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PAR Monoclonal Antibody Affinity Purified

Catalog #: 4335-AMC-050
5 Citations Datasheet / COA / SDS
Newer Version Available: 4335-MC-100
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Discontinued Product

4335-AMC-050 has been discontinued and is replaced by 4335-MC-100.

Product Details
Citations (5)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

PAR Monoclonal Antibody Affinity Purified Summary

Source
Monoclonal Clone # 10HA
Label
Unconjugated
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: PAR/pADPr

PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.

Long Name
Poly [ADP-ribose] Polymer
Alternate Names
pADPr; PAR; Poly(ADP-ribose)

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Citations for PAR Monoclonal Antibody Affinity Purified

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Nuclear translocation of Gasdermin D sensitizes colorectal cancer to chemotherapy in a pyroptosis-independent manner
    Authors: X Peng, R Na, W Zhou, X Meng, Y Yang, S Amini, L Song
    Oncogene, 2022-10-16;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. Restoration of energy homeostasis by SIRT6 extends healthy lifespan
    Authors: A Roichman, S Elhanati, MA Aon, I Abramovich, A Di Frances, Y Shahar, MY Avivi, M Shurgi, A Rubinstein, Y Wiesner, A Shuchami, Z Petrover, I Lebenthal-, O Yaron, A Lyashkov, C Ubaida-Moh, Y Kanfi, B Lerrer, PJ Fernández-, M Serrano, E Gottlieb, R de Cabo, HY Cohen
    Nature Communications, 2021-05-28;12(1):3208.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  3. Sp1-independent downregulation of NHEJ in response to BER deficiency
    Authors: PS Loshchenov, SV Sergeeva, DV Limonov, Z Guo, GL Dianov
    DNA Repair (Amst.), 2019-11-11;86(0):102740.
    Species: Human
    Sample Types: Whole Cells
    Applications: Western Blot
  4. Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
    Authors: S Kim, S Han, Y Kim, HS Kim, YR Gu, D Kang, Y Cho, H Kim, J Lee, Y Seo, MJ Chang, CB Chang, SB Kang, JH Kim
    Nat Commun, 2019-10-25;10(1):4898.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. PARP1 Suppresses the Transcription of PD-L1 by Poly(ADP-Ribosyl)ating STAT3
    Authors: L Ding, X Chen, X Xu, Y Qian, G Liang, F Yao, Z Yao, H Wu, J Zhang, Q He, B Yang
    Cancer Immunol Res, 2018-11-06;0(0):.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-P, Immunoprecipitation, Western Blot

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