infect Immun, 2016-09-19;0(0):.
Species: Mouse
Sample Types: Tissue Secretion
-
Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1? Stabilization during Pneumonia
MBio, 2016-09-13;7(5):.
Species: Mouse
Sample Types: Tissue Homogenates
-
NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury
J Leukoc Biol, 2016-09-06;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
-
Glucosylation drives the innate inflammatory response to Clostridium difficile Toxin A
Authors: Carrie A Cowardin
Infect Immun, 2016-07-21;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI)
PLoS ONE, 2016-07-20;11(7):e0159417.
Species: Mouse
Sample Types: BALF
-
Contribution of the Ade Resistance-Nodulation-Cell Division-Type Efflux Pumps to Fitness and Pathogenesis of Acinetobacter baumannii
Authors: Eun-Jeong Yoon
MBio, 2016-05-31;7(3):.
Species: Mouse
Sample Types: BALF
-
Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor
Sci Rep, 2016-05-24;6(0):26490.
Species: Mouse
Sample Types: Tissue Homogenates
-
Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice
PLoS ONE, 2016-05-19;11(5):e0155784.
Species: Mouse
Sample Types: Serum
-
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
Sci Rep, 2016-05-17;6(0):26071.
Species: Mouse
Sample Types: Cell Culture Supernates
-
C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-?B Activation in Neutrophils
J Immunol, 2016-01-22;196(5):2319-26.
Species: Mouse
Sample Types: BALF
-
Inducible Expression of CXCL1 within the Central Nervous System Amplifies Viral-Induced Demyelination.
Authors: Marro B, Grist J, Lane T
J Immunol, 2016-01-15;196(4):1855-64.
Species: Mouse
Sample Types: Cell Culture Supernates
-
C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus.
Authors: Carlucci F, Ishaque A, Ling G, Szajna M, Sandison A, Donatien P, Cook H, Botto M
J Immunol, 2016-01-15;196(4):1488-94.
Species: Mouse
Sample Types: Serum
-
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
Authors: Brown A, Murphy A, Lalor S, Leech J, O'Keeffe K, Mac Aogain M, O'Halloran D, Lacey K, Tavakol M, Hearnden C, Fitzgerald-Hughes D, Humphreys H, Fennell J, van Wamel W, Foster T, Geoghegan J, Lavelle E, Rogers T, McLoughlin R
PLoS Pathog, 2015-11-05;11(11):e1005226.
Species: Mouse
Sample Types: Cell Culture Supernates
-
C1q Deficiency Promotes Pulmonary Vascular Inflammation and Enhances the Susceptibility of the Lung Endothelium to Injury.
Authors: Shah D, Romero F, Zhu Y, Duong M, Sun J, Walsh K, Summer R
J Biol Chem, 2015-10-20;290(49):29642-51.
Species: Mouse
Sample Types: BALF
-
Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFkappaB Activity in Macrophages.
Authors: Hamers A, van Dam L, Teixeira Duarte J, Vos M, Marinkovic G, van Tiel C, Meijer S, van Stalborch A, Huveneers S, Te Velde A, de Jonge W, de Vries C
PLoS ONE, 2015-08-04;10(8):e0133598.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury.
Authors: Hoegl S, Brodsky K, Blackburn M, Karmouty-Quintana H, Zwissler B, Eltzschig H
J Immunol, 2015-07-17;195(4):1815-24.
Species: Mouse
Sample Types: BALF
-
Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir.
Authors: Hong E, Song J, Shim A, Lee B, Kwon B, Song H, Kim Y, Chang S, Jeong H, Kim J, Seo S, Kim H, Kwon Y, Ko H
PLoS ONE, 2015-06-22;10(6):e0131089.
Species: Mouse
Sample Types: Tissue Homogenates
-
Poly(inosinic-cytidylic) acid-triggered exacerbation of experimental asthma depends on IL-17A produced by NK cells.
Authors: Lunding L, Webering S, Vock C, Behrends J, Wagner C, Holscher C, Fehrenbach H, Wegmann M
J Immunol, 2015-05-13;194(12):5615-25.
