Can Recombinant Human BMP-4 Protein (Catalog # 314-BP or 314-BP/CF) be reconstituted in PBS or water?

Name: Recombinant Human BMP-4 Protein
Brand: R&D Systems
SKU: 314-BP
Rating: 4.9 (13 reviews)

Recombinant Human BMP-4 (Catalog # 314-BP or 314-BP/CF) needs to be reconstituted to 50-200 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl to ensure optimal recovery, stability, and activity. This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

Recombinant Human BMP-4 Protein

Catalog #: 314-BP
519 Citations 13 Reviews Datasheet / COA / SDS

Carrier Free

Catalog #	Availability	Size / Price	Qty
314-BP-010/CF
314-BP-050/CF
314-BP-500/CF
314-BP-020/CF

With Carrier

Catalog #	Availability	Size / Price	Qty
314-BP-010
314-BP-050
314-BP-01M
314-BP-500
314-BP-020

Recombinant Human BMP-4 Protein Bioactivity

2 Images

All BMP-4 Proteins and Enzymes

Product Details

Citations (519)

FAQs

Reviews (13)

Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human BMP-4 Protein Summary

Product Specifications

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.01 EU per 1 μg of the protein by the LAL method.

Activity

Measured by its ability to induce BMP responsive SEAP reporter activity in HEK293 human embryonic kidney cells. The ED₅₀ for this effect is 0.70-7.00 ng/mL. Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem. Biophys. Res. Commun. 315(2):272. The ED₅₀ for this effect is 3.00-30.0 ng/mL.

Source

Mouse myeloma cell line, NS0-derived human BMP-4 protein
Ser293-Arg408

Accession #

Q53XC5

N-terminal Sequence
Analysis

Ser293

Structure / Form

Disulfide-linked homodimer

Predicted Molecular Mass

13 kDa (monomer)

SDS-PAGE

19-24 kDa, reducing conditions
35-41 kDa, non-reducing conditions

Product Datasheets

314-BP (with carrier)

Product Datasheet

COA

SDS

314-BP/CF (carrier free)

Product Datasheet

COA

SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

314-BP

Formulation	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Reconstitution	Reconstitute at 50-200 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -70 °C under sterile conditions after reconstitution.

314-BP/CF

Formulation	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution	Reconstitute at 50-200 μg/mL in sterile 4 mM HCl.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity

View Larger

Recombinant Human BMP‑4 (Catalog # 314-BP) induces BMP responsive SEAP reporter activity in HEK293 human embryonic kidney cells. The ED₅₀ for this effect is 0.70-7.00 ng/mL.

SDS-PAGE

View Larger

1 μg/lane of Recombinant Human BMP-4 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing major bands at 19-24 kDa and 35-41 kDa, respectively. Multiple bands in gel are due to variable glycosylation.

Reconstitution Calculator

Background: BMP-4

BMP-4 is a TGF-beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. It plays an important role in mesenchyme formation, epidermal determination, suppression of neural induction, the development of multiple organs, and tissue repair (1-5). The human BMP-4 precursor contains a 273 amino acid (aa) propeptide and a 116 aa mature protein (6). Processing of the propeptide by furin or proprotein convertase 6 enables the formation of the mature disulfide-linked homodimeric BMP-4 and facilitates its secretion. Similar intracellular processes may lead to the formation and recreation of BMP4/BMP7
disulfide-linked heterodimer (7-9). Mature human and mouse BMP-4 share 98% aa sequence identity. Human BMP-4 shares 85% aa sequence identity with human BMP-2 and less than 50% with other human BMPs. Compared to BMP-4 homodimers, BMP-4/BMP-7 heterodimers exhibit a greater potency in inducing osteogenic differentiation (9). In Xenopus, the heterodimers can also induce the formation of mesoderm, whereas BMP-4 homodimers only provide ventralizing signals for existing mesoderm (10). BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (11, 12). The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans (13-15).

References

Zhang, P. et al. (2008) Blood 111:1933.
Gambaro, K. et al. (2006) Cell Death Differ. 13:1075.
Simic, P. and S. Vukicevic (2005) Cytokine Growth Factor Rev. 16:299.
Sadlon, T.J. et al. (2004) Stem Cells 22:457.
Frank, D.B. et al. (2005) Circ. Res. 97:496.
Wozney, J. et al. (1988) Science 242:1528.
Cui, Y. et al. (1998) EMBO J. 17:4735.
Cui, Y. et al. (2001) Genes Dev. 15:2797.
Aono, A. et al. (1995) Biochem. Biophys. Res. Commun. 210:670.
Nishimatsu, S. and G.H. Thomsen (1998) Mech. Dev. 74:75.
Chen, D. et al. (2004) Growth Factors 22:233.
Lavery, K. et al. (2008) J. Biol. Chem. April 24 epub.
Rosen, V. (2006) Ann. N.Y. Acad. Sci. 1068:19.
Jones, C.M. and J.C. Smith (1998) Dev. Biol. 194:12.
Takada, T. et al. (2003) J. Biol. Chem. 278:43229.

Long Name

Bone Morphogenetic Protein 4

Entrez Gene IDs

652 (Human); 12159 (Mouse); 25296 (Rat); 30612 (Zebrafish)

Alternate Names

BMP2B; BMP-2B; BMP2B1; BMP2BMCOPS6; BMP4; BMP-4; Bone morphogenetic protein 2B; bone morphogenetic protein 4; DVR4; MCOPS6; OFC11; ZYME

Related Research Areas

Citations for Recombinant Human BMP-4 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

519 Citations: Showing 1 - 10
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Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging
Authors: Kurosawa, T;Ikemoto-Uezumi, M;Yoshimoto, Y;Minato, K;Kaji, N;Chaen, T;Hase, E;Minamikawa, T;Yasui, T;Horiguchi, K;Iino, S;Hori, M;Uezumi, A;
Aging cell
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids
Authors: Li, J;Wiesinger, A;Fokkert, L;Bakker, P;de Vries, DK;Tijsen, AJ;Pinto, YM;Verkerk, AO;Christoffels, VM;Boink, GJJ;Devalla, HD;
Cell stem cell
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture
Authors: Lekkala, VKR;Shrestha, S;Al Qaryoute, A;Dhinoja, S;Acharya, P;Raheem, A;Jagadeeswaran, P;Lee, MY;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/?-catenin activation
Authors: Liang, Z;Huang, T;Li, W;Ma, Z;Wang, K;Zhai, Z;Fan, Y;Fu, Y;Wang, X;Qin, Y;Wang, B;Zhao, C;Kuang, J;Pei, D;
Nucleic acids research
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells
Authors: Kent, GM;Atkins, MH;Lung, B;Nikitina, A;Fernandes, IM;Kwan, JJ;Andrews, TS;MacParland, SA;Keller, GM;Gage, BK;
Cell reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
Rapid and efficient generation of mature retinal organoids derived from human pluripotent stem cells via optimized pharmacological modulation of Sonic hedgehog, activin A, and retinoic acid signal transduction
Authors: Matsushita, T;Onishi, A;Matsuyama, T;Masuda, T;Ogino, Y;Kageyama, M;Takahashi, M;Uchiumi, F;
PloS one
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development
Authors: Zhang, R;Wu, M;Xiang, D;Zhu, J;Zhang, Q;Zhong, H;Peng, Y;Wang, Z;Ma, G;Li, G;Liu, F;Ye, W;Shi, R;Zhou, X;Babarinde, IA;Su, H;Chen, J;Zhang, X;Qin, D;Hutchins, AP;Pei, D;Li, D;
Cell stem cell
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
Single-cell RNA sequencing reveals placental response under environmental stress
Authors: Van Buren, E;Azzara, D;Rangel-Moreno, J;Garcia-Hernandez, ML;Murphy, SP;Cohen, ED;Lewis, E;Lin, X;Park, HR;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity
Authors: Quach, H;Farrell, S;Wu, MJM;Kanagarajah, K;Leung, JW;Xu, X;Kallurkar, P;Turinsky, AL;Bear, CE;Ratjen, F;Kalish, B;Goyal, S;Moraes, TJ;Wong, AP;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis
Authors: Bisson, JA;Gordillo, M;Kumar, R;de Silva, N;Yang, E;Banks, KM;Shi, ZD;Lee, K;Yang, D;Chung, WK;Huangfu, D;Evans, T;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids
Authors: Jo, K;Liu, ZY;Patel, G;Yu, Z;Yao, L;Teague, S;Johnson, C;Spence, J;Heemskerk, I;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms
Authors: Landau, S;Zhao, Y;Hamidzada, H;Kent, GM;Okhovatian, S;Lu, RXZ;Liu, C;Wagner, KT;Cheung, K;Shawky, SA;Vosoughi, D;Beroncal, EL;Fernandes, I;Cummins, CL;Andreazza, AC;Keller, GM;Epelman, S;Radisic, M;
Cell stem cell
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction
Authors: ??, Ö;Wang, X;Reddy, JS;Min, Y;Yilmaz, E;Bhattarai, P;Patel, T;Bergman, J;Quicksall, Z;Heckman, MG;Tutor-New, FQ;Can Demirdogen, B;White, L;Koga, S;Krause, V;Inoue, Y;Kanekiyo, T;Cosacak, MI;Nelson, N;Lee, AJ;Vardarajan, B;Mayeux, R;Kouri, N;Deniz, K;Carnwath, T;Oatman, SR;Lewis-Tuffin, LJ;Nguyen, T;Alzheimers Disease Neuroimaging Initiative, ;Carrasquillo, MM;Graff-Radford, J;Petersen, RC;Jr Jack, CR;Kantarci, K;Murray, ME;Nho, K;Saykin, AJ;Dickson, DW;Kizil, C;Allen, M;Ertekin-Taner, N;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of human cerebral organoids with a structured outer subventricular zone
Authors: Walsh, RM;Luongo, R;Giacomelli, E;Ciceri, G;Rittenhouse, C;Verrillo, A;Galimberti, M;Bocchi, VD;Wu, Y;Xu, N;Mosole, S;Muller, J;Vezzoli, E;Jungverdorben, J;Zhou, T;Barker, RA;Cattaneo, E;Studer, L;Baggiolini, A;
Cell reports
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

Integration of Kupffer cells into human iPSC-derived liver organoids for modeling liver dysfunction in sepsis
Authors: Li, Y;Nie, Y;Yang, X;Liu, Y;Deng, X;Hayashi, Y;Plummer, R;Li, Q;Luo, N;Kasai, T;Okumura, T;Kamishibahara, Y;Komoto, T;Ohkuma, T;Okamoto, S;Isobe, Y;Yamaguchi, K;Furukawa, Y;Taniguchi, H;
Cell reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Smad4 is essential for epiblast scaling and morphogenesis after implantation, but nonessential prior to implantation in the mouse
Authors: Kruger, RE;Frum, T;Brumm, AS;Hickey, SL;Niakan, KK;Aziz, F;Shammami, MA;Roberts, JG;Ralston, A;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Embryo
Applications: Bioassay

Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes
Authors: Johnson, BB;Cosson, MV;Tsansizi, LI;Holmes, TL;Gilmore, T;Hampton, K;Song, OR;Vo, NTN;Nasir, A;Chabronova, A;Denning, C;Peffers, MJ;Merry, CLR;Whitelock, J;Troeberg, L;Rushworth, SA;Bernardo, AS;Smith, JGW;
Cell reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Selective gene expression maintains human tRNA anticodon pools during differentiation
Authors: Gao, L;Behrens, A;Rodschinka, G;Forcelloni, S;Wani, S;Strasser, K;Nedialkova, DD;
Nature cell biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cell development
Authors: Hwang, YS;Seita, Y;Blanco, MA;Sasaki, K;
PLoS genetics
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Assessment of Fallopian Tube Epithelium Features Derived from Induced Pluripotent Stem Cells of Both Fallopian Tube and Skin Origins
Authors: Chang, YH;Wu, KC;Wang, KH;Ding, DC;
Cells
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A degron-based approach to manipulate Eomes functions in the context of the developing mouse embryo
Authors: Bisia, AM;Costello, I;Xypolita, ME;Harland, LTG;Kurbel, PJ;Bikoff, EK;Robertson, EJ;
Proceedings of the National Academy of Sciences of the United States of America
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD22 is a potential target of CAR-NK cell therapy for esophageal squamous cell carcinoma
Authors: Liu, T;Dai, X;Xu, Y;Guan, T;Hong, L;Zaib, T;Zhou, Q;Cheng, K;Zhou, X;Ma, C;Sun, P;
Journal of translational medicine
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of ligand-receptor pairs that drive human astrocyte development
Authors: Voss, AJ;Lanjewar, SN;Sampson, MM;King, A;Hill, EJ;Sing, A;Sojka, C;Bhatia, TN;Spangle, JM;Sloan, SA;
Nature neuroscience
Species: Human
Sample Types: Organoid
Applications: Bioassay

Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids
Authors: Ai, Z;Niu, B;Yin, Y;Xiang, L;Shi, G;Duan, K;Wang, S;Hu, Y;Zhang, C;Zhang, C;Rong, L;Kong, R;Chen, T;Guo, Y;Liu, W;Li, N;Zhao, S;Zhu, X;Mai, X;Li, Y;Wu, Z;Zheng, Y;Fu, J;Ji, W;Li, T;
Cell research
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP
Authors: Zhang, H;Kafeiti, N;Lee, S;Masarik, K;Zheng, H;Zhan, H;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme
Authors: Alber, AB;Marquez, HA;Ma, L;Kwong, G;Thapa, BR;Villacorta-Martin, C;Lindstrom-Vautrin, J;Bawa, P;Wang, F;Luo, Y;Ikonomou, L;Shi, W;Kotton, DN;
Nature communications
Species: Transgenic Mouse
Sample Types: Organoid
Applications: Bioassay

Single-cell sequencing of individual retinal organoids reveals determinants of cell fate heterogeneity
Authors: Tresenrider, A;Sridhar, A;Eldred, KC;Cuschieri, S;Hoffer, D;Trapnell, C;Reh, TA;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Embryoid Bodies, Whole Cells
Applications: Bioassay

Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21
Authors: Maeda, Y;Isomura, A;Masaki, T;Kageyama, R;
Cell reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
Authors: Matkovic Leko, I;Schneider, RT;Thimraj, TA;Schrode, N;Beitler, D;Liu, HY;Beaumont, K;Chen, YW;Snoeck, HW;
Nature protocols
Species: Human
Sample Types: Whole Cells, Embryoid Bodies, Organoid
Applications: Bioassay

