Quantikine Immunoassay Control Set 822 Human Total PAI-1

Quantikine Immunoassay Control Set 822 Human Total PAI-1 Summary

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Product Datasheets

Background: Serpin E1/PAI-1

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Related Research Areas

• Adipocytokines
• Alpha Granule Soluble Molecules
• Cancer Biomarkers
• Coagulation
• Complement Pathway
• DNA Damage and Repair
• Enzymes Secreted by Endothelial Cells
• Mesenchymal Cells and EMT
• Plasmin/Plasminogen and Kallikrein/Kinin Systems
• Search Cytokine and Growth Factor Products
• Serine Proteases and Regulators