Species: Mouse
Sample Types: BALF
-
Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection.
Authors: Segueni N, Vigne S, Palmer G, Bourigault M, Olleros M, Vesin D, Garcia I, Ryffel B, Quesniaux V, Gabay C
PLoS ONE, 2015-05-07;10(5):e0126058.
Species: Mouse
Sample Types: Tissue Homogenates
-
De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes.
Authors: Alissafi T, Hatzioannou A, Ioannou M, Sparwasser T, Grun J, Grutzkau A, Verginis P
J Immunol, 2015-05-06;194(12):5812-24.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors.
Authors: Dau T, Sarker R, Yildirim A, Eickelberg O, Jenne D
Nat Commun, 2015-04-10;6(0):6722.
Species: Mouse
Sample Types: BALF
-
Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema.
Authors: Lunghi B, De Cunto G, Cavarra E, Fineschi S, Bartalesi B, Lungarella G, Lucattelli M
PLoS ONE, 2015-03-19;10(3):e0119797.
Species: Mouse
Sample Types: BALF
-
Mast cells play an important role in chlamydia pneumoniae lung infection by facilitating immune cell recruitment into the airway.
Authors: Chiba N, Shimada K, Chen S, Jones H, Alsabeh R, Slepenkin A, Peterson E, Crother T, Arditi M
J Immunol, 2015-03-09;194(8):3840-51.
Species: Mouse
Sample Types: BALF
-
Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.
Authors: Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell M, Saijo S, Mostowy S, Shaunak S, Armstrong-James D
EMBO Mol Med, 2015-03-01;7(3):240-58.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production.
Authors: Kearney C, Cullen S, Tynan G, Henry C, Clancy D, Lavelle E, Martin S
Cell Death Differ, 2015-01-23;22(8):1313-27.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice.
Authors: Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, Hanisch U, Triebel J, Bollheimer L, Sieber C, Nau R
J Neuroinflammation, 2015-01-07;12(0):208.
Species: Mouse
Sample Types: Tissue Homogenates
-
Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity.
Authors: Barra, Nicole G, Palanivel, Rengasam, Denou, Emmanuel, Chew, Marianne, Gillgrass, Amy, Walker, Tina D, Kong, Josh, Richards, Carl D, Jordana, Manel, Collins, Stephen, Trigatti, Bernardo, Holloway, Alison C, Raha, Sandeep, Steinberg, Gregory, Ashkar, Ali A
PLoS ONE, 2014-12-17;9(12):e114799.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection.
PLoS ONE, 2014-12-12;9(12):e114884.
Species: Mouse
Sample Types: Tissue Homogenates
-
Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection.
Authors: Zhao Y, Olonisakin T, Xiong Z, Hulver M, Sayeed S, Yu M, Gregory A, Kochman E, Chen B, Mallampalli R, Sun M, Silverstein R, Stolz D, Shapiro S, Ray A, Ray P, Lee J
Mucosal Immunol, 2014-12-10;8(4):896-905.
Species: Mouse
Sample Types: Tissue Homogenates
-
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.
Authors: Schliehe C, Flynn E, Vilagos B, Richson U, Swaminathan S, Bosnjak B, Bauer L, Kandasamy R, Griesshammer I, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett A, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein M, Symer D, Aderem A, Bergthaler A
Nat Immunol, 2014-11-24;16(1):67-74.
Species: Mouse
Sample Types: BALF
-
Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation.
Authors: Slocum C, Coats S, Hua N, Kramer C, Papadopoulos G, Weinberg E, Gudino C, Hamilton J, Darveau R, Genco C
PLoS Pathog, 2014-07-10;10(7):e1004215.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2alpha.
Authors: Grabiner M, Fu Z, Wu T, Barry K, Schwarzer C, Machen T
J Immunol, 2014-07-02;193(3):1459-67.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections.
Authors: Redlich S, Ribes S, Schutze S, Nau R
J Neuroinflammation, 2014-06-14;11(0):108.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Development and characterization of a long-term murine model of Streptococcus pneumoniae infection of the lower airways.