Opposing roles for TGF?- and BMP-signaling during nascent alveolar differentiation in the developing human lung
Authors: Frum, T;Hsu, PP;Hein, RFC;Conchola, AS;Zhang, CJ;Utter, OR;Anand, A;Zhang, Y;Clark, SG;Glass, I;Sexton, JZ;Spence, JR;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
Authors: Majd, H;Amin, S;Ghazizadeh, Z;Cesiulis, A;Arroyo, E;Lankford, K;Majd, A;Farahvashi, S;Chemel, AK;Okoye, M;Scantlen, MD;Tchieu, J;Calder, EL;Le Rouzic, V;Shibata, B;Arab, A;Goodarzi, H;Pasternak, G;Kocsis, JD;Chen, S;Studer, L;Fattahi, F;
Cell stem cell
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting neuronal lysosomal dysfunction caused by beta-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct
Authors: A Gehrlein, V Udayar, N Anastasi, ML Morella, I Ruf, D Brugger, S von der Ma, R Thoma, A Rufer, D Heer, N Pfahler, A Jochner, J Niewoehner, L Wolf, M Fueth, M Ebeling, R Villaseñor, Y Zhu, MC Deen, X Shan, Z Ehsaei, V Taylor, E Sidransky, DJ Vocadlo, PO Freskgård, R Jagasia
Nature Communications, 2023-04-12;14(1):2057.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The time integral of BMP signaling determines fate in a stem cell model for early human development
Authors: S Teague, G Primavera, B Chen, E Freeburne, H Khan, K Jo, C Johnson, I Heemskerk
bioRxiv : the preprint server for biology, 2023-04-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Strength of CAR signaling determines Tï¿½cell versus ILC differentiation from pluripotent stem cells
Authors: S Li, CS Wang, A Montel-Hag, HC Chen, S Lopez, O Zhou, K Dai, S Tsai, W Satyadi, C Botero, C Wong, D Casero, GM Crooks, CS Seet
Cell Reports, 2023-03-11;42(3):112241.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease
Authors: Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer
Cell Stem Cell, 2023-03-02;30(3):264-282.e9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling
Authors: M Shono, K Kishimoto, O Hikabe, M Hayashi, K Semi, Y Takashima, E Sasaki, K Kato, K Hayashi
Scientific Reports, 2023-02-23;13(1):3186.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
Authors: AR Dicks, GI Maksaev, Z Harissa, A Savadipour, R Tang, N Steward, W Liedtke, CG Nichols, CL Wu, F Guilak
Elife, 2023-02-22;12(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pervasive environmental chemicals impair oligodendrocyte development
Authors: EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar
bioRxiv : the preprint server for biology, 2023-02-12;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8
Authors: N Wang, J He, X Feng, S Liao, Y Zhao, F Tang, K Kee
Elife, 2023-01-05;12(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease
Authors: Y Fan, J Hackland, A Baggiolini, LY Hung, H Zhao, P Zumbo, P Oberst, AP Minotti, E Hergenrede, S Najjar, Z Huang, NM Cruz, A Zhong, M Sidharta, T Zhou, E de Stanchi, D Betel, RM White, M Gershon, KG Margolis, L Studer
Cell Stem Cell, 2023;30(3):264-282.e9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses
Authors: L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy
Viruses, 2022-12-29;15(1):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In vitro elastic cartilage reconstruction using human auricular perichondrial chondroprogenitor cell-derived micro 3D spheroids
Authors: T Oba, S Okamoto, Y Ueno, M Matsuo, T Tadokoro, S Kobayashi, K Yasumura, S Kagimoto, Y Inaba, H Taniguchi
Journal of tissue engineering, 2022-12-23;13(0):2041731422114.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods
Authors: Q Liu, Z Liu, H Gu, Y Ge, X Wu, F Zuo, Q Du, Y Lei, Z Wang, H Lin
Regenerative Therapy, 2022-12-21;22(0):39-49.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Robust induction of primordial germ cells of white rhinoceros on the brink of extinction
Authors: M Hayashi, V Zywitza, Y Naitou, N Hamazaki, F Goeritz, R Hermes, S Holtze, G Lazzari, C Galli, J Stejskal, S Diecke, TB Hildebrand, K Hayashi
Science Advances, 2022-12-09;8(49):eabp9683.
Species: Rhinoceros
Sample Types: Cell Culture Supernates
Applications: Bioassay

Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
Authors: JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson
Cell Reports, 2022-12-06;41(10):111775.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

INO80 Is Required for the Cell Cycle Control, Survival, and Differentiation of Mouse ESCs by Transcriptional Regulation
Authors: S Yoo, EJ Lee, NX Thang, H La, H Lee, C Park, DW Han, SJ Uhm, H Song, JT Do, Y Choi, K Hong
International Journal of Molecular Sciences, 2022-12-06;23(23):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
Authors: JP Borges, RSR Sætra, A Volchuk, M Bugge, P Devant, B Sporsheim, BR Kilburn, CL Evavold, JC Kagan, NM Goldenberg, TH Flo, BE Steinberg
Elife, 2022-12-05;11(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders
Authors: D Shang, T Lan, Y Wang, X Li, Q Liu, H Dong, B Xu, H Cheng, R Zhou
Cell & bioscience, 2022-12-01;12(1):194.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate
Authors: Z Li, F Fang, Y Long, Q Zhao, X Wang, Z Ye, T Meng, X Gu, W Xiang, C Xiong, H Li
Cell & bioscience, 2022-11-04;12(1):181.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
Authors: K Leng, IVL Rose, H Kim, W Xia, W Romero-Fer, B Rooney, M Koontz, E Li, Y Ao, S Wang, M Krawczyk, J Tcw, A Goate, Y Zhang, EM Ullian, MV Sofroniew, SPJ Fancy, MS Schrag, ES Lippmann, M Kampmann
Nature Neuroscience, 2022-10-27;25(11):1528-1542.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery
Authors: YS Yang, JM Kim, J Xie, S Chaugule, C Lin, H Ma, E Hsiao, J Hong, H Chun, EM Shore, FS Kaplan, G Gao, JH Shim
Oncogene, 2022-10-19;13(1):6175.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models
Authors: J Li, A Wiesinger, L Fokkert, BJ Boukens, AO Verkerk, VM Christoffe, GJJ Boink, HD Devalla
Journal of tissue engineering, 2022-10-18;13(0):2041731422112.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Improved Sendai viral system for reprogramming to naive pluripotency.
Authors: Kunitomi A, Hirohata R, Arreola V, Osawa M, Kato T, Nomura M, Kawaguchi J, Hara H, Kusano K, Takashima Y, Takahashi K, Fukuda K, Takasu N, Yamanaka S
Cell Rep Methods, 2022-10-17;2(11):100317.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A
Authors: A Beucher, I Miguel-Esc, D Balboa, MG De Vas, MA Maestro, J Garcia-Hur, A Bernal, R Gonzalez-F, P Vargiu, H Heyn, P Ravassard, S Ortega, J Ferrer
Nature Cell Biology, 2022-10-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Successful Derivation of Hepatoblasts, Cholangiocytes and Hepatocytes from Simian Induced Pluripotent Stem Cells
Authors: E Luce, C Steichen, S Abed, A Weber, P Leboulch, L Maouche-Ch, A Dubart-Kup
International Journal of Molecular Sciences, 2022-09-17;23(18):.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Bioassay

Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner
Authors: J Liu, Z Liu, J Zhang, X Chen, J Chen, L Sui, J Yu
Pharmaceutics, 2022-09-05;14(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modeling human multi-lineage heart field development with pluripotent stem cells
Authors: D Yang, J Gomez-Garc, S Funakoshi, T Tran, I Fernandes, GD Bader, MA Laflamme, GM Keller
Cell Stem Cell, 2022-09-01;29(9):1382-1401.e8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
Authors: Y Tang, DJ Kwiatkowsk, EP Henske
Nature Communications, 2022-08-26;13(1):5018.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay
Authors: S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller
Nature Communications, 2022-08-25;13(1):5003.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Krï¿½ppel-like factor 5 rewires NANOG regulatory network to activate human naive pluripotency specific LTR7Ys and promote naive pluripotency
Authors: Z Ai, X Xiang, Y Xiang, I Szczerbins, Y Qian, X Xu, C Ma, Y Su, B Gao, H Shen, MN Bin Ramli, D Chen, Y Liu, JJ Hao, HH Ng, D Zhang, YS Chan, W Liu, H Liang
Cell Reports, 2022-08-23;40(8):111240.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems
Authors: K Kishimoto, K Iwasawa, A Sorel, C Ferran-Her, L Han, M Morimoto, JM Wells, T Takebe, AM Zorn
Nature Protocols, 2022-08-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

EZH1 repression generates mature iPSC-derived CAR Tï¿½cells with enhanced antitumor activity
Authors: R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley
Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells
Authors: X Fan, L Cyganek, K Nitschke, S Uhlig, P Nuhn, K Bieback, D Duerschmie, I El-Battraw, X Zhou, I Akin
International Journal of Molecular Sciences, 2022-07-31;23(15):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer
Authors: Z Shonibare, M Monavarian, K O'Connell, D Altomare, A Shelton, S Mehta, R Jaskula-Sz, R Phaeton, MD Starr, R Whitaker, A Berchuck, AB Nixon, RC Arend, NY Lee, CR Miller, N Hempel, K Mythreye
Oncogene, 2022-07-26;40(4):111066.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sox2 in the dermal papilla regulates hair follicle pigmentation
Authors: KJ Ng, J Lim, YN Tan, D Quek, Z Lim, N Pantelirei, C Clavel
Oncogene, 2022-07-19;40(3):111100.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism
Authors: YK Cho, YC Yoon, H Im, Y Son, M Kim, A Saha, C Choi, J Lee, S Lee, JH Kim, YP Kang, YS Jung, HK Ha, JK Seong, JG Granneman, SW Kwon, YH Lee
Nature Communications, 2022-07-14;13(1):4084.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells
Authors: D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz
Elife, 2022-07-11;11(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model
Authors: M Ohgushi, N Taniyama, A Vandenbon, M Eiraku
Cell Reports, 2022-06-21;39(12):110973.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting
Authors: Y Tsujisaka, T Hatani, C Okubo, R Ito, A Kimura, M Narita, K Chonabayas, S Funakoshi, A Lucena-Cac, T Toyoda, K Osafune, T Kimura, H Saito, Y Yoshida
Stem Cell Reports, 2022-06-09;0(0):.
Species: Human
Sample Types: Embryoid Bodies
Applications: Bioassay

MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis
Authors: Y Hayashi, KC Kawabata, Y Tanaka, Y Uehara, Y Mabuchi, K Murakami, A Nishiyama, S Kiryu, Y Yoshioka, Y Ota, T Sugiyama, K Mikami, M Tamura, T Fukushima, S Asada, R Takeda, Y Kunisaki, T Fukuyama, K Yokoyama, T Uchida, M Hagihara, N Ohno, K Usuki, A Tojo, Y Katayama, S Goyama, F Arai, T Tamura, T Nagasawa, T Ochiya, D Inoue, T Kitamura
Cell Reports, 2022-05-10;39(6):110805.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application
Authors: JM Rivera-Arb, C Cofiño-Fab, V Schwach, T Boonen, SA Ten Den, K Vermeul, A van den Be, LI Segerink, MC Ribeiro, R Passier
PLoS ONE, 2022-04-14;17(4):e0266834.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors
Authors: BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller
Cell Reports, 2022-04-05;39(1):110621.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development
Authors: J Krumm, K Sekine, P Samaras, A Brazovskaj, M Breunig, R Yasui, A Kleger, H Taniguchi, M Wilhelm, B Treutlein, JG Camp, B Kuster
Cell Reports, 2022-03-29;38(13):110604.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids
Authors: J Jeong, TH Kim, M Kim, YK Jung, KS Kim, S Shim, H Jang, WI Jang, SB Lee, D Choi
Biology, 2022-03-23;11(4):.
Species: Human
Sample Types: Transduced Whole Cells
Applications: Bioassay

3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR Tï¿½cells
Authors: Z Wang, HP McWilliams, H Reza, JR Ostberg, W Chen, X Wang, C Huynh, V Vyas, WC Chang, R Starr, JR Wagner, B Aguilar, X Yang, X Wu, J Wang, W Chen, E Koelker-Wo, CS Seet, A Montel-Hag, GM Crooks, SJ Forman, CE Brown
Cell Stem Cell, 2022-03-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Naï¿½ve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction
Authors: V Zywitza, E Rusha, D Shaposhnik, J Ruiz-Orera, N Telugu, V Rishko, M Hayashi, G Michel, L Wittler, J Stejskal, S Holtze, F Göritz, R Hermes, J Wang, Z Izsvák, S Colleoni, G Lazzari, C Galli, TB Hildebrand, K Hayashi, S Diecke, M Drukker
Scientific Reports, 2022-03-08;12(1):3100.
Species: Northern White Rhinoceros
Sample Types: Whole Cells
Applications: Bioassay

Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids
Authors: K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi
Stem Cell Reports, 2022-03-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea
Authors: XJ Li, C Morgan, LA Goff, A Doetzlhofe
Science Advances, 2022-02-11;8(6):eabj7651.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay

Operation of the Atypical Canonical Bone Morphogenetic Protein Signaling Pathway During Early Human Odontogenesis
Authors: X Hu, C Lin, N Ruan, Z Huang, Y Zhang, X Hu
Frontiers in Physiology, 2022-02-08;13(0):823275.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues
Authors: MC Ribeiro, JM Rivera-Arb, C Cofiño-Fab, V Schwach, RH Slaats, SA Ten Den, K Vermeul, A van den Be, JM Pérez-Poma, LI Segerink, JA Guadix, R Passier
Journal of personalized medicine, 2022-02-04;12(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Paraxial mesoderm organoids model development of human somites
Authors: C Budjan, S Liu, A Ranga, S Gayen, O Pourquié, S Hormoz
Elife, 2022-01-28;11(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition
Authors: C Finkbeiner, I Ortuño-Liz, A Sridhar, M Hooper, S Petter, TA Reh
Cell Reports, 2022-01-25;38(4):110294.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections
Authors: X Xiang, Y Tao, J DiRusso, FM Hsu, J Zhang, Z Xue, J Pontis, D Trono, W Liu, AT Clark
Nature Communications, 2022-01-24;13(1):463.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
Authors: JJ Kathiriya, C Wang, M Zhou, A Brumwell, M Cassandras, CJ Le Saux, M Cohen, KD Alysandrat, B Wang, P Wolters, M Matthay, DN Kotton, HA Chapman, T Peng
Nature Cell Biology, 2021-12-30;0(0):.
Species: Human
Sample Types: Organoid
Applications: Bioassay

Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis
Authors: N Yucer, R Ahdoot, MJ Workman, AH Laperle, MS Recouvreux, K Kurowski, DJ Naboulsi, V Liang, Y Qu, JT Plummer, SA Gayther, S Orsulic, BY Karlan, CN Svendsen
Cell Reports, 2021-12-28;37(13):110146.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells
Authors: AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells
Cell Stem Cell, 2021-12-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells
Authors: F Xu, C Deng, Z Ren, L Sun, Y Meng, W Liu, J Wan, G Chen
Cell Reports, 2021-11-30;37(9):110063.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
Authors: RJ Geusz, A Wang, DK Lam, NK Vinckier, KD Alysandrat, DA Roberts, J Wang, S Kefalopoul, A Ramirez, Y Qiu, J Chiou, KJ Gaulton, B Ren, DN Kotton, M Sander
Nature Communications, 2021-11-17;12(1):6636.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients
Authors: AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles
Cells, 2021-11-10;10(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modulating mesendoderm competence during human germ layer differentiation
Authors: JR Valcourt, RE Huang, S Kundu, D Venkatasub, RE Kingston, S Ramanathan
Cell Reports, 2021-11-09;37(6):109990.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An airway organoid-based screen identifies a role for the HIF1alpha-glycolysis axis in SARS-CoV-2 infection
Authors: X Duan, X Tang, MS Nair, T Zhang, Y Qiu, W Zhang, P Wang, Y Huang, J Xiang, H Wang, RE Schwartz, DD Ho, T Evans, S Chen
Cell Reports, 2021-10-15;37(6):109920.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development
Authors: M Zheng, S Erhardt, D Ai, J Wang
International Journal of Molecular Sciences, 2021-09-11;22(18):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Generation of human blastocyst-like structures from pluripotent stem cells
Authors: Y Fan, Z Min, S Alsolami, Z Ma, E Zhang, W Chen, K Zhong, W Pei, X Kang, P Zhang, Y Wang, Y Zhang, L Zhan, H Zhu, C An, R Li, J Qiao, T Tan, M Li, Y Yu
Cell Discovery, 2021-09-07;7(1):81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia
Authors: R Sun, L He, H Lee, A Glinka, C Andresen, D Hübschmann, I Jeremias, K Müller-Dec, C Pabst, C Niehrs
Cell Reports, 2021-08-17;36(7):109559.
Species: Human
Sample Types:
Applications: Bioassay

