PPTN hydrochloride

Catalog #: 4862
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4862/10

PPTN hydrochloride | CAS No. 1992047-65-0 | P2Y Receptor Antagonists

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Description: High affinity and selective P2Y14 antagonist

Chemical Name: 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride

Purity: ≥98%

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Product Details

Citations (2)

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Biological Activity

PPTN hydrochloride is a high affinity and selective P2Y₁₄ antagonist (K_B = 434 pM), which exhibits >10,000-fold selectivity for P2Y₁₄ over other P2Y receptors. PPTN inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo, and also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PPTN is reviewed.

Technical Data

M.Wt:

511.96

Formula:

C₂₉H₂₄F₃NO₂.HCl

Solubility:

Soluble to 100 mM in DMSO and to 20 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1992047-65-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Novel vasocontractile role of the P2Y₁₄ receptor: characterization of its signalling in porcine isolated pancreatic arteries.
Alsaqati et al.
Br.J.Pharmacol., 2014;171:701
A selective high-affinity antagonist of the P2Y₁₄ receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.
Barrett et al.
Mol.Pharmacol., 2013;84:41
The role of P2Y₁₄ and other P2Y receptors in degranulation of human LAD2 mast cells.
Gao et al.
Purinergic Signal., 2013;9:31

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Citations for PPTN hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PPTN hydrochloride include:

2 Citations: Showing 1 - 2

P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis.
Authors: Tilat A Et al.
Elife 2022;11
Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.
Authors: Dennis Et al.
J Clin Invest 2020;130:3734-3749

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