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RBC8

Catalog #: 5411 Datasheet / COA / SDS

Discontinued Product

5411 has been discontinued.
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RBC8 | CAS No. 361185-42-4 | Ras GTPase Inhibitors
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Description: RalA and RalB inhibitor

Chemical Name: 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile

Purity: ≥98%

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Biological Activity

RBC8 is a RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). Inhibits the binding of Ral to RaLBP1. Exhibits no detectable inhibition of Ras or RhoA activity. Suppresses growth of xenograft tumors in mice. Cell permeable.

Technical Data

M.Wt:
424.45
Formula:
C25H20N4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
361185-42-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery and characterization of small molecules that target the GTPase Ral.
    Yan et al.
    Nature, 2014;515:443

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