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Omipalisib

Catalog #: 6792 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6792/10
6792/50
Omipalisib | CAS No. 1086062-66-9 | PI 3-Kinase Inhibitors
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Description: Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
Alternative Names: GSK2126458

Chemical Name: 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide

Purity: ≥98%

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Biological Activity

Omipalisib is a highly potent PI 3-K inhibitor (IC50 = 0.04 nM). Also inhibits mTOR (Ki = 0.18 - 0.3 nM) and DNA-PK (IC50 = 0.28 nM). Induces G1 cell cycle arrest and inhibits proliferation of some breast cancer cells lines in vitro. Reduces pAKT-S473 levels in and inhibits growth of BT474 breast cancer xenografts in mice. Orally bioavailable.

Technical Data

M.Wt:
505.5
Formula:
C25H17F2N5O3S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1086062-66-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin.
    Knight et al.
    ACS Med.Chem.Lett., 2010;1:39

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