Improving In Vitro Culture of Human Male Fetal Germ Cells
Authors: M Martin-Ina, M Ferreira, J Taelman, C Eguizabal, SM Chuva De S
Cells, 2021-08-09;10(8):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes
Authors: K Sattler, I El-Battraw, L Cyganek, S Lang, H Lan, X Li, Z Zhao, J Utikal, T Wieland, M Borggrefe, X Zhou, I Akin
Scientific Reports, 2021-07-19;11(1):14689.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
Authors: M Sato, A Inohaya, E Yasuda, H Mogami, Y Chigusa, K Kawasaki, Y Kawamura, Y Ueda, H Takai, M Mandai, E Kondoh
Scientific Reports, 2021-07-08;11(1):14167.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells
Authors: MN Wosczyna, EE Perez Carb, MW Wagner, S Paredes, CT Konishi, L Liu, TT Wang, RA Walsh, Q Gan, CS Morrissey, TA Rando
Cell Stem Cell, 2021-05-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response
Authors: A Mithal, AJ Hume, J Lindstrom-, C Villacorta, J Olejnik, E Bullitt, A Hinds, E Mühlberger, G Mostoslavs
Stem Cell Reports, 2021-04-13;16(4):940-953.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Capturing human trophoblast development with naive pluripotent stem cells inï¿½vitro
Authors: S Io, M Kabata, Y Iemura, K Semi, N Morone, A Minagawa, B Wang, I Okamoto, T Nakamura, Y Kojima, C Iwatani, H Tsuchiya, B Kaswandy, E Kondoh, S Kaneko, K Woltjen, M Saitou, T Yamamoto, M Mandai, Y Takashima
Cell Stem Cell, 2021-04-07;28(6):1023-1039.e13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells
Authors: G Campostrin, V Meraviglia, E Giacomelli, RWJ van Helden, L Yiangou, RP Davis, M Bellin, VV Orlova, CL Mummery
Nature Protocols, 2021-03-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D
Authors: AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck
Nature Protocols, 2021-03-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate
Authors: TM Lu, S Houghton, T Magdeldin, JGB Durán, AP Minotti, A Snead, A Sproul, DT Nguyen, J Xiang, HA Fine, Z Rosenwaks, L Studer, S Rafii, D Agalliu, D Redmond, R Lis
Proceedings of the National Academy of Sciences of the United States of America, 2021-02-23;118(8):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Formative pluripotent stem cells show features of epiblast cells poised for gastrulation
Authors: X Wang, Y Xiang, Y Yu, R Wang, Y Zhang, Q Xu, H Sun, ZA Zhao, X Jiang, X Wang, X Lu, D Qin, Y Quan, J Zhang, N Shyh-Chang, H Wang, N Jing, W Xie, L Li
Cell Research, 2021-02-19;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets
Authors: T Wang, AR Pine, AG Kotini, H Yuan, L Zamparo, DT Starczynow, C Leslie, EP Papapetrou
Cell Stem Cell, 2021-02-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes
Authors: PP Shah, W Lv, JH Rhoades, A Poleshko, D Abbey, MA Caporizzo, R Linares-Sa, JG Heffler, N Sayed, D Thomas, Q Wang, LJ Stanton, K Bedi, MP Morley, TP Cappola, AT Owens, KB Margulies, DB Frank, JC Wu, DJ Rader, W Yang, BL Prosser, K Musunuru, R Jain
Cell Stem Cell, 2021-02-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Electrophysiological evaluation of human induced pluripotent stem cell-derived cardiomyocytes obtained by different methods
Authors: C Prajapati, M Ojala, H Lappi, K Aalto-Setä, M Pekkanen-M
Stem Cell Research, 2021-01-15;51(0):102176.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis
Authors: CL Wu, A Dicks, N Steward, R Tang, DB Katz, YR Choi, F Guilak
Nature Communications, 2021-01-13;12(1):362.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids
Authors: M Souidi, Y Sleiman, I Acimovic, J Pribyl, A Charrabi, V Baecker, V Scheuerman, M Pesl, S Jelinkova, P Skladal, P Dvorak, A Lacampagne, V Rotrekl, AC Meli
International Journal of Molecular Sciences, 2021-01-11;22(2):.
Species: Human
Sample Types: Organoid
Applications: Bioassay

Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells
Authors: H Fang, S Geng, M Hao, Q Chen, M Liu, C Liu, Z Tian, C Wang, T Takebe, JL Guan, Y Chen, Z Guo, W He, J Diao
Nature Communications, 2021-01-04;12(1):109.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The histone demethylase KDM2B regulates human primordial germ cell-like cells specification
Authors: W Yuan, Z Yao, V Veerapandi, X Yang, X Wang, D Chen, L Ma, C Li, Y Zheng, F Luo, XY Zhao
International journal of biological sciences, 2021-01-01;17(2):527-538.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Optimised generation of iPSC-derived macrophages and dendritic cells that are functionally and transcriptionally similar to their primary counterparts
Authors: S Monkley, JK Krishnaswa, M Göransson, M Clausen, J Meuller, K Thörn, R Hicks, S Delaney, L Stjernborg
PLoS ONE, 2020-12-17;15(12):e0243807.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling
Authors: K Uchimura, H Wu, Y Yoshimura, BD Humphreys
Cell Reports, 2020-12-15;33(11):108514.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A microfluidics-based stem cell model of early post-implantation human development
Authors: Y Zheng, Y Shao, J Fu
Nature Protocols, 2020-12-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Stem cell and niche regulation in human short bowel syndrome
Authors: VA Gazit, EA Swietlicki, MU Liang, A Surti, R McDaniel, M Geisman, DM Alvarado, MA Ciorba, G Bochicchio, O Ilahi, J Kirby, WJ Symons, NO Davidson, MS Levin, DC Rubin
JCI Insight, 2020-12-03;5(23):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence
Authors: VS Adusumilli, TL Walker, RW Overall, GM Klatt, SA Zeidan, S Zocher, DG Kirova, K Ntitsias, TJ Fischer, AM Sykes, S Reinhardt, A Dahl, J Mansfeld, AE Rünker, G Kempermann
Cell Stem Cell, 2020-12-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression
Authors: AL Rocha, TI de Lima, GP de Souza, RO Corrêa, DL Ferrucci, B Rodrigues, C Lopes-Ramo, D Nilsson, TL Knittel, PR Castro, MF Fernandes, F Dos Santos, RB Parmigiani, LR Silveira, HF Carvalho, J Auwerx, MAR Vinolo, J Boucher, MA Mori
Science Advances, 2020-12-02;6(49):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification
Authors: J Qiu, S Nordling, HH Vasavada, EC Butcher, KK Hirschi
Cell Rep, 2020-12-01;33(9):108465.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation
Authors: T Chitiashvi, I Dror, R Kim, FM Hsu, R Chaudhari, E Pandolfi, D Chen, S Liebscher, K Schenke-La, K Plath, A Clark
Nature Cell Biology, 2020-11-30;22(12):1436-1446.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells
Authors: YS Hwang, S Suzuki, Y Seita, J Ito, Y Sakata, H Aso, K Sato, BP Hermann, K Sasaki
Nat Commun, 2020-11-09;11(1):5656.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Molecular basis of CTCF binding polarity in genome folding
Authors: EP Nora, L Caccianini, G Fudenberg, K So, V Kameswaran, A Nagle, A Uebersohn, B Hajj, AL Saux, A Coulon, LA Mirny, KS Pollard, M Dahan, BG Bruneau
Nat Commun, 2020-11-05;11(1):5612.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

R-spondins are BMP receptor antagonists in Xenopus early embryonic development
Authors: H Lee, C Seidl, R Sun, A Glinka, C Niehrs
Nat Commun, 2020-11-04;11(1):5570.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells
Authors: H Fukushima, M Yoshioka, M Kawatou, V López-Dávi, M Takeda, Y Kanda, Y Sekino, Y Yoshida, JK Yamashita
PLoS ONE, 2020-11-02;15(11):e0241287.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells
Authors: FJ Hawkins, S Suzuki, ML Beermann, C Barillà, R Wang, C Villacorta, A Berical, JC Jean, J Le Suer, T Matte, C Simone-Roa, Y Tang, TM Schlaeger, AM Crane, N Matthias, SXL Huang, SH Randell, J Wu, JR Spence, G Carraro, BR Stripp, A Rab, EJ Sorsher, A Horani, SL Brody, BR Davis, DN Kotton
Cell Stem Cell, 2020-10-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
Authors: KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar
Cell Stem Cell, 2020-10-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids
Authors: L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul, AP Carter, LC James, MA Lancaster
Cell Stem Cell, 2020-10-13;0(0):.
Species: Human
Sample Types: Organoid
Applications: Bioassay

Machine learning identifies abnormal Ca2+ transients in human induced pluripotent stem cell-derived cardiomyocytes
Authors: H Hwang, R Liu, JT Maxwell, J Yang, C Xu
Sci Rep, 2020-10-12;10(1):16977.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung
Authors: M Cassandras, C Wang, J Kathiriya, T Tsukui, P Matatia, M Matthay, P Wolters, A Molofsky, D Sheppard, H Chapman, T Peng
Nat Cell Biol, 2020-10-12;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

Development of Colonic Organoids Containing Enteric Nerves or Blood Vessels from Human Embryonic Stem Cells
Authors: CS Park, LP Nguyen, D Yong
Cells, 2020-09-29;9(10):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
Authors: J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Lindstrom-, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton
Cell Stem Cell, 2020-09-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development
Authors: EI Crosse, S Gordon-Key, S Rybtsov, A Binagui-Ca, H Felchle, NC Nnadi, K Kirschner, T Chandra, S Tamagno, DJ Webb, F Rossi, RA Anderson, A Medvinsky
Cell Stem Cell, 2020-09-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2
Authors: F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen
Res Sq, 2020-09-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells
Authors: AFM Dost, AL Moye, M Vedaie, LM Tran, E Fung, D Heinze, C Villacorta, J Huang, R Hekman, JH Kwan, BC Blum, SM Louie, SP Rowbotham, J Sainz de A, ME Piper, PJ Bhetariya, RT Bronson, A Emili, G Mostoslavs, GA Fishbein, WD Wallace, K Krysan, SM Dubinett, J Yanagawa, DN Kotton, CF Kim
Cell Stem Cell, 2020-09-04;27(4):663-678.e8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
Authors: L Han, P Chaturvedi, K Kishimoto, H Koike, T Nasr, K Iwasawa, K Giesbrecht, PC Witcher, A Eicher, L Haines, Y Lee, JM Shannon, M Morimoto, JM Wells, T Takebe, AM Zorn
Nat Commun, 2020-08-27;11(1):4158.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
Authors: L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
Cell Stem Cell, 2020-08-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
Authors: J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton
bioRxiv, 2020-08-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epigenetic regulator function through mouse gastrulation
Authors: S Grosswendt, H Kretzmer, ZD Smith, AS Kumar, S Hetzel, L Wittler, S Klages, B Timmermann, S Mukherji, A Meissner
Nature, 2020-07-29;584(7819):102-108.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration
Authors: AS Ibrahim, K Hussein, F Wang, M Wan, N Saad, M Essa, I Kim, A Shakoor, LA Owen, MM DeAngelis, M Al-Shabraw
J Clin Med, 2020-07-19;9(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming
Authors: P Yan, Z Liu, M Song, Z Wu, W Xu, K Li, Q Ji, S Wang, X Liu, K Yan, CR Esteban, W Ci, JCI Belmonte, W Xie, J Ren, W Zhang, Q Sun, J Qu, GH Liu
Cell Rep, 2020-07-07;32(1):107870.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes Inï¿½Vivo Persistence and Enhances Anti-tumor Activity
Authors: H Zhu, RH Blum, D Bernareggi, EH Ask, Z Wu, HJ Hoel, Z Meng, C Wu, KL Guan, KJ Malmberg, DS Kaufman
Cell Stem Cell, 2020-06-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells
Authors: J Wesely, AG Kotini, F Izzo, H Luo, H Yuan, J Sun, M Georgomano, A Zviran, AG Deslaurier, N Dusaj, SD Nimer, C Leslie, DA Landau, MG Kharas, EP Papapetrou
Cell Rep, 2020-06-02;31(9):107688.
Species: Human
Sample Types:
Applications: Cell Culture

Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells
Authors: K Takahashi, D Jeong, S Wang, M Narita, X Jin, M Iwasaki, SD Perli, BR Conklin, S Yamanaka
Cell Rep, 2020-06-02;31(9):107715.
Species: Mouse
Sample Types:
Applications: Bioassay

Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells
Authors: K Takeishi, A Collin de, Y Wang, K Handa, J Guzman-Lep, K Matsubara, K Morita, S Jang, N Haep, RM Florentino, F Yuan, K Fukumitsu, K Tobita, W Sun, J Franks, ER Delgado, EM Shapiro, NA Fraunhoffe, AW Duncan, H Yagi, T Mashimo, IJ Fox, A Soto-Gutie
Cell Rep, 2020-06-02;31(9):107711.
Species: Human
Sample Types: cell culture

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells
Authors: M Nafria, P Keane, ES Ng, EG Stanley, AG Elefanty, C Bonifer
Cell Rep, 2020-05-26;31(8):107691.
Species: Human
Sample Types:
Applications: Bioassay

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease
Authors: E Giacomelli, V Meraviglia, G Campostrin, A Cochrane, X Cao, RWJ van Helden, A Krotenberg, M Mircea, S Kostidis, RP Davis, BJ van Meer, CR Jost, AJ Koster, H Mei, DG Míguez, AA Mulder, M Ledesma-Te, G Pompilio, L Sala, DCF Salvatori, RC Slieker, E Sommariva, AAF de Vries, M Giera, S Semrau, LGJ Tertoolen, VV Orlova, M Bellin, CL Mummery
Cell Stem Cell, 2020-05-26;26(6):862-879.e11.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes
Authors: H Liang, P Zhang, HJ Bai, J Huang, HT Yang
Stem Cell Res Ther, 2020-05-24;11(1):196.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions
Authors: M Martin-Fer, M Bravo Garc, C Gruber, S Murias Loz, MNH Malik, F Alsohime, A Alakeel, R Valdez, S Buta, G Buda, MA Marti, M Larralde, B Boisson, M Feito Rodr, X Qiu, M Chrabieh, M Al Ayed, S Al Muhsen, JV Desai, EMN Ferre, SD Rosenzweig, B Amador-Bor, LY Bravo-Gall, R Olmer, S Merkert, M Bret, AK Sood, A Al-Rabiaah, MH Temsah, R Halwani, M Hernandez, F Pessler, JL Casanova, J Bustamante, MS Lionakis, D Bogunovic
Cell Rep, 2020-05-12;31(6):107633.
Species: Human
Sample Types:
Applications: Bioassay

Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation
Authors: M Grosch, S Ittermann, E Rusha, T Greisle, C Ori, DJ Truong, AC O'Neill, A Pertek, GG Westmeyer, M Drukker
BMC Biol., 2020-04-22;18(1):42.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration
Authors: A Krouwels, JD Iljas, AHM Kragten, WJA Dhert, FC Öner, MA Tryfonidou, LB Creemers
Int J Mol Sci, 2020-04-14;21(8):.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Generation of human oogonia from induced pluripotent stem cells in culture
Authors: C Yamashiro, K Sasaki, S Yokobayash, Y Kojima, M Saitou
Nat Protoc, 2020-03-30;15(4):1560-1583.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cabozantinib Reverses Renal Cell Carcinoma-Mediated Osteoblast Inhibition in Three-Dimensional Co-culture In Vitro and Reduces Bone Osteolysis In Vivo
Authors: T Pan, M Martinez, KM Hubka, JH Song, SC Lin, G Yu, YC Lee, GE Gallick, SM Tu, DA Harrington, MC Farach-Car, SH Lin, RL Satcher
Mol. Cancer Ther., 2020-03-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells
Authors: JL Hu, H Liang, H Zhang, MZ Yang, W Sun, P Zhang, L Luo, JX Feng, H Bai, F Liu, T Zhang, JY Yang, Q Gao, Y Long, XY Ma, Y Chen, Q Zhong, B Yu, S Liao, Y Wang, Y Zhao, MS Zeng, N Cao, J Wang, W Chen, HT Yang, S Gao
Nucleic Acids Res., 2020-03-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
Authors: NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman
Nat. Biotechnol., 2020-02-24;0(0):.
Species: Human
Sample Types: cell culture
Applications: Cell Culture

Chromosome 19 microRNA cluster enhances cell reprogramming by inhibiting epithelial-to-mesenchymal transition
Authors: EF Mong, Y Yang, KM Akat, J Canfield, J VanWye, J Lockhart, JCM Tsibris, F Schatz, CJ Lockwood, T Tuschl, UA Kayisli, H Totary-Jai
Sci Rep, 2020-02-20;10(1):3029.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist
Authors: M Riedl, C Witzmann, M Koch, S Lang, M Kerschbaum, F Baumann, W Krutsch, D Docheva, V Alt, C Pfeifer
Int J Mol Sci, 2020-02-20;21(4):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

PPAR&gamma and PPAR&alpha synergize to induce robust browning of white fat inï¿½vivo
Authors: T Kroon, M Harms, S Maurer, L Bonnet, I Alexanders, A Lindblom, A Ahnmark, D Nilsson, P Gennemark, G O'Mahony, V Osinski, C McNamara, J Boucher
Mol Metab, 2020-02-18;36(0):100964.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells
Authors: Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban
Nat. Immunol., 2020-02-17;21(3):274-286.
Species: Human
Sample Types: Cells
Applications: Cell Culture