Authors: Haste L, Hulland K, Bolton S, Yesilkaya H, McKechnie K, Andrew P
Infect Immun, 2014-05-27;82(8):3289-98.
Species: Mouse
Sample Types: BALF
-
A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia.
Authors: De Filippo K, Neill D, Mathies M, Bangert M, McNeill E, Kadioglu A, Hogg N
FASEB J, 2014-04-28;28(8):3600-8.
Species: Mouse
Sample Types: Tissue Homogenates
-
IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice.
Authors: Spann K, Loh Z, Lynch J, Ullah A, Zhang V, Baturcam E, Werder R, Khajornjiraphan N, Rudd P, Loo Y, Suhrbier A, Gale M, Upham J, Phipps S
Am J Pathol, 2014-04-13;184(6):1795-806.
Species: Mouse
Sample Types: Tissue Homogenates
-
Vitamin d deficiency reduces the immune response, phagocytosis rate, and intracellular killing rate of microglial cells.
Authors: Djukic M, Onken M, Schutze S, Redlich S, Gotz A, Hanisch U, Bertsch T, Ribes S, Hanenberg A, Schneider S, Bollheimer C, Sieber C, Nau R
Infect Immun, 2014-03-31;82(6):2585-94.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Protease-activated receptor-2 activation contributes to house dust mite-induced IgE responses in mice.
Authors: Post, Sijranke, Heijink, Irene H, Petersen, Arjen H, de Bruin, Harold G, van Oosterhout, Antoon J, Nawijn, Martijn
PLoS ONE, 2014-03-20;9(3):e91206.
Species: Mouse
Sample Types: Tissue Homogenates
-
Toll-like receptor 9 deficiency protects mice against Pseudomonas aeruginosa lung infection.
Authors: Benmohamed F, Medina M, Wu Y, Maschalidi S, Jouvion G, Guillemot L, Chignard M, Manoury B, Touqui L
PLoS ONE, 2014-03-04;9(3):e90466.
Species: Mouse
Sample Types: BALF
-
Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw.
Authors: Calil I, Zarpelon A, Guerrero A, Alves-Filho J, Ferreira S, Cunha F, Cunha T, Verri W
PLoS ONE, 2014-03-03;9(3):e90013.
Species: Mouse
Sample Types: Tissue Homogenates
-
MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.
Authors: Ballak D, van Essen P, van Diepen J, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack C, Netea M, Joosten L, Stienstra R
PLoS ONE, 2014-02-24;9(2):e89615.
Species: Mouse
Sample Types: Plasma
-
Induction of type I interferon signaling determines the relative pathogenicity of Staphylococcus aureus strains.
Authors: Parker D, Planet P, Soong G, Narechania A, Prince A
PLoS Pathog, 2014-02-20;10(2):e1003951.
Species: Mouse
Sample Types: BALF
-
A TNF-alpha-CCL20-CCR6 axis regulates Nod1-induced B cell responses.
Authors: Paradis M, Mindt B, Duerr C, Rojas O, Ng D, Boulianne B, McCarthy D, Yu M, Summers deLuca L, Ward L, Waldron J, Philpott D, Gommerman J, Fritz J
J Immunol, 2014-02-17;192(6):2787-99.
Species: Mouse
Sample Types: Serum
-
Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection.
Authors: Blanchet C, Jouvion G, Fitting C, Cavaillon J, Adib-Conquy M
PLoS ONE, 2014-01-31;9(1):e87927.
Species: Mouse
Sample Types: BALF
-
Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.
Authors: Dreymueller D, Martin C, Schumacher J, Groth E, Boehm J, Reiss L, Uhlig S, Ludwig A
J Immunol, 2013-12-16;192(2):722-31.
Species: Mouse
Sample Types: Cell Culture Supernates
-
The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice.
Authors: Hansen, Michelle, Chen, Hui, Jones, Jessica, Langenbach, Shenna Y, Vlahos, Ross, Gualano, Rosa C, Morris, Margaret, Anderson, Gary P
PLoS ONE, 2013-11-19;8(11):e80471.
