Netilmicin sulfate

Catalog #: 6339 Datasheet / COA / SDS

Discontinued Product

6339 has been discontinued.
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Netilmicin sulfate | CAS No. 56391-57-2 | Antiviral Compounds
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Description: Inhibits HIV-1 viral replication by blocking TAR-tat interaction

Chemical Name: O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N1-ethyl-D-streptamine sestersulfate

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Biological Activity

Binds the transactivation response element (TAR) of HIV-1 (Kd = 1.35 μM) and inhibits its interaction with Tat. Exhibits >35-fold selectivity for HIV-1 TAR over HIV-2 TAR or A-site and RRE RNA. Inhibits Tat-mediated HIV-1 activation and replication in T-cells in vitro. Also semisynthetic aminoglycoside antibiotic.

Technical Data

M.Wt:
720.78
Formula:
C21H41N5O7.2.5H2SO4
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
56391-57-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble.
    Stelzer et al.
    Nat.Chem.Biol., 2011;7:553
  2. The emerging role of RNA as a therapeutic target for small molecules.
    Connelly et al.
    Cell.Chem.Biol., 2016;23:1077

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⚠ WARNING: This product can expose you to chemicals including Netilmicin sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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