Generation of a Quantitative Luciferase Reporter for Sox9 SUMOylation
Authors: H Saotome, A Ito, A Kubo, M Inui
Int J Mol Sci, 2020-02-13;21(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ER stress reliever enhances functionalities of in vitro cultured hepatocytes
Authors: JS Kim, SI Hwang, JL Ryu, HS Hong, JM Lee, SM Lee, X Jin, C Han, JH Kim, J Han, MR Lee, DH Woo
Stem Cell Res, 2020-02-12;43(0):101732.
Species: Human
Sample Types: cell culture
Applications: Bioassay

Generation and validation of a PITX2-EGFP reporter line of human induced pluripotent stem cells enables isolation of periocular mesenchymal cells
Authors: T Okubo, R Hayashi, S Shibata, Y Kudo, Y Ishikawa, S Inoue, Y Kobayashi, A Honda, Y Honma, S Kawasaki, K Nishida
J. Biol. Chem., 2020-02-07;295(11):3456-3465.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures
Authors: A Sridhar, A Hoshino, CR Finkbeiner, A Chitsazan, L Dai, AK Haugan, KM Eschenbach, DL Jackson, C Trapnell, O Bermingham, I Glass, TA Reh
Cell Rep, 2020-02-04;30(5):1644-1659.e4.
Species: Human
Sample Types: Embryoid Bodies
Applications: Bioassay

Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells
Authors: R Matsumoto, H Suga, T Aoi, H Bando, H Fukuoka, G Iguchi, S Narumi, T Hasegawa, K Muguruma, W Ogawa, Y Takahashi
J. Clin. Invest., 2020-02-03;130(2):641-654.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca)
Authors: A Horváth, T Christ, JT Koivumäki, M Prondzynsk, ATL Zech, M Spohn, U Saleem, I Mannhardt, B Ulmer, E Girdauskas, C Meyer, A Hansen, T Eschenhage, MD Lemoine
Cells, 2020-01-20;9(1):.
Species: Human
Sample Types: Organoid
Applications: Bioassay

Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells
Authors: W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho
Stem Cells, 2019-12-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors
Authors: D Chen, N Sun, L Hou, R Kim, J Faith, M Aslanyan, Y Tao, Y Zheng, J Fu, W Liu, M Kellis, A Clark
Cell Rep, 2019-12-24;29(13):4568-4582.e5.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue
Authors: A Kuwahara, S Yamasaki, M Mandai, K Watari, K Matsushita, M Fujiwara, Y Hori, Y Hiramine, D Nukaya, M Iwata, A Kishino, M Takahashi, Y Sasai, T Kimura
Sci Rep, 2019-12-12;9(1):18936.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NKL homeobox gene activities in normal and malignant myeloid cells
Authors: S Nagel, M Scherr, RAF MacLeod, C Pommerenke, M Koeppel, C Meyer, M Kaufmann, I Dallmann, HG Drexler
PLoS ONE, 2019-12-11;14(12):e0226212.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype
Authors: F Roudnicky, Y Lan, M Friesen, G Dernick, JD Zhang, A Staempfli, N Bordag, A Wagner-Gol, K Christense, M Ebeling, M Graf, M Burcin, CA Meyer, CA Cowan, C Patsch
Int J Mol Sci, 2019-12-09;20(24):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies
Authors: M Ali, F Kabir, JJ Thomson, Y Ma, C Qiu, M Delannoy, SY Khan, SA Riazuddin
Sci Rep, 2019-12-06;9(1):18552.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential
Authors: A Sahabian, M Sgodda, O Naujok, R Dettmer, J Dahlmann, F Manstein, T Cantz, R Zweigerdt, U Martin, R Olmer
Cells, 2019-12-04;8(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Supplementation of vitamin C promotes early germ cell specification from human embryonic stem cells
Authors: Z Li, F Fang, Q Zhao, H Li, C Xiong
Stem Cell Res Ther, 2019-11-15;10(1):324.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells
Authors: A Jacob, M Vedaie, DA Roberts, DC Thomas, C Villacorta, KD Alysandrat, F Hawkins, DN Kotton
Nat Protoc, 2019-11-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway
Authors: D Seo, SM Jung, JS Park, J Lee, J Ha, M Kim, SH Park
EBioMedicine, 2019-11-01;49(0):55-71.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation
Authors: GL Tiemeier, G Wang, SJ Dumas, WMPJ Sol, MC Avramut, T Karakach, VV Orlova, CW van den Be, CL Mummery, P Carmeliet, BM van den Be, TJ Rabelink
Stem Cell Reports, 2019-10-31;13(5):803-816.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations
Authors: J Grajcarek, J Monlong, Y Nishinaka-, M Nakamura, M Nagai, S Matsuo, D Lougheed, H Sakurai, MK Saito, G Bourque, K Woltjen
Nat Commun, 2019-10-24;10(1):4856.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells
Authors: A Stubb, C Guzmán, E Närvä, J Aaron, TL Chew, M Saari, M Miihkinen, G Jacquemet, J Ivaska
Nat Commun, 2019-10-18;10(1):4756.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma
Authors: R Sachdeva, M Wu, K Johnson, H Kim, A Celebre, U Shahzad, MS Graham, JA Kessler, JH Chuang, J Karamchand, M Bredel, R Verhaak, S Das
Sci Rep, 2019-10-10;9(1):14569.
Species: Human
Sample Types: Whole Cells
Applications: Tissue Culture

Engineering transferrable microvascular meshes for subcutaneous islet transplantation
Authors: W Song, A Chiu, LH Wang, RE Schwartz, B Li, N Bouklas, DT Bowers, D An, SH Cheong, JA Flanders, Y Pardo, Q Liu, X Wang, VK Lee, G Dai, M Ma
Nat Commun, 2019-10-10;10(1):4602.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant
Authors: V Veschi, LR Mangiapane, A Nicotra, S Di Franco, E Scavo, T Apuzzo, DS Sardina, M Fiori, A Benfante, ML Colorito, G Cocorullo, F Giuliante, C Cipolla, G Pistone, MR Bongiorno, A Rizzo, CM Tate, X Wu, S Rowlinson, LF Stancato, M Todaro, R De Maria, G Stassi
Oncogene, 2019-10-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation
Authors: Q Mei, A Bansal, MKG Jayakumar, Z Zhang, J Zhang, H Huang, D Yu, CJA Ramachandr, DJ Hausenloy, TW Soong, Y Zhang
Nat Commun, 2019-09-27;10(1):4416.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Controlled modelling of human epiblast and amnion development using stem cells
Authors: Y Zheng, X Xue, Y Shao, S Wang, SN Esfahani, Z Li, JM Muncie, JN Lakins, VM Weaver, DL Gumucio, J Fu
Nature, 2019-09-11;573(7774):421-425.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology
Authors: S Yoshimatsu, T Sone, M Nakajima, T Sato, R Okochi, M Ishikawa, M Nakamura, E Sasaki, S Shiozawa, H Okano
PLoS ONE, 2019-08-27;14(8):e0221164.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SMYD2 Drives Mesendodermal Differentiation of Human Embryonic Stem Cells through Mediating the Transcriptional Activation of Key Mesendodermal Genes
Authors: HJ Bai, P Zhang, L Ma, H Liang, G Wei, HT Yang
Stem Cells, 2019-08-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
Authors: JM Segal, D Kent, DJ Wesche, SS Ng, M Serra, B Oulès, G Kar, G Emerton, SJI Blackford, S Darmanis, R Miquel, TV Luong, R Yamamoto, A Bonham, W Jassem, N Heaton, A Vigilante, A King, R Sancho, S Teichmann, SR Quake, H Nakauchi, ST Rashid
Nat Commun, 2019-07-26;10(1):3350.
Species: Human
Sample Types: Organoid
Applications: Bioassay

Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells
Authors: C Song, F Xu, Z Ren, Y Zhang, Y Meng, Y Yang, S Lingadahal, E Cheung, G Li, W Liu, J Wan, Y Zhao, G Chen
Stem Cell Reports, 2019-07-25;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model
Authors: S Pecha, K Yorgan, M Röhl, B Geertz, A Hansen, F Weinberger, S Sehner, H Ehmke, H Reichenspu, T Eschenhage, AP Schwoerer
Sci Rep, 2019-07-08;9(1):9831.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients
Authors: M Nasri, M Ritter, P Mir, B Dannenmann, N Aghaallaei, D Amend, V Makaryan, Y Xu, B Fletcher, R Bernhard, I Steiert, K Hahnel, J Berger, I Koch, B Sailer, K Hipp, C Zeidler, M Klimiankou, B Bajoghli, DC Dale, K Welte, J Skokowa
Haematologica, 2019-06-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition.
Authors: Ohta R, Sugimura R, Niwa A, Saito M
J Vis Exp, 2019-06-16;0(148):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea
Authors: M Prajapati-, A Benito-Gon, EJ Golden, S Zhang, A Doetzlhofe
Elife, 2019-06-12;8(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Adequate taylor couette flow-mediated shear stress is useful for dissociating human iPS cell-derived cell aggregates
Authors: K Matsuura, M Wada, K Sakaguchi, Y Matsuhashi, T Shimizu
Regen Ther, 2019-04-25;12(0):6-13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development
Authors: RMJ Genga, EM Kernfeld, KM Parsi, TJ Parsons, MJ Ziller, R Maehr
Cell Rep, 2019-04-16;27(3):708-718.e10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Noggin depletion in adipocytes promotes obesity in mice
Authors: AM Blázquez-M, M Jumabay, P Rajbhandar, T Sallam, Y Guo, J Yao, L Vergnes, K Reue, L Zhang, Y Yao, AM Fogelman, P Tontonoz, AJ Lusis, X Wu, KI Boström
Mol Metab, 2019-04-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
Authors: B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat
Cell Rep, 2019-04-09;27(2):599-615.e12.
Species: Human
Sample Types: cell culture
Applications: Differentiation, Differentiation

Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes
Authors: K Sattler, I El-Battraw, Z Zhao, C Schrottenb, G Yücel, H Lan, X Li, S Lang, WH Zimmermann, L Cyganek, J Utikal, T Wieland, U Ravens, K Bieback, M Borggrefe, X Zhou, I Akin
Sci Rep, 2019-04-04;9(1):5651.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes
Authors: MJ Harms, Q Li, S Lee, C Zhang, B Kull, S Hallen, A Thorell, I Alexanders, CE Hagberg, XR Peng, A Mardinoglu, KL Spalding, J Boucher
Cell Rep, 2019-04-02;27(1):213-225.e5.
Species: Human
Sample Types: Tissue Explants
Applications: Bioassay

Derivation of enteric neuron lineages from human pluripotent stem cells
Authors: K Barber, L Studer, F Fattahi
Nat Protoc, 2019-03-25;14(4):1261-1279.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia
Authors: H Okada, C Nakanishi, S Yoshida, M Shimojima, J Yokawa, M Mori, H Tada, T Yoshimuta, K Hayashi, T Yamano, R Hanayama, M Yamagishi, MA Kawashiri
Sci Rep, 2019-03-18;9(1):4695.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
Authors: H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta
Cell Stem Cell, 2019-03-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Synchrony and asynchrony between an epigenetic clock and developmental timing
Authors: A Hoshino, S Horvath, A Sridhar, A Chitsazan, TA Reh
Sci Rep, 2019-03-06;9(1):3770.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse
Authors: AD Senft, EK Bikoff, EJ Robertson, I Costello
Nat Commun, 2019-03-06;10(1):1089.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

FGF signal is not required for hepatoblast differentiation of human iPS cells
Authors: Y Toba, A Kiso, S Nakamae, F Sakurai, K Takayama, H Mizuguchi
Sci Rep, 2019-03-06;9(1):3713.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair
Authors: T Colunga, M Hayworth, S Kre beta, DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton
Cell Rep, 2019-03-05;26(10):2566-2579.e10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Feather arrays are patterned by interacting signalling and cell density waves
Authors: WKW Ho, L Freem, D Zhao, KJ Painter, TE Woolley, EA Gaffney, MJ McGrew, A Tzika, MC Milinkovit, P Schneider, A Drusko, F Matthäus, JD Glover, KL Wells, JA Johansson, MG Davey, HM Sang, M Clinton, DJ Headon
PLoS Biol., 2019-02-21;17(2):e3000132.
Species: Chicken
Sample Types: Tissue Explants
Applications: Bioassay

Autonomous trisomic rescue of Down syndrome cells
Authors: M Inoue, K Kajiwara, A Yamaguchi, T Kiyono, O Samura, H Akutsu, H Sago, A Okamoto, A Umezawa
Lab. Invest., 2019-02-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application
Authors: E Ito, S Miyagawa, M Takeda, A Kawamura, A Harada, H Iseoka, S Yajima, N Sougawa, N Mochizuki-, S Yasuda, Y Sato, Y Sawa
Sci Rep, 2019-02-13;9(1):1881.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells
Authors: Y Yan, J Bejoy, J Xia, K Griffin, J Guan, Y Li
Sci Rep, 2019-02-04;9(1):1295.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Orexin A modulates prolactin production by regulating BMP-4 activity in rat pituitary lactotorope cells
Authors: S Fujisawa, M Komatsubar, K Ogura-Ochi, N Tsukamoto-, K Toma, K Inagaki, J Wada, F Otsuka
Peptides, 2019-02-02;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment
Authors: L Li, Y Wang, JL Torkelson, G Shankar, JM Pattison, HH Zhen, F Fang, Z Duren, J Xin, S Gaddam, SP Melo, SN Piekos, J Li, EJ Liaw, L Chen, R Li, M Wernig, WH Wong, HY Chang, AE Oro
Cell Stem Cell, 2019-01-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells
Authors: A Montel-Hag, CS Seet, S Li, B Chick, Y Zhu, P Chang, S Tsai, V Sun, S Lopez, HC Chen, C He, CJ Chin, D Casero, GM Crooks
Cell Stem Cell, 2019-01-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration
Authors: P Yan, Q Li, L Wang, P Lu, K Suzuki, Z Liu, J Lei, W Li, X He, S Wang, J Ding, P Chan, W Zhang, M Song, JC Izpisua Be, J Qu, F Tang, GH Liu
Cell Stem Cell, 2019-01-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds
Authors: STJ Bradford, EJ Ranghini, E Grimley, PH Lee, GR Dressler
J. Biol. Chem., 2019-01-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of human antral and fundic gastric organoids from pluripotent stem cells
Authors: TR Broda, KW McCracken, JM Wells
Nat Protoc, 2019-01-01;14(1):28-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation
Authors: D Chen, W Liu, J Zimmerman, WA Pastor, R Kim, L Hosohama, J Ho, M Aslanyan, JJ Gell, SE Jacobsen, AT Clark
Cell Rep, 2018-12-26;25(13):3591-3602.e5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs
Authors: S Frank, G Ahuja, D Bartsch, N Russ, W Yao, JC Kuo, JP Derks, VS Akhade, Y Kargapolov, T Georgomano, JE Messling, M Gramm, L Brant, R Rehimi, NE Vargas, A Kuroczik, TP Yang, RGA Sahito, J Franzen, J Hescheler, A Sachinidis, M Peifer, A Rada-Igles, M Kanduri, IG Costa, C Kanduri, A Papantonis, L Kurian
Cell Stem Cell, 2018-12-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys
Authors: Y Kang, Z Ai, K Duan, C Si, Y Wang, Y Zheng, J He, Y Yin, S Zhao, B Niu, X Zhu, L Liu, L Xiang, L Zhang, Y Niu, W Ji, T Li
Cell Rep, 2018-11-27;25(9):2563-2576.e9.
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis
Authors: CC Weng, PY Ding, YH Liu, JR Hawse, M Subramania, CC Wu, YC Lin, CY Chen, WC Hung, KH Cheng
Oncogene, 2018-11-22;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping
Authors: P Ray, AS Chin, KE Worley, J Fan, G Kaur, M Wu, LQ Wan
Proc. Natl. Acad. Sci. U.S.A., 2018-11-20;0(0):.
Species: Chicken
Sample Types: Embryo
Applications: Bioassay