Species: Mouse
Sample Types: Tissue Homogenates
-
alpha1-Antitrypsin promotes SPLUNC1-mediated lung defense against Pseudomonas aeruginosa infection in mice.
Authors: Jiang D, Persinger R, Wu Q, Gross A, Chu H
Respir Res, 2013-11-09;14(0):122.
Species: Mouse
Sample Types: BALF
-
Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides.
Authors: Moseman, Annie Pa, Moseman, E Ashley, Schworer, Stephen, Smirnova, Irina, Volkova, Tatyana, von Andrian, Ulrich, Poltorak, Alexande
J Immunol, 2013-11-01;191(11):5615-24.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Limited role of nuclear receptor Nur77 in Escherichia coli-induced peritonitis.
Authors: Hamers A, Uleman S, van Tiel C, Kruijswijk D, van Stalborch A, Huveneers S, de Vries C, van 't Veer C
Infect Immun, 2013-10-28;82(1):253-64.
Species: Mouse
Sample Types: Plasma
-
Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway.
Authors: Hwang J, Sundar I, Yao H, Sellix M, Rahman I
FASEB J, 2013-09-11;28(1):176-94.
Species: Mouse
Sample Types: Tissue Homogenates
-
Deficiency of C5L2 increases macrophage infiltration and alters adipose tissue function in mice.
Authors: Gauvreau D, Gupta A, Fisette A, Tom F, Cianflone K
PLoS ONE, 2013-04-22;8(4):e60795.
Species: Mouse
Sample Types: Plasma
-
IRAK-M mediates Toll-like receptor/IL-1R-induced NFkappaB activation and cytokine production.
Authors: Zhou H, Yu M, Fukuda K, Im J, Yao P, Cui W, Bulek K, Zepp J, Wan Y, Kim T, Yin W, Ma V, Thomas J, Gu J, Wang J, DiCorleto P, Fox P, Qin J, Li X
EMBO J, 2013-02-01;32(4):583-96.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation.
PLoS ONE, 2012-09-05;7(9):e44328.
Species: Mouse
Sample Types: Serum
-
Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, Is crucial for murine asthma.
Authors: Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua D, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide D, Matsumoto K, Nakae S
J Immunol, 2012-08-31;189(7):3641-52.
Species: Mouse
Sample Types: BALF
-
IL-22 signaling contributes to West Nile encephalitis pathogenesis.
Authors: Wang, Penghua, Bai, Fengwei, Zenewicz, Lauren A, Dai, Jianfeng, Gate, David, Cheng, Gong, Yang, Long, Qian, Feng, Yuan, Xiaoling, Montgomery, Ruth R, Flavell, Richard, Town, Terrence, Fikrig, Erol
PLoS ONE, 2012-08-28;7(8):e44153.
Species: Mouse
Sample Types: Plasma
-
Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
J. Exp. Med., 2012-07-16;209(8):1505-17.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis.
J. Immunol., 2012-07-11;189(4):1911-9.
Species: Mouse
Sample Types: Serum
-
Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis.
Authors: Serezani CH, Kane S, Collins L
J. Immunol., 2012-06-13;189(2):906-15.
Species: Mouse
Sample Types: BALF
-
The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.
Kidney Int, 2012-05-23;82(7):759-70.
Species: Mouse
Sample Types: Serum
-
Effect of secretin on preadipocyte, differentiating and mature adipocyte functions.
Authors: Miegueu P, Cianflone K, Richard D, St-Pierre D
Int J Obes (Lond), 2012-05-08;37(3):366-74.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung.
Authors: Habibzay, M, Saldana, J I, Goulding, J, Lloyd, C M, Hussell, T
Mucosal Immunol, 2012-05-02;5(5):524-34.
Species: Mouse
Sample Types: BALF
-
The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems.
Authors: Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, Fernandez C
PLoS ONE, 2012-02-29;7(2):e32125.
Species: Mouse
Sample Types: Cell Culture Supernates
-
IL-1alpha/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.
