Mouse MMP-3 Antibody Summary
Tyr18-Cys477
Accession # P28862
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MMP-3
Matrix metalloproteinases are a family of zinc and calcium-dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-3 (stromelysin-1) can degrade a broad range of substrates including collagen alpha -chains, aggrecan, laminin, fibronectin, elastin, casein, alpha -1 antitrypsin, myelin basic protein, IL-1 beta, IGFBP-3, pro-MMP-1, pro-MMP-7, pro-MMP-8, pro-MMP-9 and pro-MMP-13. MMP-3 does not cleave the triple helical region of interstitial collagens, a characteristic which distinguishes the stromelysins from the collagenases. The MMP-3 substrate repertoire extends beyond extracellular matrix proteins and implicates MMP-3 in roles other than direct tissue remodeling, for instance, enzyme cascades and cytokine regulation. MMP-3 is expressed by fibroblasts, chrondrocytes, osteoblasts, endothelial cells, smooth muscle cells and macrophages. Structurally, MMP-3 may be divided into several distinct domains, a pro-domain which is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin-like) domain.
Product Datasheets
Citations for Mouse MMP-3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia.
Authors: Crocker SJ, Frausto RF, Whitton JL, Milner R
Glia, 2008-08-15;56(0):1187-98.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling.
Authors: Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG
Am. J. Pathol., 2008-06-05;173(1):57-67.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation.
Authors: Gurney KJ, Estrada EY, Rosenberg GA
Neurobiol. Dis., 2006-04-19;23(1):87-96.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
Authors: Behera AK, Hildebrand E, Scagliotti J, Steere AC, Hu LT
Infect. Immun., 2005-01-01;73(1):126-34.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P
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Antibody detects the active form of MMP-3 (45 kD)