Barrier properties and transcriptome expression in human iPSC-derived models of the blood-brain barrier
Authors: L Delsing, P Dönnes, J Sánchez, M Clausen, D Voulgaris, A Falk, A Herland, G Brolén, H Zetterberg, R Hicks, J Synnergren
Stem Cells, 2018-11-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment
Authors: JM Pattison, SP Melo, SN Piekos, JL Torkelson, E Bashkirova, MR Mumbach, C Rajasingh, HH Zhen, L Li, E Liaw, D Alber, AJ Rubin, G Shankar, X Bao, HY Chang, PA Khavari, AE Oro
Nat. Genet., 2018-11-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits
Authors: JGW Smith, T Owen, JR Bhagwan, D Mosqueira, E Scott, I Mannhardt, A Patel, R Barriales-, L Monserrat, A Hansen, T Eschenhage, SE Harding, S Marston, C Denning
Stem Cell Reports, 2018-11-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing
Authors: SS Adkar, CL Wu, VP Willard, A Dicks, A Ettyreddy, N Steward, N Bhutani, CA Gersbach, F Guilak
Stem Cells, 2018-10-31;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
Authors: A Yoney, F Etoc, A Ruzo, T Carroll, JJ Metzger, I Martyn, S Li, C Kirst, ED Siggia, AH Brivanlou
Elife, 2018-10-12;7(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa
Authors: A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-, D Dolan, A Droop, J Collin, R Bronstein, S Mehrotra, M Farkas, G Hilgen, K White, KT Pan, A Treumann, D Hallam, K Bialas, G Chung, C Mellough, Y Ding, N Krasnogor, S Przyborski, S Zwolinski, J Al-Aama, S Alharthi, Y Xu, G Wheway, K Szymanska, M McKibbin, CF Inglehearn, DJ Elliott, S Lindsay, RR Ali, DH Steel, L Armstrong, E Sernagor, H Urlaub, E Pierce, R Lührmann, SN Grellschei, CA Johnson, M Lako
Nat Commun, 2018-10-12;9(1):4234.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling
Authors: Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que
Cell Stem Cell, 2018-09-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition
Authors: K Kirino, T Nakahata, T Taguchi, MK Saito
Sci Rep, 2018-08-27;8(1):12865.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming
Authors: AD Senft, I Costello, HW King, AW Mould, EK Bikoff, EJ Robertson
Cell Rep, 2018-08-21;24(8):1977-1985.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids
Authors: A Di Baldass, MA D'Amico, P Izzicupo, G Gaggi, S Guarnieri, MA Mariggiò, I Antonucci, B Corneo, D Sirabella, L Stuppia, B Ghinassi
Sci Rep, 2018-08-13;8(1):12028.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Analysis of differentially expressed genes among human hair follicle-derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes
Authors: Z Xu, X He, X Shi, Y Xia, X Liu, H Wu, P Li, H Zhang, W Yin, X Du, L Li, Y Li
Stem Cell Res Ther, 2018-08-09;9(1):211.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induced pluripotent stem cell line from an atopic dermatitis patient heterozygous for c.2282del4 mutation in filaggrin: KCLi001-A
Authors: L Devito, M Donne, N Kolundzic, P Khurana, C Hobbs, G Kaddour, S Dubrac, R Gruber, M Schmuth, T Mauro, D Ilic
Stem Cell Res, 2018-07-25;31(0):122-126.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids
Authors: E Magro-Lope, C Palmer, J Manso, I Liste, A Zambrano
Stem Cell Res Ther, 2018-07-11;9(1):186.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
Authors: K Koefoed, J Skat-Rørda, P Andersen, CB Warzecha, M Pye, TA Andersen, KD Ajbro, E Bendsen, M Narimatsu, F Vilhardt, LB Pedersen, JL Wrana, RH Anderson, K Møllgård, ST Christense, LA Larsen
Sci Rep, 2018-06-22;8(1):9542.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages
Authors: J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao
Cell Transplant, 2018-06-13;0(0):9636897187803.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling
Authors: H Jun, H Yu, J Gong, J Jiang, X Qiao, E Perkey, DI Kim, MP Emont, AG Zestos, JS Cho, J Liu, RT Kennedy, I Maillard, XZS Xu, J Wu
Nat. Med., 2018-05-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis
Authors: X Guo, Y Xu, Z Wang, Y Wu, J Chen, G Wang, C Lu, W Jia, J Xi, S Zhu, Z Jiapaer, X Wan, Z Liu, S Gao, J Kang
Cell Stem Cell, 2018-05-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage
Authors: V Pursani, D Bhartiya, V Tanavde, M Bashir, P Sampath
Stem Cell Res Ther, 2018-04-10;9(1):97.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA
Authors: YC Chen, CL Tsai, YH Wei, YT Wu, WT Hsu, HC Lin, YC Hsu
Cell Death Dis, 2018-04-01;9(4):437.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery
Authors: Y Jin, Y Liu, Z Li, K Santostefa, J Shi, X Zhang, D Wu, Z Cheng, W Wu, N Terada, S Jin, F Bai
PLoS ONE, 2018-03-26;13(3):e0194895.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Simplified footprint-free Cas9/CRISPR editing of cardiac-associated genes in human pluripotent stem cells
Authors: A Kondrashov, M Duc Hoang, J Smith, J Bhagwan, G Duncan, D Mosqueira, M Munoz, NTN Vo, C Denning
Stem Cells Dev., 2018-03-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial-venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells
Authors: JS Esser, RE Steiner, M Deckler, H Schmitt, B Engert, S Link, A Charlet, C Patterson, C Bode, Q Zhou, M Moser
FEBS J., 2018-03-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Beta-Catenin maintains lung epithelial progenitors after lung specification
Authors: EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen
Development, 2018-03-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency
Authors: RA Sierra, NP Hoverter, RN Ramirez, LM Vuong, A Mortazavi, BJ Merrill, ML Waterman, PJ Donovan
Development, 2018-02-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype
Authors: F Wang, V Zachar, CP Pennisi, T Fink, Y Maeda, J Emmersen
Int J Mol Sci, 2018-02-08;19(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B
Authors: R Okamoto, K Takayama, N Akita, Y Nagamoto, D Hosokawa, S Iizuka, F Sakurai, H Suemizu, K Ohashi, H Mizuguchi
Cell Transplant, 2018-02-01;27(2):299-309.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells
Authors: T Yamashita, K Takayama, F Sakurai, H Mizuguchi
Biochem. Biophys. Res. Commun., 2018-02-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing
Authors: C Long, H Li, M Tiburcy, C Rodriguez-, V Kyrychenko, H Zhou, Y Zhang, YL Min, JM Shelton, PPA Mammen, NY Liaw, WH Zimmermann, R Bassel-Dub, JW Schneider, EN Olson
Sci Adv, 2018-01-31;4(1):eaap9004.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions
Authors: A Yachie-Kin, K Onishi, J Ostblom, MA Langley, E Posfai, J Rossant, PW Zandstra
Mol. Syst. Biol., 2018-01-29;14(1):e7952.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps
Authors: L Tengroth, J Arebro, O Larsson, C Bachert, SK Georén, LO Cardell
Sci Rep, 2018-01-24;8(1):1561.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation
Authors: JJ Gell, J Zhao, D Chen, TJ Hunt, AT Clark
Stem Cell Res, 2018-01-04;27(0):46-56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rapid DNA replication origin licensing protects stem cell pluripotency
Authors: JP Matson, R Dumitru, P Coryell, RM Baxley, W Chen, K Twaroski, BR Webber, J Tolar, AK Bielinsky, JE Purvis, JG Cook
Elife, 2017-11-17;6(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
Authors: A Taguchi, R Nishinakam
Cell Stem Cell, 2017-11-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium
Authors: J Li, I Minami, M Shiozaki, L Yu, S Yajima, S Miyagawa, Y Shiba, N Morone, S Fukushima, M Yoshioka, S Li, J Qiao, X Li, L Wang, H Kotera, N Nakatsuji, Y Sawa, Y Chen, L Liu
Stem Cell Reports, 2017-10-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency
Authors: C Krendl, D Shaposhnik, V Rishko, C Ori, C Ziegenhain, S Sass, L Simon, NS Müller, T Straub, KE Brooks, SL Chavez, W Enard, FJ Theis, M Drukker
Proc. Natl. Acad. Sci. U.S.A., 2017-10-25;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A right-handed signalling pathway drives heart looping in vertebrates
Authors: OH Ocaña, H Coskun, C Minguillón, P Murawala, EM Tanaka, J Galcerán, R Muñoz-Cháp, MA Nieto
Nature, 2017-09-06;549(7670):86-90.
Species: Zebrafish
Sample Types: Whole Tissue
Applications: Bioassay

Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium
Authors: N Yucer, M Holzapfel, T Jenkins Vo, L Lenaeus, L Ornelas, A Laury, D Sareen, R Barrett, BY Karlan, CN Svendsen
Sci Rep, 2017-09-06;7(1):10741.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics
Authors: NG Kooreman, PE de Almeida, JP Stack, RV Nelakanti, S Diecke, NY Shao, RJ Swijnenbur, V Sanchez-Fr, E Matsa, C Liu, AJ Connolly, JF Hamming, PHA Quax, MA Brehm, DL Greiner, LD Shultz, JC Wu
Cell Rep, 2017-08-22;20(8):1978-1990.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In Vitro Micropatterned Human Pluripotent Stem Cell Test (ï¿½P-hPST) for Morphometric-Based Teratogen Screening
Authors: J Xing, Y Cao, Y Yu, H Li, Z Song, H Yu
Sci Rep, 2017-08-17;7(1):8491.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis
Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
Cell Rep, 2017-08-15;20(7):1597-1608.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion
Authors: R McLennan, CM Bailey, LJ Schumacher, JM Teddy, JA Morrison, JC Kasemeier-, LA Wolfe, MM Gogol, RE Baker, PK Maini, PM Kulesa
J. Cell Biol., 2017-08-15;216(10):3339-3354.
Species: Chicken, Human
Sample Types: Whole Cells
Applications: Bioassay

A pluripotent stem cell-based model for post-implantation human amniotic sac development
Authors: Y Shao, K Taniguchi, RF Townshend, T Miki, DL Gumucio, J Fu
Nat Commun, 2017-08-08;8(1):208.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1?
Authors: KM Tsang, JS Hyun, KT Cheng, M Vargas, D Mehta, M Ushio-Fuka, L Zou, KV Pajcini, J Rehman, AB Malik
Stem Cell Reports, 2017-08-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations
Authors: JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller
Cell Stem Cell, 2017-08-03;21(2):179-194.e4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells
Authors: C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat
J. Biol. Chem., 2017-07-26;0(0):.
Species: Human, Mouse
Sample Types: Recombinant Protein, Whole Cells
Applications: Bioassay

Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2
Authors: P Scerbo, L Marchal, L Kodjabachi
Elife, 2017-06-27;6(0):.
Species: Xenopus
Sample Types: In Vivo
Applications: In Vivo

Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate
Authors: AG Freire, A Waghray, F Soares-da-, TP Resende, DF Lee, CF Pereira, DS Nascimento, IR Lemischka, P Pinto-do-Ó
Stem Cell Reports, 2017-06-22;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Induced pluripotent stem cell-derived limbal epithelial cells (LiPSC) as a cellular alternative for in vitro ocular toxicity testing
Authors: E Aberdam, I Petit, L Sangari, D Aberdam
PLoS ONE, 2017-06-22;12(6):e0179913.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
Authors: A Campbell, JM Hogestyn, CJ Folts, B Lopez, C Pröschel, D Mock, M Mayer-Prös
Sci Rep, 2017-06-21;7(1):3978.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells
Authors: K Ogura-Ochi, S Fujisawa, N Iwata, M Komatsubar, Y Nishiyama, N Tsukamoto-, K Inagaki, J Wada, F Otsuka
Peptides, 2017-06-13;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells
Authors: D Jung, J Xiong, M Ye, X Qin, L Li, S Cheng, M Luo, J Peng, J Dong, F Tang, W Shen, MM Matzuk, K Kee
Nat Commun, 2017-06-12;8(0):15680.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes
Authors: G Yücel, Z Zhao, I El-Battraw, H Lan, S Lang, X Li, F Buljubasic, WH Zimmermann, L Cyganek, J Utikal, U Ravens, T Wieland, M Borggrefe, XB Zhou, I Akin
Sci Rep, 2017-06-07;7(1):2935.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells
Authors: K Kajiwara, T Tanemoto, S Wada, J Karibe, N Ihara, Y Ikemoto, T Kawasaki, Y Oishi, O Samura, K Okamura, S Takada, H Akutsu, H Sago, A Okamoto, A Umezawa
Stem Cell Reports, 2017-06-06;8(6):1701-1713.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols
Authors: D Jeziorowsk, V Fontaine, C Jouve, E Villard, S Dussaud, D Akbar, V Letang, P Cervello, JM Itier, MP Pruniaux, JS Hulot
Int J Mol Sci, 2017-06-01;18(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pericyte-derived Bone Morphogenetic Protein 4 Underlies White Matter Damage after Chronic Hypoperfusion
Authors: MT Uemura, M Ihara, T Maki, T Nakagomi, S Kaji, K Uemura, T Matsuyama, RN Kalaria, A Kinoshita, R Takahashi
Brain Pathol., 2017-05-31;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence
Authors: N Rahman, PM Brauer, L Ho, T Usenko, M Tewary, JC Zúñiga-Pfl, PW Zandstra
Nat Commun, 2017-05-25;8(0):15380.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induction of senescence in primary glioblastoma cells by serum and TGF?
Authors: R Kumar, A Gont, TJ Perkins, JEL Hanson, IAJ Lorimer
Sci Rep, 2017-05-19;7(1):2156.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differentiation of cardiomyocytes and generation of human engineered heart tissue
Authors: K Breckwoldt, D Letuffe-Br, I Mannhardt, T Schulze, B Ulmer, T Werner, A Benzin, B Klampe, MC Reinsch, S Laufer, A Shibamiya, M Prondzynsk, G Mearini, D Schade, S Fuchs, C Neuber, E Krämer, U Saleem, ML Schulze, ML Rodriguez, T Eschenhage, A Hansen
Nat Protoc, 2017-05-11;12(6):1177-1197.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5
Authors: LK Bollum, K Huse, MP Oksvold, B Bai, VI Hilden, L Forfang, SO Yoon, S Wälchli, EB Smeland, JH Myklebust
PLoS ONE, 2017-05-10;12(5):e0177188.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells
Authors: F Hawkins, P Kramer, A Jacob, I Driver, DC Thomas, KB McCauley, N Skvir, AM Crane, AA Kurmann, AN Hollenberg, S Nguyen, BG Wong, AS Khalil, SX Huang, S Guttentag, JR Rock, JM Shannon, BR Davis, DN Kotton
J. Clin. Invest., 2017-05-02;127(6):2277-2294.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells
Authors: E Raja, A Komuro, R Tanabe, S Sakai, Y Ino, N Saito, T Todo, M Morikawa, H Aburatani, D Koinuma, C Iwata, K Miyazono
Oncogene, 2017-05-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System
Authors: K Low, LY Wong, M Maldonado, C Manjunath, CB Horner, M Perez, NV Myung, J Nam
Stem Cell Reports, 2017-04-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling
Authors: S Mitani, K Takayama, Y Nagamoto, K Imagawa, F Sakurai, M Tachibana, R Sumazaki, H Mizuguchi
Mol. Ther., 2017-04-24;25(6):1420-1433.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Direct comparison of distinct naive pluripotent states in human embryonic stem cells
Authors: S Warrier, M Van der Je, G Duggal, L Tilleman, E Sutherland, J Taelman, M Popovic, S Lierman, S Chuva De S, A Van Soom, L Peelman, F Van Nieuwe, DIM De Coninck, B Menten, P Mestdagh, J Van de Som, D Deforce, P De Sutter, B Heindryckx
Nat Commun, 2017-04-21;8(0):15055.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Recapitulating and Correcting Marfan Syndrome in a Cellular Model
Authors: JW Park, L Yan, C Stoddard, X Wang, Z Yue, L Crandall, T Robinson, Y Chang, K Denton, E Li, B Jiang, Z Zhang, K Martins-Ta, SP Yee, H Nie, F Gu, W Si, T Xie, L Yue, RH Xu
Int. J. Biol. Sci., 2017-04-10;13(5):588-603.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gelatin device for the delivery of growth factors involved in endochondral ossification
Authors: LA Ahrens, D Vonwil, J Christense, VP Shastri
PLoS ONE, 2017-04-05;12(4):e0175095.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection
Authors: F Sakurai, S Mitani, T Yamamoto, K Takayama, M Tachibana, K Watashi, T Wakita, S Iijima, Y Tanaka, H Mizuguchi
Sci Rep, 2017-04-04;7(0):45698.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency
Authors: JH Lee, S Laronde, TJ Collins, Z Shapovalov, B Tanasijevi, JD McNicol, A Fiebig-Com, YD Benoit, JB Lee, RR Mitchell, M Bhatia
Cell Rep, 2017-04-04;19(1):20-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Supraphysiological levels of GDF11 induce striated muscle atrophy
Authors: DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney
EMBO Mol Med, 2017-04-01;0(0):.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
Authors: KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
Cell Stem Cell, 2017-03-30;0(0):.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Serum Proteases Potentiate BMP-Induced Cell Cycle Re-entry of Dedifferentiating Muscle Cells during Newt Limb Regeneration
Authors: I Wagner, H Wang, PM Weissert, WL Straube, A Shevchenko, M Gentzel, G Brito, A Tazaki, C Oliveira, T Sugiura, A Shevchenko, A Simon, DN Drechsel, EM Tanaka
Dev. Cell, 2017-03-27;40(6):608-617.e6.
Applications: Western Blot