Authors: Botelho F, Bauer C, Finch D, Nikota J, Zavitz C, Kelly A, Lambert K, Piper S, Foster M, Goldring J, Wedzicha J, Bassett J, Bramson J, Iwakura Y, Sleeman M, Kolbeck R, Coyle A, Humbles A, Stampfli M
PLoS ONE, 2011-12-06;6(12):e28457.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection.
Authors: Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C
Infect. Immun., 2011-10-24;80(1):100-9.
Species: Mouse
Sample Types: Serum
-
Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia.
Authors: Steinwede K, Tempelhof O, Bolte K, Maus R, Bohling J, Ueberberg B, Langer F, Christman JW, Paton JC, Ask K, Maharaj S, Kolb M, Gauldie J, Welte T, Maus UA
J. Immunol., 2011-10-14;187(10):5346-56.
Species: Mouse
Sample Types: BALF
-
Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein.
Authors: Le Goffic R, Leymarie O, Chevalier C, Rebours E, Da Costa B, Vidic J, Descamps D, Sallenave JM, Rauch M, Samson M, Delmas B
PLoS Pathog., 2011-08-25;7(8):e1002202.
Species: Mouse
Sample Types: BALF
-
Leukocyte ADAM17 Regulates Acute Pulmonary Inflammation.
Authors: Arndt PG, Strahan B, Wang Y, Long C, Horiuchi K, Walcheck B
PLoS ONE, 2011-05-16;6(5):e19938.
Species: Mouse
Sample Types: BALF
-
Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance.
Authors: Breslow JM, Meissler JJ, Hartzell RR
Infect. Immun., 2011-05-16;79(8):3317-27.
Species: Mouse
Sample Types: Tissue Secretion
-
Lung-targeted overexpression of the NF-kappaB member RelB inhibits cigarette smoke-induced inflammation.
Authors: McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP
Am. J. Pathol., 2011-05-05;179(1):125-33.
Species: Mouse
Sample Types: BALF
-
The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa.
Authors: Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, Valentino S, Mantero S, Nebuloni M, Mantovani A, Bragonzi A, Garlanda C
J. Immunol., 2011-03-25;186(9):5425-34.
Species: Mouse
Sample Types: Tissue Homogenates
-
Chemokine binding protein M3 of murine gammaherpesvirus 68 modulates the host response to infection in a natural host.
Authors: Hughes DJ, Kipar A, Leeming GH, Bennett E, Howarth D, Cummerson JA, Papoula-Pereira R, Flanagan BF, Sample JT, Stewart JP
PLoS Pathog., 2011-03-17;7(3):e1001321.
Species: Mouse
Sample Types: Tissue Homogenates
-
A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation.
Authors: Bourgeois EA, Levescot A, Diem S, Chauvineau A, Berges H, Milpied P, Lehuen A, Damotte D, Gombert JM, Schneider E, Girard JP, Gourdy P, Herbelin A
Eur. J. Immunol., 2011-01-11;41(2):299-305.
Species: Mouse
Sample Types: BALF
-
Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia.
Authors: Van Den Boogaard FE, Brands X, Schultz MJ, Levi M, Roelofs JJ, Van 't Veer C, van der Poll T
J. Thromb. Haemost., 2011-01-01;9(1):122-32.
Species: Mouse
Sample Types: BALF
-
Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.
Authors: Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffe E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM
J. Leukoc. Biol., 2010-11-02;89(2):269-82.
Species: Mouse
Sample Types: Tissue Homogenates
-
Toll-like receptor 4 mediates the response of epithelial and stromal cells to lipopolysaccharide in the endometrium.
Authors: Sheldon IM, Roberts MH
PLoS ONE, 2010-09-22;5(9):e12906.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice.
Authors: Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C
J. Immunol., 2010-07-16;185(0):2516-24.
Species: Mouse
Sample Types: Serum
-
Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.
Authors: van Neerven S, Regen T, Wolf D, Nemes A, Johann S, Beyer C, Hanisch UK, Mey J
J. Neurochem., 2010-06-16;114(5):1511-26.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice.
Authors: von Vietinghoff S, Asagiri M, Azar D
J. Immunol., 2010-06-02;185(1):670-8.
Species: Mouse
Sample Types: Plasma
-
Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis.
