PI 3065
Chemical Name: 6-[[4-(Cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
Purity: ≥98%
Biological Activity
PI 3065 is a potent and selective PI 3-kinase p110δ inhibitor (IC50 = 5 nM; Ki = 1.5 nM). Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Targeting PI3K/Akt/mTOR signaling in cancer.
Porta et al.
Front.Oncol., 2014;4:64 -
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
Ali et al.
Nature, 2014;510:407
Product Datasheets
Citation for PI 3065
The citations listed below are publications that use Tocris products. Selected citations for PI 3065 include:
1 Citation: Showing 1 - 1
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Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
Authors: Cornelis F Et al.
Immunity 2017;47:1067-1082.e12
FAQs
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