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells
Authors: F Sampazioti, MC de Brito, I Geti, A Bertero, NR Hannan, L Vallier
Nat Protoc, 2017-03-23;12(4):814-827.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine
Authors: BW Ellis, A Acun, UI Can, P Zorlutuna
Biomicrofluidics, 2017-03-16;11(2):024105.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells
Authors: Y Tachida, N Izumi, T Sakurai, H Kobayashi
Biol Open, 2017-03-15;6(3):370-380.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells
Authors: E Giacomelli, M Bellin, L Sala, BJ van Meer, LG Tertoolen, VV Orlova, CL Mummery
Development, 2017-03-15;144(6):1008-1017.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Efficient production of trophoblast lineage cells from human induced pluripotent stem cells
Authors: J Kojima, A Fukuda, H Taira, T Kawasaki, H Ito, N Kuji, K Isaka, A Umezawa, H Akutsu
Lab. Invest, 2017-03-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Highly Efficient Differentiation of Endothelial Cells from Pluripotent Stem Cells Requires the MAPK and the PI3K Pathways
Authors: A Harding, E Cortez-Tol, NL Magner, JR Beegle, DP Coleal-Ber, D Hao, A Wang, JA Nolta, P Zhou
Stem Cells, 2017-03-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inï¿½Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling
Authors: K Yamamizu, M Iwasaki, H Takakubo, T Sakamoto, T Ikuno, M Miyoshi, T Kondo, Y Nakao, M Nakagawa, H Inoue, JK Yamashita
Stem Cell Reports, 2017-02-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nutritional modulation of mouse and human liver bud growth through a branched-amino acid metabolism
Authors: H Koike, RR Zhang, Y Ueno, K Sekine, YW Zheng, T Takebe, H Taniguchi
Development, 2017-02-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia
Authors: AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, A Solovyov, C Husser, M Olszewska, J Teruya-Fel, D Perumal, VM Klimek, A Spyridonid, RK Rampal, L Silverman, EP Reddy, E Papaemmanu, S Parekh, BD Greenbaum, CS Leslie, MG Kharas, EP Papapetrou
Cell Stem Cell, 2017-02-16;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract
Authors: BA Boswell, A Korol, JA West-Mays, LS Musil
Mol. Biol. Cell, 2017-02-16;0(0):.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway
Authors: T Chattopadh, RR Singh, S Gupta, A Surolia
Biofactors, 2017-02-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Development of a human cardiac organoid injury model reveals innate regenerative potential
Authors: HK Voges, RJ Mills, DA Elliott, RG Parton, ER Porrello, JE Hudson
Development, 2017-02-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair
Authors: M Tiburcy, JE Hudson, P Balfanz, S Schlick, T Meyer, ML Chang Liao, E Levent, F Raad, S Zeidler, E Wingender, J Riegler, M Wang, JD Gold, I Kehat, E Wettwer, U Ravens, P Dierickx, LW van Laake, MJ Goumans, S Khadjeh, K Toischer, G Hasenfuss, LA Couture, A Unger, WA Linke, T Araki, B Neel, G Keller, L Gepstein, JC Wu, WH Zimmermann
Circulation, 2017-02-06;135(19):1832-1847.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of ID Proteins in BMP4 Inhibition of Profibrotic Effects of TGF-?2 in Human TM Cells
Authors: AA Mody, RJ Wordinger, AF Clark
Invest. Ophthalmol. Vis. Sci, 2017-02-01;58(2):849-859.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
Authors: Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, L Huan, HS Tan, R Kanesvaran, H Yu, MH Tan
Sci Rep, 2017-01-25;7(0):41238.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Integrated RNA-seq and DNase-seq analyses identify phenotype-specific BMP4 signaling in breast cancer
Authors: M Ampuja, T Rantapero, A Rodriguez-, M Palmroth, EL Alarmo, M Nykter, A Kallioniem
BMC Genomics, 2017-01-11;18(1):68.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inï¿½Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts
Authors: S Kadota, L Pabon, H Reinecke, CE Murry
Stem Cell Reports, 2017-01-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Wnt/?-catenin promotes gastric fundus specification in mice and humans
Authors: KW McCracken, E Aihara, B Martin, CM Crawford, T Broda, J Treguier, X Zhang, JM Shannon, MH Montrose, JM Wells
Nature, 2017-01-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Comparison between pediatric and adult adipose mesenchymal stromal cells
Authors: Olivier Abbo
Cytotherapy, 2016-12-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication
PLoS ONE, 2016-12-15;11(12):e0168334.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Five colour variants of bright luminescent protein for real-time multicolour bioimaging
Nat Commun, 2016-12-14;7(0):13718.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Binding of the Bone Morphogenetic Protein Antagonist Gremlin to Kidney Heparan Sulfate: Such Binding is not Essential for BMP Antagonism
Authors: Arnold Junior Tatsinkam
Int. J. Biochem. Cell Biol, 2016-12-12;0(0):.
Applications: Bioassay

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker
Nat. Biotechnol, 2016-12-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
Nat Commun, 2016-12-09;7(0):13602.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bovine ovarian stem cells differentiate into germ cells and oocyte-like structures after culture in vitro
Authors: G B de Souza
Reprod. Domest. Anim, 2016-12-07;0(0):.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction
Authors: Irene De Almeida
Dev. Biol, 2016-12-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells
Nat Protoc, 2016-12-01;12(1):15-31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MxA Is a Novel Regulator of Endosome-Associated Transcriptional Signaling by Bone Morphogenetic Proteins 4 and 9 (BMP4 and BMP9)
PLoS ONE, 2016-11-22;11(11):e0166382.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Capturing the biology of disease severity in a PSC-based model of familial dysautonomia
Authors: N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer
Nat. Med., 2016-11-14;22(12):1421-1427.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Yes-Associated Protein Inhibits Transcription of Myocardin and Attenuates Differentiation of Vascular Smooth Muscle Cell from Cardiovascular Progenitor Cell Lineage
Stem Cells, 2016-09-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells
EMBO Mol Med, 2016-09-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway
Cell Biosci, 2016-08-30;6(1):50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
Stem Cell Reports, 2016-08-25;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling
Stem Cell Res Ther, 2016-08-17;7(1):115.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells
Sci Rep, 2016-08-10;6(0):31063.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ROCK inhibitor primes human induced pluripotent stem cells to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation
Stem Cell Res, 2016-08-04;17(2):222-227.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients
Elife, 2016-07-26;5(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves
EBioMedicine, 2016-07-01;10(0):282-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease
Authors: Mariko Horii
Proc Natl Acad Sci USA, 2016-06-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prkci is required for a non-autonomous signal that coordinates cell polarity during cavitation.
Authors: In Kyoung Mah, Mah I, Soloff R, Izuhara A, Lakeland D, Mariani F
Dev Biol, 2016-06-14;416(1):82-97.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2.
Authors: Christine Kestens, Peter D Siersema, G Johan A Offerhaus, Jantine W P M Van Baal
PLoS ONE, 2016-05-18;0(0):1932-6203.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Medial HOXA genes demarcate haematopoietic stem cell fate during human development
Nat Cell Biol, 2016-05-16;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Coupling switch of P2Y-IP3 receptors mediates differential Ca(2+) signaling in human embryonic stem cells and derived cardiovascular progenitor cells
Authors: Huang-Tian Yang
Purinergic Signal., 2016-04-20;12(3):465-78.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The involvement of protein kinase C-? in isoflurane induced preconditioning of human embryonic stem cell--derived Nkx2.5(+) cardiac progenitor cells
Authors: IA Song, AY Oh, JH Kim, YM Choi, YT Jeon, JH Ryu, JW Hwang
BMC Anesthesiol, 2016-02-20;16(0):13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes
Stem Cells Transl Med, 2016-01-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer.
Authors: Hermanson D, Bendzick L, Pribyl L, McCullar V, Vogel R, Miller J, Geller M, Kaufman D
Stem Cells, 2015-12-06;34(1):93-101.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Automated image analysis with the potential for process quality control applications in stem cell maintenance and differentiation
Authors: Robert Thomas
Biotechnol. Prog., 2015-11-28;32(1):215-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

GSK3beta inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.
Authors: Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito M, Toyoda M, Umezawa A, Hara T
Exp Hematol, 2015-10-23;44(1):68-74.e10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells.
Authors: Kim J, Kurie J, Ahn Y
Mol Cancer, 2015-09-22;14(1):173.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling.
Authors: Ray P, Chapman S
PLoS ONE, 2015-08-03;10(8):e0134702.
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines.
Authors: Muller P, Doliva R, Busch M, Philippeit C, Stephan H, Dunker N
PLoS ONE, 2015-07-14;10(7):e0131467.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts.
Authors: Gerbin K, Yang X, Murry C, Coulombe K
PLoS ONE, 2015-07-10;10(7):e0131446.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Alternative Routes to Induce Naive Pluripotency in Human Embryonic Stem Cells.
Authors: Duggal G, Warrier S, Ghimire S, Broekaert D, Van der Jeught M, Lierman S, Deroo T, Peelman L, Van Soom A, Cornelissen R, Menten B, Mestdagh P, Vandesompele J, Roost M, Slieker R, Heijmans B, Deforce D, De Sutter P, de Sousa Lopes S, Heindryckx B
Stem Cells, 2015-06-24;33(9):2686-98.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor beta (TGFbeta)-mediated Germ Layer Induction in Xenopus Embryos.
Authors: Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, Fu Y, Ma X, Chen Y, Zhang M, Tao Q, Wu W
J Biol Chem, 2015-05-26;290(28):17239-49.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of articular chondrocytes from human pluripotent stem cells.
Authors: Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G
Nat Biotechnol, 2015-05-11;33(6):638-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology.
Authors: Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, Ricci-Vitiani L, D'Alessandris Q, Morgante L, Giannetti S, Larocca L, Todaro M, Benfante A, Colorito M, Stassi G, De Maria R, Rowlinson S, Stancato L
PLoS ONE, 2015-04-28;10(4):e0125697.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure.
Authors: Yang Y, Adachi K, Sheridan M, Alexenko A, Schust D, Schulz L, Ezashi T, Roberts R
Proc Natl Acad Sci U S A, 2015-04-13;112(18):E2337-46.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells.
Authors: Tadeu A, Lin S, Hou L, Chung L, Zhong M, Zhao H, Horsley V
PLoS ONE, 2015-04-07;10(4):e0122493.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Histone Chaperone HIRA in Regulation of Transcription Factor RUNX1.
Authors: Majumder A, Syed K, Joseph S, Scambler P, Dutta D
J Biol Chem, 2015-04-06;290(21):13053-63.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Reversible lineage-specific priming of human embryonic stem cells can be exploited to optimize the yield of differentiated cells.
Authors: Lee J, Graham M, Collins T, Lee J, Hong S, McNicol A, Shapovalova Z, Bhatia M
Stem Cells, 2015-04-01;33(4):1142-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells.
Authors: Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, Talasila A, Sinha S
Development, 2015-03-26;142(8):1528-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile.
Authors: Sugawa F, Arauzo-Bravo M, Yoon J, Kim K, Aramaki S, Wu G, Stehling M, Psathaki O, Hubner K, Scholer H
EMBO J, 2015-03-06;34(8):1009-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
Authors: Kim M, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J
PLoS ONE, 2015-02-23;10(2):e0118670.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcription factor binding dynamics during human ES cell differentiation.
Authors: Tsankov, Alexande, Gu, Hongcang, Akopian, Veronika, Ziller, Michael, Donaghey, Julie, Amit, Ido, Gnirke, Andreas, Meissner, Alexande
Nature, 2015-02-19;518(7539):344-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
Authors: Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, Nolan D, Elemento O, Wood B, Adair J, Rafii S, Kiem H
J Clin Invest, 2015-02-09;125(3):1243-54.
Species: Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system.
Authors: Song B, Fan Y, He W, Zhu D, Niu X, Wang D, Ou Z, Luo M, Sun X
Stem Cells Dev, 2015-02-05;24(9):1053-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
Nat Protoc, 2015-02-05;10(3):413-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.
Authors: Wong, Amy P, Chin, Stephani, Xia, Sunny, Garner, Jodi, Bear, Christin, Rossant, Janet
Nat Protoc, 2015-02-05;10(3):363-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face.
Authors: Hu D, Young N, Li X, Xu Y, Hallgrimsson B, Marcucio R
Development, 2015-02-01;142(3):567-74.
Species: Chicken
Sample Types: Whole Organism
Applications: In Vivo