Authors: van Zoelen MA, Achouiti A, Schmidt AM, Yang H, Florquin S, Tracey KJ, van der Poll T
Crit. Care Med., 2010-06-01;38(6):1414-22.
Species: Mouse
Sample Types: Peritoneal Fluid
-
Trimer stability of YadA is critical for virulence of Yersinia enterocolitica.
Authors: Schutz M, Weiss EM, Schindler M, Hallstrom T, Zipfel PF, Linke D, Autenrieth IB
Infect. Immun., 2010-03-22;78(6):2677-90.
Species: Mouse
Sample Types: Serum
-
Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity.
Authors: Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A
J. Immunol., 2010-01-20;184(4):2076-85.
Species: Mouse
Sample Types: Cell Culture Supernates
-
CCR7 modulates pulmonary and lymph node inflammatory responses in cigarette smoke-exposed mice.
Authors: Demoor T, Bracke KR, Vermaelen KY, Dupont L, Joos GF, Brusselle GG
J. Immunol., 2009-12-15;183(12):8186-94.
Species: Mouse
Sample Types: BALF
-
IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema.
Authors: Couillin I, Vasseur V, Charron S, Gasse P, Tavernier M, Guillet J, Lagente V, Fick L, Jacobs M, Coelho FR, Moser R, Ryffel B
J. Immunol., 2009-12-15;183(12):8195-202.
Species: Mouse
Sample Types: BALF
-
Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice.
Authors: Zhu M, Hug C, Kasahara DI
Am. J. Respir. Cell Mol. Biol., 2009-11-13;43(4):487-97.
Species: Mouse
Sample Types: BALF
-
Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis.
Authors: van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, Heeringa P
Clin. Exp. Immunol., 2009-10-01;158(1):143-53.
Species: Mouse
Sample Types: Tissue Homogenates
-
Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation.
Authors: Zhou H, Andonegui G, Wong CH, Kubes P
J. Immunol., 2009-09-28;183(8):5244-50.
Species: Mouse
Sample Types: Plasma
-
TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia.
Authors: Lagler H, Sharif O, Haslinger I, Matt U, Stich K, Furtner T, Doninger B, Schmid K, Gattringer R, de Vos AF, Knapp S
J. Immunol., 2009-07-13;183(3):2027-36.
Species: Mouse
Sample Types: Tissue Homogenates
-
The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice.
Authors: Souza DG, Amaral FA, Fagundes CT, Coelho FM, Arantes RM, Sousa LP, Matzuk MM, Garlanda C, Mantovani A, Dias AA, Teixeira MM
Am. J. Pathol., 2009-03-12;174(4):1309-18.
Species: Mouse
Sample Types: Serum
-
Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment.
Authors: Wilkinson TS, Dhaliwal K, Hamilton TW, Lipka AF, Farrell L, Davidson DJ, Duffin R, Morris AC, Haslett C, Govan JR, Gregory CD, Sallenave JM, Simpson AJ
Am. J. Pathol., 2009-03-05;174(4):1338-46.
Species: Mouse
Sample Types: BALF
-
Matrix metalloproteinase-9 deficiency worsens lung injury in a model of bronchopulmonary dysplasia.
Authors: Lukkarinen H, Hogmalm A, Lappalainen U, Bry K
Am. J. Respir. Cell Mol. Biol., 2008-12-18;41(1):59-68.
Species: Mouse
Sample Types: Tissue Homogenates
-
Methylprednisolone improves lung mechanics and reduces the inflammatory response in pulmonary but not in extrapulmonary mild acute lung injury in mice.
Authors: Leite-Junior JH, Garcia CS, Souza-Fernandes AB, Silva PL, Ornellas DS, Larangeira AP, Castro-Faria-Neto HC, Morales MM, Negri EM, Capelozzi VL, Zin WA, Pelosi P, Bozza PT, Rocco PR
Crit. Care Med., 2008-09-01;36(9):2621-8.
Species: Mouse
Sample Types: BALF
-
The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature.
Authors: Coelho FM, Pinho V, Amaral FA, Sachs D, Costa VV, Rodrigues DH, Vieira AT, Silva TA, Souza DG, Bertini R, Teixeira AL, Teixeira MM
Arthritis Rheum., 2008-08-01;58(8):2329-37.
Species: Mouse
Sample Types: Tissue Homogenates
-
MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2.
Authors: Tarabishy AB, Aldabagh B, Sun Y, Imamura Y, Mukherjee PK, Lass JH, Ghannoum MA, Pearlman E
J. Immunol., 2008-07-01;181(1):593-600.
Species: Mouse
Sample Types: Tissue Homogenates
-
Adenosine receptors in regulation of dendritic cell differentiation and function.
Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
Blood, 2008-06-17;112(5):1822-31.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13.
Authors: Williams AS, Nath P, Leung SY, Khorasani N, McKenzie AN, Adcock IM, Chung KF
Eur. Respir. J., 2008-04-16;32(3):571-8.
Species: Mouse
Sample Types: BALF
-
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues.
Authors: Cardona AE, Sasse ME, Liu L, Cardona SM, Mizutani M, Savarin C, Hu T, Ransohoff RM
Blood, 2008-03-17;112(2):256-63.
Species: Mouse
Sample Types: Tissue Homogenates
-
An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition.
Authors: Nomellini V, Faunce DE, Gomez CR, Kovacs EJ
J. Leukoc. Biol., 2008-03-13;83(6):1493-501.
Species: Mouse
Sample Types: Tissue Homogenates
-
Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent.
Authors: Doz E, Noulin N, Boichot E, Guenon I, Fick L, Le Bert M, Lagente V, Ryffel B, Schnyder B, Quesniaux VF, Couillin I
J. Immunol., 2008-01-15;180(2):1169-78.
Species: Mouse
Sample Types: BALF
-
IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice.
Authors: Smith E, Zarbock A, Stark MA, Burcin TL, Bruce AC, Foley P, Ley K
J. Immunol., 2007-12-15;179(12):8274-9.
Species: Mouse
Sample Types: Serum
-
Deletion of TLR5 results in spontaneous colitis in mice.
Authors: Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT
J. Clin. Invest., 2007-12-01;117(12):3909-21.
Species: Mouse
Sample Types: Serum
-
IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.
Authors: Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I
J. Clin. Invest., 2007-12-01;117(12):3786-99.
Species: Mouse
Sample Types: BALF
-
Involvement of vitronectin in lipopolysaccaride-induced acute lung injury.
Authors: Tsuruta Y, Park YJ, Siegal GP, Liu G, Abraham E
J. Immunol., 2007-11-15;179(10):7079-86.
Species: Mouse
Sample Types: Tissue Homogenates
-
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Authors: Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J
Blood, 2007-11-07;111(3):1021-8.
Species: Mouse
Sample Types: Air Pouch Exudate
-
Clara cells impact the pulmonary innate immune response to LPS.
Authors: Elizur A, Adair-Kirk TL, Kelley DG, Griffin GL, deMello DE, Senior RM
Am. J. Physiol. Lung Cell Mol. Physiol., 2007-05-25;293(2):L383-92.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
Immunity, 2007-04-12;26(4):445-59.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Role of Toll-like receptor 2 in recognition of Legionella pneumophila in a murine pneumonia model.
Authors: Fuse ET, Tateda K, Kikuchi Y, Matsumoto T, Gondaira F, Azuma A, Kudoh S, Standiford TJ, Yamaguchi K
J. Med. Microbiol., 2007-03-01;56(0):305-12.
Species: Mouse
Sample Types: Tissue Homogenates
-
Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum.
Authors: Witowski J, Ksiazek K, Warnecke C, Kuzlan M, Korybalska K, Tayama H, Wisniewska-Elnur J, Pawlaczyk K, Trominska J, Breborowicz A, Jorres A
Kidney Int., 2007-01-17;71(6):514-25.
Species: Mouse
Sample Types: Peritoneal Lavage Fluid
-
Interleukin-17 is a negative regulator of established allergic asthma.