Bone morphogenetic proteins are mediators of luteolysis in the human corpus luteum.
Authors: Nio-Kobayashi J, Trendell J, Giakoumelou S, Boswell L, Nicol L, Kudo M, Sakuragi N, Iwanaga T, Duncan W
Endocrinology, 2015-01-30;156(4):1494-503.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Constitutive activation of myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion.
Authors: Wong S, Ulrich T, Deleyrolle L, MacKay J, Lin J, Martuscello R, Jundi M, Reynolds B, Kumar S
Cancer Res, 2015-01-29;75(6):1113-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oligodendroglial maturation is dependent on intracellular protein shuttling.
Authors: Gottle P, Sabo J, Heinen A, Venables G, Torres K, Tzekova N, Parras C, Kremer D, Hartung H, Cate H, Kury P
J Neurosci, 2015-01-21;35(3):906-19.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency.
Authors: Malhotra, Rajeev, Burke, Megan F, Martyn, Trejeeve, Shakartzi, Hannah R, Thayer, Timothy, O'Rourke, Caitlin, Li, Pingchen, Derwall, Matthias, Spagnolli, Ester, Kolodziej, Starsha, Hoeft, Konrad, Mayeur, Claire, Jiramongkolchai, Pawina, Kumar, Ravindra, Buys, Emmanuel, Yu, Paul B, Bloch, Kenneth, Bloch, Donald B
PLoS ONE, 2015-01-20;10(1):e0117098.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Increased culture density is linked to decelerated proliferation, prolonged G1 phase, and enhanced propensity for differentiation of self-renewing human pluripotent stem cells.
Authors: Wu J, Fan Y, Tzanakakis E
Stem Cells Dev, 2014-12-22;24(7):892-903.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes.
Authors: Maury Y, Come J, Piskorowski R, Salah-Mohellibi N, Chevaleyre V, Peschanski M, Martinat C, Nedelec S
Nat Biotechnol, 2014-11-10;33(1):89-96.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies.
Authors: Dominguez, Antonia, Chiang, H Rosari, Sukhwani, Meena, Orwig, Kyle E, Reijo Pera, Renee A
Sci Rep, 2014-09-22;4(0):6432.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs.
Authors: Wile B, Ban K, Yoon Y, Bao G
Nat Protoc, 2014-09-18;9(10):2411-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Characterization of stem-like cells in mucoepidermoid tracheal paediatric tumor.
Authors: Lim M, Ooi B, Jungebluth P, Sjoqvist S, Hultman I, Lemon G, Gustafsson Y, Asmundsson J, Baiguera S, Douagi I, Gilevich I, Popova A, Haag J, Rodriguez A, Lim J, Lieden A, Nordenskjold M, Alici E, Baker D, Unger C, Luedde T, Vassiliev I, Inzunza J, Ahrlund-Richter L, Macchiarini P
PLoS ONE, 2014-09-17;9(9):e107712.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity.
Authors: Cao Y, Slaney C, Bidwell B, Parker B, Johnstone C, Rautela J, Eckhardt B, Anderson R
Cancer Res, 2014-09-15;74(18):5091-102.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells.
Authors: Lee, Rimi, Kim, Il-Sun, Han, Nalae, Yun, Seokhwan, Park, Kook In, Yoo, Kyung-Hw
Sci Rep, 2014-09-10;4(0):6319.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.
Authors: Shelton M, Metz J, Liu J, Carpenedo R, Demers S, Stanford W, Skerjanc I
Stem Cell Reports, 2014-08-07;3(3):516-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome.
Authors: Kobayashi, Junko, Yoshida, Masashi, Tarui, Suguru, Hirata, Masataka, Nagai, Yusuke, Kasahara, Shingo, Naruse, Keiji, Ito, Hiroshi, Sano, Shunji, Oh, Hidemasa
PLoS ONE, 2014-07-22;9(7):e102796.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression.
Authors: Josowitz, Rebecca, Lu, Jia, Falce, Christin, D'Souza, Sunita L, Wu, Meng, Cohen, Ninette, Dubois, Nicole C, Zhao, Yong, Sobie, Eric A, Fishman, Glenn I, Gelb, Bruce D
PLoS ONE, 2014-07-10;9(7):e101316.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
Authors: Dambrot C, Braam S, Tertoolen L, Birket M, Atsma D, Mummery C
J Cell Mol Med, 2014-07-01;18(8):1509-18.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice.
Authors: Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue H
Stem Cell Reports, 2014-06-26;3(2):242-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells.
Authors: Ao, Ying, Mich-Basso, Jocelyn, Lin, Bo, Yang, Lei
PLoS ONE, 2014-06-20;9(6):e100417.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs.
Authors: Park, Chul-Yon, Kim, Jungeun, Kweon, Jiyeon, Son, Jeong Sa, Lee, Jae Souk, Yoo, Jeong-Eu, Cho, Sung-Rae, Kim, Jong-Hoo, Kim, Jin-Soo, Kim, Dong-Woo
Proc Natl Acad Sci U S A, 2014-06-09;111(25):9253-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling.
Authors: Kim W, Zhu Y, Deng Q, Chin C, He C, Grieco A, Dravid G, Parekh C, Hollis R, Lane T, Bouhassira E, Kohn D, Crooks G
Stem Cells, 2014-06-01;32(6):1503-14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion.
Authors: Cabrera-Sharp V, Read J, Richardson S, Kowalski A, Antczak D, Cartwright J, Mukherjee A, de Mestre A
Endocrinology, 2014-05-21;155(8):3054-64.
Species: Equine
Sample Types: Whole Cells
Applications: Bioassay

A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear.
Authors: Mann Z, Thiede B, Chang W, Shin J, May-Simera H, Lovett M, Corwin J, Kelley M
Nat Commun, 2014-05-20;5(0):3839.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Broad T-cell receptor repertoire in T-lymphocytes derived from human induced pluripotent stem cells.
Authors: Chang C, Lai Y, Lamb L, Townes T
PLoS ONE, 2014-05-14;9(5):e97335.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling.
Authors: Jakobsen R, Ostrup E, Zhang X, Mikkelsen T, Brinchmann J
PLoS ONE, 2014-05-09;9(5):e96615.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Alk2 regulates early chondrogenic fate in fibrodysplasia ossificans progressiva heterotopic endochondral ossification.
Authors: Culbert A, Chakkalakal S, Theosmy E, Brennan T, Kaplan F, Shore E
Stem Cells, 2014-05-01;32(5):1289-300.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm.
Authors: Takahashi K, Tanabe K, Ohnuki M, Narita M, Sasaki A, Yamamoto M, Nakamura M, Sutou K, Osafune K, Yamanaka S
Nat Commun, 2014-04-24;5(0):3678.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo.
Authors: Luo J, Weaver M, Cao B, Dennis J, Van Biber B, Laflamme M, Allen M
Stem Cells Transl Med, 2014-04-15;3(6):734-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Enzyme-free passage of human pluripotent stem cells by controlling divalent cations.
Authors: Ohnuma, Kiyoshi, Fujiki, Ayaka, Yanagihara, Kana, Tachikawa, Saoko, Hayashi, Yohei, Ito, Yuzuru, Onuma, Yasuko, Chan, Techuan, Michiue, Tatsuo, Furue, Miho K, Asashima, Makoto
Sci Rep, 2014-04-11;4(0):4646.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.
Authors: Olsen O, Wader K, Misund K, Vatsveen T, Ro T, Mylin A, Turesson I, Stordal B, Moen S, Standal T, Waage A, Sundan A, Holien T
Blood Cancer J, 2014-03-21;4(0):e196.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.
Authors: Watanabe, Hitoshi, Takayama, Kazuo, Inamura, Mitsuru, Tachibana, Masashi, Mimura, Natsumi, Katayama, Kazufumi, Tashiro, Katsuhis, Nagamoto, Yasuhito, Sakurai, Fuminori, Kawabata, Kenji, Furue, Miho Kus, Mizuguchi, Hiroyuki
PLoS ONE, 2014-03-20;9(3):e90791.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Functional assessment of hematopoietic niche cells derived from human embryonic stem cells.
Authors: Ferrell, Patrick, Hexum, Melinda, Kopher, Ross A, Lepley, Michael, Gussiaas, Amanda, Kaufman, Dan S
Stem Cells Dev, 2014-03-11;23(12):1355-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inner ear hair cell-like cells from human embryonic stem cells.
Authors: Ronaghi, Mohammad, Nasr, Marjan, Ealy, Megan, Durruthy-Durruthy, Robert, Waldhaus, Joerg, Diaz, Giovanni, Joubert, Lydia-Ma, Oshima, Kazuo, Heller, Stefan
Stem Cells Dev, 2014-03-10;23(11):1275-84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.
Authors: Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, Apuzzo T, Sperduti I, Volpe S, Cocorullo G, Gulotta G, Dieli F, De Maria R, Stassi G
Cell Stem Cell, 2014-03-06;14(3):342-56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.
Authors: Lorda-Diez C, Montero J, Choe S, Garcia-Porrero J, Hurle J
J Bone Miner Res, 2014-03-01;29(3):735-48.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury.
Authors: Yamada, Sachiko, Nakamura, Jin, Asada, Misako, Takase, Masayuki, Matsusaka, Taiji, Iguchi, Taku, Yamada, Ryo, Tanaka, Mari, Higashi, Atsuko Y, Okuda, Tomohiko, Asada, Nariaki, Fukatsu, Atsushi, Kawachi, Hiroshi, Graf, Daniel, Muso, Eri, Kita, Toru, Kimura, Takeshi, Pastan, Ira, Economides, Aris N, Yanagita, Motoko
PLoS ONE, 2014-02-25;9(2):e89135.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The role of Hath6, a newly identified shear-stress-responsive transcription factor, in endothelial cell differentiation and function.
Authors: Fang F, Wasserman S, Torres-Vazquez J, Weinstein B, Cao F, Li Z, Wilson K, Yue W, Wu J, Xie X, Pei X
J Cell Sci, 2014-01-24;127(0):1428-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells.
Authors: Lin, I-Ying, Chiu, Feng-Lan, Yeang, Chen-Hsi, Chen, Hsin-Fu, Chuang, Ching-Yu, Yang, Shii-Yi, Hou, Pei-Shan, Sintupisut, Nardnisa, Ho, Hong-Ner, Kuo, Hung-Chi, Lin, Kuo-I
Stem Cell Reports, 2014-01-23;2(2):189-204.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant.
Authors: Takebe, Takanori, Zhang, Ran-Ran, Koike, Hiroyuki, Kimura, Masaki, Yoshizawa, Emi, Enomura, Masahiro, Koike, Naoto, Sekine, Keisuke, Taniguchi, Hideki
Nat Protoc, 2014-01-23;9(2):396-409.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells.
Authors: Yang, Ruifeng, Zheng, Ying, Burrows, Michelle, Liu, Shujing, Wei, Zhi, Nace, Arben, Guo, Wei, Kumar, Suresh, Cotsarelis, George, Xu, Xiaowei
Nat Commun, 2014-01-01;5(0):3071.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells.
Authors: Kohler, Erin E, Wary, Kishore, Li, Fei, Chatterjee, Ishita, Urao, Norifumi, Toth, Peter T, Ushio-Fukai, Masuko, Rehman, Jalees, Park, Changwon, Malik, Asrar B
PLoS ONE, 2013-12-30;8(12):e85549.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
Authors: Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J
J Am Soc Nephrol, 2013-12-19;25(6):1211-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes.
Authors: Xue, Ruidan, Wan, Yun, Zhang, Shuo, Zhang, Qiongyue, Ye, Hongying, Li, Yiming
Am J Physiol Endocrinol Metab, 2013-12-17;306(4):E363-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.
Authors: Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R
Cell Stem Cell, 2013-12-12;14(1):53-67.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies.
Authors: Goyal, Akshi, Chavez, Shawn L, Reijo Pera, Renee A
PLoS ONE, 2013-12-12;8(12):e82838.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa.
Authors: Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J
J Invest Dermatol, 2013-12-06;134(5):1246-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
Authors: Huang, Sarah X, Islam, Mohammad, O'Neill, John, Hu, Zheng, Yang, Yong-Gua, Chen, Ya-Wen, Mumau, Melanie, Green, Michael, Vunjak-Novakovic, Gordana, Bhattacharya, Jahar, Snoeck, Hans-Wil
Nat Biotechnol, 2013-12-01;32(1):84-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision.
Authors: Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue M, Mizuguchi H
Development, 2013-11-27;141(1):91-100.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells.
Authors: Srikanth, Maya, Kim, Juno, Das, Sunit, Kessler, John A
Mol Cancer Res, 2013-11-22;12(2):283-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.
Authors: Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S
Elife, 2013-11-19;2(0):e00940.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice.
Authors: Zhang Y, Liu J, Tian X, Wong W, Chen Y, Wang L, Luo J, Cheang W, Lau C, Kwan K, Wang N, Yao X, Huang Y
Arterioscler Thromb Vasc Biol, 2013-11-07;34(1):152-9.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium.
Authors: Turnbull I, Karakikes I, Serrao G, Backeris P, Lee J, Xie C, Senyei G, Gordon R, Li R, Akar F, Hajjar R, Hulot J, Costa K
FASEB J, 2013-10-30;28(2):644-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-beta1/SMAD5 signaling module.
Authors: Jiang D, Aguiar R
Blood, 2013-10-17;123(1):86-93.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression.
Authors: Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, Ffrench M, Salesse S, Nicolini F, Maguer-Satta V
Blood, 2013-10-07;122(23):3767-77.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
Authors: Doulatov S, Vo L, Chou S, Kim P, Arora N, Li H, Hadland B, Bernstein I, Collins J, Zon L, Daley G
Cell Stem Cell, 2013-10-03;13(4):459-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes.
Authors: Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H
Stem Cell Reports, 2013-10-03;1(4):322-35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease.
Authors: Fujiwara, Tohru, Ikeda, Takashi, Nagasaka, Yuki, Okitsu, Yoko, Katsuoka, Yuna, Fukuhara, Noriko, Onishi, Yasushi, Ishizawa, Kenichi, Ichinohasama, Ryo, Tomosugi, Naohisa, Harigae, Hideo
PLoS ONE, 2013-09-27;8(9):e75568.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation.
Authors: Talavera-Adame, Dodanim, Gupta, Ankur, Kurtovic, Silvia, Chaiboonma, Kira L, Arumugaswami, Vaithili, Dafoe, Donald C
Stem Cells Dev, 2013-09-24;22(24):3252-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NLRP7 affects trophoblast lineage differentiation, binds to overexpressed YY1 and alters CpG methylation.
Authors: Mahadevan, Sangeeth, Wen, Shu, Wan, Ying-Woo, Peng, Hsiu-Hue, Otta, Subhendu, Liu, Zhandong, Iacovino, Michelin, Mahen, Elisabet, Kyba, Michael, Sadikovic, Bekim, Van den Veyver, Ignatia
Hum Mol Genet, 2013-09-18;23(3):706-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays.
Authors: Navarrete E, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge P, Patlolla B, Lee A, Wu H, Beygui R, Wu S, Robbins R, Bers D, Wu J
Circulation, 2013-09-10;128(11):S3-13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors.
Authors: Tsuchida, R, Osawa, T, Wang, F, Nishii, R, Das, B, Tsuchida, S, Muramatsu, M, Takahashi, T, Inoue, T, Wada, Y, Minami, T, Yuasa, Y, Shibuya, M
Oncogene, 2013-09-09;33(29):3803-11.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis.
Authors: Morishima, Tatsuya, Watanabe, Ken-ichi, Niwa, Akira, Hirai, Hideyo, Saida, Satoshi, Tanaka, Takayuki, Kato, Itaru, Umeda, Katsutsu, Hiramatsu, Hidefumi, Saito, Megumu K, Matsubara, Kousaku, Adachi, Souichi, Kobayashi, Masao, Nakahata, Tatsutos, Heike, Toshio
Haematologica, 2013-08-23;99(1):19-27.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential.
Authors: Duggal G, Heindryckx B, Warrier S, O'Leary T, Van der Jeught M, Lierman S, Vossaert L, Deroo T, Deforce D, Chuva de Sousa Lopes S, De Sutter P
Stem Cells Dev, 2013-08-14;22(23):3141-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.
Authors: Goldman O, Han S, Sourisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton D, Bissig K, Kalir T, Jacobs A, Evans T, Evans M, Gouon-Evans V
Cell Stem Cell, 2013-06-06;12(6):748-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A human Dravet syndrome model from patient induced pluripotent stem cells.
Authors: Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori M, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S
Mol Brain, 2013-05-02;6(0):19.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue.
Authors: Deschaseaux F, Gaillard J, Langonne A, Chauveau C, Naji A, Bouacida A, Rosset P, Heymann D, De Pinieux G, Rouas-Freiss N, Sensebe L
FASEB J, 2013-04-16;27(8):2977-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal.
Authors: Wang Y, Xu Z, Jiang J, Xu C, Kang J, Xiao L, Wu M, Xiong J, Guo X, Liu H
Dev Cell, 2013-03-28;25(1):69-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.
Authors: Glister C, Satchell L, Bathgate R, Wade J, Dai Y, Ivell R, Anand-Ivell R, Rodgers R, Knight P
Proc Natl Acad Sci U S A, 2013-03-25;110(15):E1426-35.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
Authors: Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel C, Hoing S, Moritz S, Parga J, Wagner L, Bruder J, Wu G, Schmid B, Ropke A, Klingauf J, Schwamborn J, Gasser T, Scholer H, Sterneckert J
PLoS ONE, 2013-03-22;8(3):e59252.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Authors: Liang, Ping, Lan, Feng, Lee, Andrew S, Gong, Tingyu, Sanchez-Freire, Veronica, Wang, Yongming, Diecke, Sebastia, Sallam, Karim, Knowles, Joshua W, Wang, Paul J, Nguyen, Patricia, Bers, Donald M, Robbins, Robert C, Wu, Joseph C
Circulation, 2013-03-21;127(16):1677-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of small molecule activators of BMP signaling.
Authors: Vrijens K, Lin W, Cui J, Farmer D, Low J, Pronier E, Zeng F, Shelat A, Guy K, Taylor M, Chen T, Roussel M
PLoS ONE, 2013-03-19;8(3):e59045.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