Authors: Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B
J. Exp. Med., 2006-11-13;203(12):2715-25.
Species: Mouse
Sample Types: Tissue Homogenates
-
Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals.
Authors: Scott P, Ma H, Viriyakosol S, Terkeltaub R, Liu-Bryan R
J. Immunol., 2006-11-01;177(9):6370-8.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection.
Authors: Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS
Am. J. Pathol., 2006-11-01;169(5):1686-700.
Species: Mouse
Sample Types: Serum
-
Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae.
Authors: Rodriguez N, Wantia N, Fend F, Durr S, Wagner H, Miethke T
Eur. J. Immunol., 2006-05-01;36(5):1145-55.
Species: Mouse
Sample Types: Tissue Homogenates
-
Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis.
Authors: Alves-Filho JC, de Freitas A, Russo M, Cunha FQ
Crit. Care Med., 2006-02-01;34(2):461-70.
Species: Mouse
Sample Types: Tissue Homogenates
-
Increased pulmonary responses to acute ozone exposure in obese db/db mice.
Authors: Lu FL, Johnston RA, Flynt L, Theman TA, Terry RD, Schwartzman IN, Lee A, Shore SA
Am. J. Physiol. Lung Cell Mol. Physiol., 2005-12-22;290(5):L856-65.
Species: Mouse
Sample Types: Serum
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Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin.
Authors: Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, Maillet I, Robert T, Vargaftig BB, Ryffel B, Couillin I
J. Immunol., 2005-11-15;175(10):6861-9.
Species: Mouse
Sample Types: BALF
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An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia.
Authors: Hajjar AM, Harowicz H, Liggitt HD, Fink PJ, Wilson CB, Skerrett SJ
Am. J. Respir. Cell Mol. Biol., 2005-08-11;33(5):470-5.
Species: Mouse
Sample Types: Tissue Homogenates
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Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice.
Authors: Kim KH, Burkhart K, Chen P, Frevert CW, Randolph-Habecker J, Hackman RC, Soloway PD, Madtes DK
Am. J. Respir. Cell Mol. Biol., 2005-06-09;33(3):271-9.
Species: Mouse
Sample Types: BALF
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Anti-inflammatory activity in the aqueous crude extract of the leaves of Nidularium procerum: A bromeliaceae from the Brazilian coastal rain forest.
Authors: Amendoeira FC, Frutuoso VS, Zanon C, Chedier LM, Figueiredo MR, Kaplan MA, Bandeira-Melo C, Bozza PT, Castro-Faria-Neto HC
Biol. Pharm. Bull., 2005-06-01;28(6):1010-5.
Species: Mouse
Sample Types: Pleural Fluid
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Impaired inflammatory angiogenesis, but not leukocyte influx, in mice lacking TNFR1.
Authors: Barcelos LS, Talvani A, Teixeira AS, Vieira LQ, Cassali GD, Andrade SP, Teixeira MM
J. Leukoc. Biol., 2005-05-13;78(2):352-8.
Species: Mouse
Sample Types: Complex Sample Type
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Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo.
Authors: Allen L, Dockrell DH, Pattery T, Lee DG, Cornelis P, Hellewell PG, Whyte MK
J. Immunol., 2005-03-15;174(6):3643-9.
Species: Mouse
Sample Types: BALF
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Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance.
Authors: Yarovinsky TO, Powers LS, Butler NS, Bradford MA, Monick MM, Hunninghake GW
J. Immunol., 2003-09-01;171(5):2453-60.
Species: Mouse
Sample Types: Serum
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The kit worked great. We used it to test the serum level of KC from mice infected by bacterial pathogen. It showed significant induction of KC in infected mice.
When protocol is followed as described, standard curve is good.
Result has been published in 10.1371/journal.pone.0058258
easy to use, consistent results
Murine bone marrow derived dendritic cells were propagated in bento(a)pyrene and exposed to heat killed pseudomonas aeruginosa (HKPA) for 24 hours. Levels of KC were assessed in the tissue cultures supernatants by ELISA. n=5, triplicate wells. * p < 0.05