BMP4 is a peripherally-derived factor for motor neurons and attenuates glutamate-induced excitotoxicity in vitro.
Authors: Chou H, Lai D, Huang C, McLennan I, Wang H, Wang P
PLoS ONE, 2013-03-05;8(3):e58441.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential.
Authors: Gu L, Johno H, Nakajima S, Kato H, Takahashi S, Katoh R, Kitamura M
Lab Invest, 2013-02-25;93(4):450-61.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Generation of megakaryocytic progenitors from human embryonic stem cells in a feeder- and serum-free medium.
Authors: Pick M, Azzola L, Osborne E, Stanley E, Elefanty A
PLoS ONE, 2013-02-12;8(2):e55530.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Production of hepatocyte-like cells from human pluripotent stem cells.
Authors: Hannan, Nicholas, Segeritz, Charis-P, Touboul, Thomas, Vallier, Ludovic
Nat Protoc, 2013-01-01;8(2):430-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.
Authors: White M, Rufaihah A, Liu L, Ghebremariam Y, Ivey K, Cooke J, Srivastava D
Stem Cells, 2013-01-01;31(1):92-103.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems.
Authors: Aad, Pauline, Echternkamp, Sherrill, Sypherd, David D, Schreiber, Nicole B, Spicer, Leon J
Biol Reprod, 2012-10-04;87(4):79.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma.
Authors: Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J
PLoS ONE, 2012-10-01;7(10):e46117.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs).
Authors: Wu, Qifang, Sun, Chia Chi, Lin, Herbert, Babitt, Jodie L
PLoS ONE, 2012-09-27;7(9):e46307.
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.
Authors: Pereira P, Dobreva M, Maas E, Cornelis F, Moya I, Umans L, Verfaillie C, Camus A, de Sousa Lopes S, Huylebroeck D, Zwijsen A
Development, 2012-09-01;139(18):3343-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-beta-induced apoptosis of B-cell lymphoma Ramos cells through reduction of MS4A1/CD20.
Authors: Kawabata K, Ehata S, Komuro A, Takeuchi K, Miyazono K
Oncogene, 2012-06-04;32(16):2096-106.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion.
Authors: Kim M, Yoon S, Lee S
PLoS ONE, 2012-04-13;7(4):e35100.
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay

Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium.
Authors: Yao Y, Jumabay M, Ly A, Radparvar M, Wang AH, Abdmaulen R, Bostrom KI
Blood, 2012-04-03;119(21):5037-47.
Species: Human
Sample Types: Cell Lysates
Applications: Bioassay

The endothelial cell line bEnd.3 maintains human pluripotent stem cells.
Authors: Joubin, Katherin, Richardson, Amelia, Novoa, Natalia, Tu, Edmund, Tomishima, Mark J
Stem Cells Dev, 2012-02-21;21(12):2312-21.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Authors: Cheung C, Bernardo AS, Trotter MW
Nat. Biotechnol., 2012-01-15;30(2):165-73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
Gene Ther, 2011-11-10;19(10):1035-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.
Authors: Huse K, Bakkebo M, Oksvold MP, Forfang L, Hilden VI, Stokke T, Smeland EB, Myklebust JH
Eur. J. Immunol., 2011-10-18;41(11):3135-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells.
Authors: Wong RC, Pollan S, Fong H, Ibrahim A, Smith EL, Ho M, Laslett AL, Donovan PJ
Stem Cells, 2011-10-01;29(10):1517-27.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma.
Authors: Maegdefrau U, Arndt S, Kivorski G, Hellerbrand C, Bosserhoff AK
Lab. Invest., 2011-08-22;91(11):1615-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.
Authors: Niwa A, Heike T, Umeda K
PLoS ONE, 2011-07-27;6(7):e22261.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-kappaB activation and apoptosis in P19 cells.
Authors: Rochira JA, Matluk NN, Adams TL, Karaczyn AA, Oxburgh L, Hess ST, Verdi JM
PLoS ONE, 2011-07-18;6(7):e20659.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
J. Biol. Chem., 2011-07-07;286(34):30034-46.
Species: Human, Mouse
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4.
Authors: Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A
J. Biol. Chem., 2011-06-13;286(32):28097-110.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells.
Authors: Geens M, Sermon KD
J. Assist. Reprod. Genet., 2011-02-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals.
Authors: Zhang Q, Jiang J, Han P, Yuan Q, Zhang J, Zhang X, Xu Y, Cao H, Meng Q, Chen L, Tian T, Wang X, Li P, Hescheler J, Ji G, Ma Y
Cell Res., 2010-11-23;21(4):579-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A defined glycosaminoglycan-binding substratum for human pluripotent stem cells.
Authors: Klim JR, Li L, Wrighton PJ
Nat. Methods, 2010-11-14;7(12):989-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).
Authors: Tolar J, Park I, Xia L, Lees C, Peacock B, Webber B, McElmurry R, Eide C, Orchard P, Kyba M, Osborn M, Lund T, Wagner J, Daley G, Blazar B
Blood, 2010-10-29;117(3):839-47.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
PLoS ONE, 2010-08-11;5(8):e12101.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain.
Authors: Martino MM, Hubbell JA
FASEB J., 2010-07-29;24(12):4711-21.
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway.
Authors: Stewart A, Guan H, Yang K
J. Cell. Physiol., 2010-06-01;223(3):658-66.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state.
Authors: Lanner F, Lee KL, Sohl M, Holmborn K, Yang H, Wilbertz J, Poellinger L, Rossant J, Farnebo F
Stem Cells, 2010-02-01;28(2):191-200.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis.
Authors: Rai D, Kim SW, McKeller MR
Proc. Natl. Acad. Sci. U.S.A., 2010-02-01;107(7):3111-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.
Authors: Chng Z, Teo A, Pedersen RA, Vallier L
Cell Stem Cell, 2010-01-08;6(1):59-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes.
Authors: Grcevic D, Kusec R, Kovacic N, Lukic A, Lukic IK, Ivcevic S, Nemet D, Seiwerth RS, Ostojic SK, Croucher PI, Marusic A
Leuk. Res., 2009-11-18;34(6):742-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells.
Authors: Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ
Biol. Reprod., 2009-06-24;81(5):833-41.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Scaffold-free human cardiac tissue patch created from embryonic stem cells.
Authors: Stevens KR, Pabon L, Muskheli V
Tissue Eng Part A, 2009-06-01;15(6):1211-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases.
Authors: Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW
Proc. Natl. Acad. Sci. U.S.A., 2009-05-29;106(24):9826-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury.
Authors: Sellers DL, Maris DO, Horner PJ
J. Neurosci., 2009-05-20;29(20):6722-33.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.
Authors: Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL
Blood, 2009-05-04;114(1):181-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum.
Authors: Herrera B, Inman GJ
BMC Cell Biol., 2009-03-19;10(0):20.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Signaling hierarchy regulating human endothelial cell development.
Authors: Kelly MA, Hirschi KK
Arterioscler. Thromb. Vasc. Biol., 2009-02-12;29(5):718-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells.
Authors: Bernardo AS, Cho CH, Mason S, Docherty HM, Pedersen RA, Vallier L, Docherty K
Stem Cells, 2009-02-01;27(2):341-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2.
Authors: Yao Y, Shao ES, Jumabay M, Shahbazian A, Ji S, Bostrom KI
Arterioscler. Thromb. Vasc. Biol., 2008-10-23;28(12):2266-74.
Species: Bovine, Human
Sample Types: Whole Cells
Applications: Bioassay

Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells.
Authors: Saeki K, Yogiashi Y, Nakahara M, Nakamura N, Matsuyama S, Koyanagi A, Yagita H, Koyanagi M, Kondo Y, Yuo A
J. Cell. Physiol., 2008-10-01;217(1):261-80.
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Essential role of BMPs in FGF-induced secondary lens fiber differentiation.
Authors: Boswell BA, Overbeek PA, Musil LS
Dev. Biol., 2008-09-18;324(2):202-12.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses.
Authors: Levine AJ, Levine ZJ, Brivanlou AH
Dev. Biol., 2008-09-18;325(1):43-8.
Species: Xenopus
Sample Types: Whole Cells
Applications: Bioassay

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
Authors: Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR
Nature, 2008-08-21;454(7207):1000-4.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling.
Authors: Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V
Blood, 2008-07-29;112(8):3154-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells.
Authors: Wu Z, Zhang W, Chen G, Cheng L, Liao J, Jia N, Gao Y, Dai H, Yuan J, Cheng L, Xiao L
J. Biol. Chem., 2008-07-02;283(36):24991-5002.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
Authors: Kane R, Godson C, O'Brien C
Mol. Vis., 2008-06-20;14(0):1138-48.
Species: Human
Sample Types: Cell Lysates, Whole Cells
Applications: Binding Assay, Bioassay

High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Authors: Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
Cell Stem Cell, 2008-06-05;2(6):602-12.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Authors: Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM
Nature, 2008-04-23;453(7194):524-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins.
Authors: Chen G, Ye Z, Yu X, Zou J, Mali P, Brodsky RA, Cheng L
Cell Stem Cell, 2008-04-10;2(4):345-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells.
Authors: Boswell BA, Lein PJ, Musil LS
Mol. Biol. Cell, 2008-04-09;19(6):2631-41.
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture.
Authors: Sun Y, Pollard S, Conti L, Toselli M, Biella G, Parkin G, Willatt L, Falk A, Cattaneo E, Smith A
Mol. Cell. Neurosci., 2008-03-18;38(2):245-58.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting of bone morphogenetic protein growth factor complexes to fibrillin.
Authors: Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY
J. Biol. Chem., 2008-03-13;283(20):13874-88.
Species: Human
Sample Types: Recombinant Protein
Applications: Binding Assay, Surface Plasmon Resonance

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.
Authors: Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L
Genes Dev., 2008-01-15;22(2):152-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.
Authors: Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW
J. Pathol., 2008-01-01;214(1):85-95.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus.
Authors: Anderson BC, Christiansen SP, McLoon LK
Invest. Ophthalmol. Vis. Sci., 2008-01-01;49(1):221-9.
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
Authors: Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S
Cell, 2007-11-30;131(5):861-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
Authors: Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H
Blood, 2007-11-27;111(4):1933-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells.
Authors: Zode GS, Clark AF, Wordinger RJ
Invest. Ophthalmol. Vis. Sci., 2007-11-01;48(11):5058-67.
Species: Human
Sample Types: N/A, Whole Cells
Applications: Bioassay, Western Blot

Predicting evolutionary patterns of mammalian teeth from development.
Authors: Kavanagh KD, Evans AR, Jernvall J
Nature, 2007-09-27;449(7161):427-32.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

A rapid and sensitive bioassay to measure bone morphogenetic protein activity.
Authors: Zilberberg L, ten Dijke P, Sakai L, Rifkin D
BMC Cell Biol, 2007-09-19;8(0):41.
Applications: Bioassay

Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions.
Authors: Fuller ML, DeChant AK, Rothstein B, Caprariello A, Wang R, Hall AK, Miller RH
Ann. Neurol., 2007-09-01;62(3):288-300.
Species: Rat
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification.
Authors: Stavridis MP, Lunn JS, Collins BJ, Storey KG
Development, 2007-08-01;134(16):2889-94.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

New cell lines from mouse epiblast share defining features with human embryonic stem cells.
Authors: Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD
Nature, 2007-06-27;448(7150):196-9.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.
Authors: Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T
Blood, 2007-05-31;110(6):2182-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway.
Authors: Knobloch J, Shaughnessy JD, Ruther U
FASEB J., 2007-02-05;21(7):1410-21.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
Authors: Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF
Stem Cells, 2007-02-01;25(2):490-9.
Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor.
Authors: Stabile H, Mitola S, Moroni E, Belleri M, Nicoli S, Coltrini D, Peri F, Pessi A, Orsatti L, Talamo F, Castronovo V, Waltregny D, Cotelli F, Ribatti D, Presta M
Blood, 2006-10-31;109(5):1834-40.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.
Authors: Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y
Development, 2006-10-11;133(22):4463-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm.
Authors: Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM
Development, 2006-08-30;133(19):3787-96.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Multipotent adult progenitor cells from swine bone marrow.
Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
Stem Cells, 2006-08-24;24(11):2355-66.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression.
Authors: Bonafede A, Kohler T, Rodriguez-Niedenfuhr M, Brand-Saberi B
Dev. Biol., 2006-06-15;299(2):330-44.
Species: Chicken
Sample Types: In Vivo
Applications: In Vivo

Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4.
Authors: Kiyono M, Shibuya M
Oncogene, 2006-05-29;25(54):7131-7.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells.
Authors: Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K
Stem Cells, 2006-05-25;24(9):2014-22.
Species: Primate - Callitrix jacchus (Common Marmoset)
Sample Types: Whole Cells
Applications: Bioassay

Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells.
Authors: Spicer LJ, Aad PY, Allen D, Mazerbourg S, Hsueh AJ
J. Endocrinol., 2006-05-01;189(2):329-39.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct.
Authors: Maeshima A, Vaughn DA, Choi Y, Nigam SK
Dev. Biol., 2006-04-27;295(2):473-85.
Species: Rat
Sample Types: Whole Tissue
Applications: Bioassay

Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions.
Authors: Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S
Proc. Natl. Acad. Sci. U.S.A., 2006-04-21;103(18):6907-12.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field.
Authors: Reversade B, De Robertis EM
Cell, 2005-12-16;123(6):1147-60.
Species: Xenopus
Sample Types: In Vivo
Applications: In Vivo

Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish.
Authors: Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A, Bally-Cuif L, Schilling TF
Development, 2005-08-01;132(16):3731-42.
Species: Xenopus
Sample Types: In Vivo
Applications: In Vivo

Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer.
Authors: Ng RK, Gurdon JB
Proc. Natl. Acad. Sci. U.S.A., 2005-01-31;102(6):1957-62.
Species: Xenopus
Sample Types: Whole Cells
Applications: Bioassay

Molecular basis of bone morphogenetic protein-4 inhibitory action on progesterone secretion by ovine granulosa cells.
Authors: Pierre A, Pisselet C, Dupont J, Mandon-Pepin B, Monniaux D, Monget P, Fabre S
J. Mol. Endocrinol., 2004-12-01;33(3):805-17.
Species: Ovine
Sample Types: Whole Cells
Applications: Bioassay

Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.
Authors: Blair DG, Plisov S, Vasiliev G, Perantoni AO, Athanasiou M, Wu JY, Oppenheim JJ
J. Immunol., 2004-11-15;173(10):5914-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Retinoic acid signalling specifies intermediate character in the developing telencephalon.
Authors: Marklund M, Sjodal M, Beehler BC, Jessell TM, Edlund T, Gunhaga L
Development, 2004-08-04;131(17):4323-32.
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation.
Authors: Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, Savitsky K, Rotman G
Gene, 2004-04-28;331(0):17-31.
Species: Human
Sample Types:
Applications: Bioassay

Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.
Authors: Binnerts ME, Wen X, Cante-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F
Biochem. Biophys. Res. Commun., 2004-03-05;315(2):272-80.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Blocked MAP kinase activity selectively enhances neurotrophic growth responses.
Authors: Althini S, Usoskin D, Kylberg A, Kaplan PL, Ebendal T
Mol. Cell. Neurosci., 2004-02-01;25(2):345-54.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development.
Authors: Wakamatsu Y, Endo Y, Osumi N, Weston JA
Dev. Dyn., 2004-01-01;229(1):74-86.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay

BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation.
Authors: Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C
Mol. Cell. Biol., 2003-08-01;23(16):5664-79.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2.
Authors: Viti J, Gulacsi A, Lillien L
J. Neurosci., 2003-07-02;23(13):5919-27.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Effect of recombinant human bone morphogenetic protein-4 with carriers in rat calvarial defects.
Authors: Ahn SH, Kim CS, Suk HJ, Lee YJ, Choi SH, Chai JK, Kim CK, Han SB, Cho KS
J. Periodontol., 2003-06-01;74(6):787-97.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

FGF8 acts as a right determinant during establishment of the left-right axis in the rabbit.
Authors: Fischer A, Viebahn C, Blum M
Curr. Biol., 2002-10-29;12(21):1807-16.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

FAQs

Can Recombinant Human BMP-4 Protein (Catalog # 314-BP or 314-BP/CF) be reconstituted in PBS or water?
- Recombinant Human BMP-4 (Catalog # 314-BP or 314-BP/CF) needs to be reconstituted to 50-200 μg/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl to ensure optimal recovery, stability, and activity. This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to go completely into solution. Stability testing has been evaluated on the protein with these reconstitution conditions; we can guarantee performance under these reconstitution conditions. When the protein is diluted with the cell culture media or buffers to the working concentration, the concentration of the acid should be buffered or negligible.

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